6CO1

Structure of human TIRR in complex with 53BP1 Tudor domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006402	biological_process	mRNA catabolic process
A	0016077	biological_process	sno(s)RNA catabolic process
A	0030515	molecular_function	snoRNA binding
A	0042803	molecular_function	protein homodimerization activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
A	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
A	2001033	biological_process	negative regulation of double-strand break repair via nonhomologous end joining
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006402	biological_process	mRNA catabolic process
B	0016077	biological_process	sno(s)RNA catabolic process
B	0030515	molecular_function	snoRNA binding
B	0042803	molecular_function	protein homodimerization activity
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
B	2001033	biological_process	negative regulation of double-strand break repair via nonhomologous end joining
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006402	biological_process	mRNA catabolic process
C	0016077	biological_process	sno(s)RNA catabolic process
C	0030515	molecular_function	snoRNA binding
C	0042803	molecular_function	protein homodimerization activity
C	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
C	2001033	biological_process	negative regulation of double-strand break repair via nonhomologous end joining
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006402	biological_process	mRNA catabolic process
D	0016077	biological_process	sno(s)RNA catabolic process
D	0030515	molecular_function	snoRNA binding
D	0042803	molecular_function	protein homodimerization activity
D	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
D	1990174	molecular_function	phosphodiesterase decapping endonuclease activity
D	2001033	biological_process	negative regulation of double-strand break repair via nonhomologous end joining

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	348
Details	Region: {"description":"Interaction with PXN","evidences":[{"source":"UniProtKB","id":"Q8VHN8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Required for interaction with TP53BP1","evidences":[{"source":"PubMed","id":"28241136","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28241136","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	119
Details	Region: {"description":"Tudor-like","evidences":[{"source":"PubMed","id":"17190600","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	56
Details	Region: {"description":"Interaction with dimethylated histone H4","evidences":[{"source":"PubMed","id":"17190600","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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