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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6COX

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 IN I222 SPACE GROUP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0001525biological_processangiogenesis
A0004601molecular_functionperoxidase activity
A0004666molecular_functionprostaglandin-endoperoxide synthase activity
A0005515molecular_functionprotein binding
A0005637cellular_componentnuclear inner membrane
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005901cellular_componentcaveola
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006693biological_processprostaglandin metabolic process
A0006979biological_processresponse to oxidative stress
A0007566biological_processembryo implantation
A0007612biological_processlearning
A0007613biological_processmemory
A0008015biological_processblood circulation
A0008217biological_processregulation of blood pressure
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0009624biological_processresponse to nematode
A0010269biological_processresponse to selenium ion
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0016491molecular_functionoxidoreductase activity
A0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0019371biological_processcyclooxygenase pathway
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0030216biological_processkeratinocyte differentiation
A0030282biological_processbone mineralization
A0031394biological_processpositive regulation of prostaglandin biosynthetic process
A0031622biological_processpositive regulation of fever generation
A0031915biological_processpositive regulation of synaptic plasticity
A0032227biological_processnegative regulation of synaptic transmission, dopaminergic
A0032310biological_processprostaglandin secretion
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0034097biological_processresponse to cytokine
A0035633biological_processmaintenance of blood-brain barrier
A0042127biological_processregulation of cell population proliferation
A0042307biological_processpositive regulation of protein import into nucleus
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045786biological_processnegative regulation of cell cycle
A0045907biological_processpositive regulation of vasoconstriction
A0045986biological_processnegative regulation of smooth muscle contraction
A0045987biological_processpositive regulation of smooth muscle contraction
A0046457biological_processprostanoid biosynthetic process
A0046697biological_processdecidualization
A0046872molecular_functionmetal ion binding
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050873biological_processbrown fat cell differentiation
A0051213molecular_functiondioxygenase activity
A0051926biological_processnegative regulation of calcium ion transport
A0051968biological_processpositive regulation of synaptic transmission, glutamatergic
A0071456biological_processcellular response to hypoxia
A0071471biological_processcellular response to non-ionic osmotic stress
A0071498biological_processcellular response to fluid shear stress
A0071636biological_processpositive regulation of transforming growth factor beta production
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0090271biological_processpositive regulation of fibroblast growth factor production
A0090336biological_processpositive regulation of brown fat cell differentiation
A0090362biological_processpositive regulation of platelet-derived growth factor production
A0098869biological_processcellular oxidant detoxification
A0150077biological_processregulation of neuroinflammatory response
A1902219biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
B0001516biological_processprostaglandin biosynthetic process
B0001525biological_processangiogenesis
B0004601molecular_functionperoxidase activity
B0004666molecular_functionprostaglandin-endoperoxide synthase activity
B0005515molecular_functionprotein binding
B0005637cellular_componentnuclear inner membrane
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005901cellular_componentcaveola
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006693biological_processprostaglandin metabolic process
B0006979biological_processresponse to oxidative stress
B0007566biological_processembryo implantation
B0007612biological_processlearning
B0007613biological_processmemory
B0008015biological_processblood circulation
B0008217biological_processregulation of blood pressure
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0009624biological_processresponse to nematode
B0010269biological_processresponse to selenium ion
B0010575biological_processpositive regulation of vascular endothelial growth factor production
B0016491molecular_functionoxidoreductase activity
B0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0019371biological_processcyclooxygenase pathway
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0030216biological_processkeratinocyte differentiation
B0030282biological_processbone mineralization
B0031394biological_processpositive regulation of prostaglandin biosynthetic process
B0031622biological_processpositive regulation of fever generation
B0031915biological_processpositive regulation of synaptic plasticity
B0032227biological_processnegative regulation of synaptic transmission, dopaminergic
B0032310biological_processprostaglandin secretion
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0034097biological_processresponse to cytokine
B0035633biological_processmaintenance of blood-brain barrier
B0042127biological_processregulation of cell population proliferation
B0042307biological_processpositive regulation of protein import into nucleus
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045786biological_processnegative regulation of cell cycle
B0045907biological_processpositive regulation of vasoconstriction
B0045986biological_processnegative regulation of smooth muscle contraction
B0045987biological_processpositive regulation of smooth muscle contraction
B0046457biological_processprostanoid biosynthetic process
B0046697biological_processdecidualization
B0046872molecular_functionmetal ion binding
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050873biological_processbrown fat cell differentiation
B0051213molecular_functiondioxygenase activity
B0051926biological_processnegative regulation of calcium ion transport
B0051968biological_processpositive regulation of synaptic transmission, glutamatergic
B0071456biological_processcellular response to hypoxia
B0071471biological_processcellular response to non-ionic osmotic stress
B0071498biological_processcellular response to fluid shear stress
B0071636biological_processpositive regulation of transforming growth factor beta production
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0090271biological_processpositive regulation of fibroblast growth factor production
B0090336biological_processpositive regulation of brown fat cell differentiation
B0090362biological_processpositive regulation of platelet-derived growth factor production
B0098869biological_processcellular oxidant detoxification
B0150077biological_processregulation of neuroinflammatory response
B1902219biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Functional Information from PDB Data
site_idACE
Number of Residues1
DetailsSER 530 IS ACETYLATED BY ASPIRIN (AN ACETYL GROUP IS COVALENTLY ATTACHED TO THE PROTEIN WHEN INHIBITED WITH ASPIRIN). THE ACETYLATED SER PREVENTS THE PROPER BINDING OF THE SUBSTRATE IN THE CYCLOOXYGENASE ACTIVE SITE. IT HAS BEEN RECENTLY SHOWN, HOWEVER, THAT ACETYLATION OF CYCLOOXYGENASE-2 RESULTS IN THE FORMATION OF A DIFFERENT PRODUCT (15-HETE).
ChainResidue
ASER530
site_idCAT
Number of Residues1
DetailsTYR 385 IS BELIEVED TO BE THE AMINO ACID THAT ABSTRACTS A HYDROGEN ATOM FROM THE SUBSTRATE. IT IS LOCATED CLOSE TO THE HEME. A TYROSINE RADICAL IS FORMED DURING THE COURSE OF THE REACTION.
ChainResidue
ATYR385
site_idHEM
Number of Residues1
DetailsHIS 388 IS THE AXIAL LIGAND TO THE HEME.
ChainResidue
AHIS388
site_idSUB
Number of Residues1
DetailsARGININE 120 IS BELIEVED TO ANCHOR THE CARBOXYLATE OF THE SUBSTRATE BY FORMING AN ION-PAIR.
ChainResidue
AARG120
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues74
DetailsDomain: {"description":"EGF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00298","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"For cyclooxygenase activity","evidences":[{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"12925531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20810665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21489986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8967954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PGH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6COX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Aspirin-acetylated serine"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P35354","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"O-acetylserine; by SPHK1","evidences":[{"source":"PubMed","id":"29662056","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000222","evidences":[{"source":"PubMed","id":"10811226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12925531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20810665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21467029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21489986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8349699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8967954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PGH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Z0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JVY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JVZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6COX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000223","evidences":[{"source":"PubMed","id":"10811226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12925531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20810665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21467029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21489986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8349699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8967954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OLU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PGH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Z0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JVY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JVZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6COX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000224","evidences":[{"source":"PubMed","id":"10811226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12925531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20463020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20810665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21467029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21489986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8349699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8967954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LN1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OLU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PGH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4Z0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5COX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JVY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JVZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6COX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1mhl
ChainResidueDetails
AVAL291
site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1mhl
ChainResidueDetails
BVAL291
site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1mhl
ChainResidueDetails
AHIS207
ATYR385
AGLN203
site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1mhl
ChainResidueDetails
BHIS207
BTYR385
BGLN203
site_idMCSA1
Number of Residues7
DetailsM-CSA 37
ChainResidueDetails
AGLN203electrostatic stabiliser, hydrogen bond donor
AHIS207electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
ALEU384steric role
ATYR385hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, radical stabiliser
AHIS388metal ligand
AGLY526steric role
ASER530electrostatic stabiliser
site_idMCSA2
Number of Residues7
DetailsM-CSA 37
ChainResidueDetails
BGLN203electrostatic stabiliser, hydrogen bond donor
BHIS207electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
BLEU384steric role
BTYR385hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, radical stabiliser
BHIS388metal ligand
BGLY526steric role
BSER530electrostatic stabiliser

246704

PDB entries from 2025-12-24

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