6CQ5

TBK1 in Complex with Sulfone Analog of Amlexanox

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002181	biological_process	cytoplasmic translation
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
A	0003676	molecular_function	nucleic acid binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0006606	biological_process	protein import into nucleus
A	0006954	biological_process	inflammatory response
A	0007249	biological_process	canonical NF-kappaB signal transduction
A	0009299	biological_process	mRNA transcription
A	0009615	biological_process	response to virus
A	0010468	biological_process	regulation of gene expression
A	0010508	biological_process	positive regulation of autophagy
A	0010629	biological_process	negative regulation of gene expression
A	0016236	biological_process	macroautophagy
A	0016239	biological_process	positive regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019222	biological_process	regulation of metabolic process
A	0019903	molecular_function	protein phosphatase binding
A	0023019	biological_process	signal transduction involved in regulation of gene expression
A	0031669	biological_process	cellular response to nutrient levels
A	0032008	biological_process	positive regulation of TOR signaling
A	0032479	biological_process	regulation of type I interferon production
A	0032480	biological_process	negative regulation of type I interferon production
A	0032481	biological_process	positive regulation of type I interferon production
A	0032727	biological_process	positive regulation of interferon-alpha production
A	0032728	biological_process	positive regulation of interferon-beta production
A	0034142	biological_process	toll-like receptor 4 signaling pathway
A	0038202	biological_process	TORC1 signaling
A	0038203	biological_process	TORC2 signaling
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0044565	biological_process	dendritic cell proliferation
A	0045087	biological_process	innate immune response
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0045948	biological_process	positive regulation of translational initiation
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051219	molecular_function	phosphoprotein binding
A	0051607	biological_process	defense response to virus
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0060340	biological_process	positive regulation of type I interferon-mediated signaling pathway
A	0061470	biological_process	T follicular helper cell differentiation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0098542	biological_process	defense response to other organism
A	0106310	molecular_function	protein serine kinase activity
A	0140374	biological_process	antiviral innate immune response
A	0140896	biological_process	cGAS/STING signaling pathway
A	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
A	1902554	cellular_component	serine/threonine protein kinase complex
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1904417	biological_process	positive regulation of xenophagy
A	1904515	biological_process	positive regulation of TORC2 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue F8S A 801

Chain	Residue
A	LEU15
A	ALA36
A	MET86
A	GLU87
A	PHE88
A	CYS89
A	PRO90
A	MET142
A	THR156

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........FAIK

Chain	Residue	Details
A	LEU15-LYS38

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Domain: {"description":"Ubiquitin-like"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23453971","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23453972","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30842653","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; by SETD4","evidences":[{"source":"PubMed","id":"37926288","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23453971","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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