6CP3

Monomer yeast ATP synthase (F1Fo) reconstituted in nanodisc with inhibitor of oligomycin bound.

Functional Information from GO Data

Chain	GOid	namespace	contents
6	0015986	biological_process	proton motive force-driven ATP synthesis
7	0005739	cellular_component	mitochondrion
7	0005743	cellular_component	mitochondrial inner membrane
7	0006754	biological_process	ATP biosynthetic process
7	0006811	biological_process	monoatomic ion transport
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0045259	cellular_component	proton-transporting ATP synthase complex
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	1902600	biological_process	proton transmembrane transport
8	0005739	cellular_component	mitochondrion
8	0005743	cellular_component	mitochondrial inner membrane
8	0006754	biological_process	ATP biosynthetic process
8	0006811	biological_process	monoatomic ion transport
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0031966	cellular_component	mitochondrial membrane
8	0045259	cellular_component	proton-transporting ATP synthase complex
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	1902600	biological_process	proton transmembrane transport
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016887	molecular_function	ATP hydrolysis activity
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042645	cellular_component	mitochondrial nucleoid
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016887	molecular_function	ATP hydrolysis activity
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042645	cellular_component	mitochondrial nucleoid
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016887	molecular_function	ATP hydrolysis activity
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042645	cellular_component	mitochondrial nucleoid
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016887	molecular_function	ATP hydrolysis activity
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0045259	cellular_component	proton-transporting ATP synthase complex
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005829	cellular_component	cytosol
K	0006811	biological_process	monoatomic ion transport
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016887	molecular_function	ATP hydrolysis activity
K	0031966	cellular_component	mitochondrial membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0042802	molecular_function	identical protein binding
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0006811	biological_process	monoatomic ion transport
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016887	molecular_function	ATP hydrolysis activity
L	0031966	cellular_component	mitochondrial membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0042802	molecular_function	identical protein binding
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005829	cellular_component	cytosol
M	0006811	biological_process	monoatomic ion transport
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016887	molecular_function	ATP hydrolysis activity
M	0031966	cellular_component	mitochondrial membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042802	molecular_function	identical protein binding
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005829	cellular_component	cytosol
N	0006811	biological_process	monoatomic ion transport
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016887	molecular_function	ATP hydrolysis activity
N	0031966	cellular_component	mitochondrial membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042802	molecular_function	identical protein binding
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005829	cellular_component	cytosol
O	0006811	biological_process	monoatomic ion transport
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016887	molecular_function	ATP hydrolysis activity
O	0031966	cellular_component	mitochondrial membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042802	molecular_function	identical protein binding
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0006811	biological_process	monoatomic ion transport
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016887	molecular_function	ATP hydrolysis activity
P	0031966	cellular_component	mitochondrial membrane
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0042802	molecular_function	identical protein binding
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0005829	cellular_component	cytosol
Q	0006811	biological_process	monoatomic ion transport
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0031966	cellular_component	mitochondrial membrane
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0042802	molecular_function	identical protein binding
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005758	cellular_component	mitochondrial intermembrane space
R	0005829	cellular_component	cytosol
R	0006811	biological_process	monoatomic ion transport
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0016887	molecular_function	ATP hydrolysis activity
R	0031966	cellular_component	mitochondrial membrane
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0042802	molecular_function	identical protein binding
R	0045259	cellular_component	proton-transporting ATP synthase complex
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005758	cellular_component	mitochondrial intermembrane space
S	0005829	cellular_component	cytosol
S	0006811	biological_process	monoatomic ion transport
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016887	molecular_function	ATP hydrolysis activity
S	0031966	cellular_component	mitochondrial membrane
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0042802	molecular_function	identical protein binding
S	0045259	cellular_component	proton-transporting ATP synthase complex
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005758	cellular_component	mitochondrial intermembrane space
T	0005829	cellular_component	cytosol
T	0006811	biological_process	monoatomic ion transport
T	0008289	molecular_function	lipid binding
T	0015078	molecular_function	proton transmembrane transporter activity
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0016887	molecular_function	ATP hydrolysis activity
T	0031966	cellular_component	mitochondrial membrane
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0042802	molecular_function	identical protein binding
T	0045259	cellular_component	proton-transporting ATP synthase complex
T	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
T	1902600	biological_process	proton transmembrane transport
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006754	biological_process	ATP biosynthetic process
U	0006811	biological_process	monoatomic ion transport
U	0015986	biological_process	proton motive force-driven ATP synthesis
U	0016887	molecular_function	ATP hydrolysis activity
U	0045259	cellular_component	proton-transporting ATP synthase complex
U	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
U	1902600	biological_process	proton transmembrane transport
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0006754	biological_process	ATP biosynthetic process
X	0006811	biological_process	monoatomic ion transport
X	0015078	molecular_function	proton transmembrane transporter activity
X	0015986	biological_process	proton motive force-driven ATP synthesis
X	0045259	cellular_component	proton-transporting ATP synthase complex
X	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
X	1902600	biological_process	proton transmembrane transport
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0006754	biological_process	ATP biosynthetic process
Y	0006811	biological_process	monoatomic ion transport
Y	0015986	biological_process	proton motive force-driven ATP synthesis
Y	0016020	cellular_component	membrane
Y	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Y	0045259	cellular_component	proton-transporting ATP synthase complex
Y	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Y	1902600	biological_process	proton transmembrane transport
Z	0015078	molecular_function	proton transmembrane transporter activity
Z	0015986	biological_process	proton motive force-driven ATP synthesis

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSKS

Chain	Residue	Details
D	PRO346-SER355
A	PRO365-SER374

---

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITnElvDiitGAsS

Chain	Residue	Details
G	ILE263-SER276

---

site_id	PS00389
Number of Residues	20
Details	ATPASE_DELTA ATP synthase delta (OSCP) subunit signature. LkLenvVKpEIkGGLIVElG

Chain	Residue	Details
Y	LEU153-GLY172

---

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLGSNI

Chain	Residue	Details
X	SER172-ILE181

---

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPsikdtVfPmaILgfaLsE

Chain	Residue	Details
K	SER38-GLU59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	355
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Site: {"description":"Reversibly protonated during proton transport","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Required for activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	35
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---