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6CNO

Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006813biological_processpotassium ion transport
A0006816biological_processcalcium ion transport
A0006884biological_processcell volume homeostasis
A0006952biological_processdefense response
A0008076cellular_componentvoltage-gated potassium channel complex
A0015269molecular_functioncalcium-activated potassium channel activity
A0016020cellular_componentmembrane
A0016286molecular_functionsmall conductance calcium-activated potassium channel activity
A0019903molecular_functionprotein phosphatase binding
A0022894molecular_functionintermediate conductance calcium-activated potassium channel activity
A0030322biological_processstabilization of membrane potential
A0031982cellular_componentvesicle
A0032587cellular_componentruffle membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0044351biological_processmacropinocytosis
A0045332biological_processphospholipid translocation
A0046541biological_processsaliva secretion
A0050714biological_processpositive regulation of protein secretion
A0050862biological_processpositive regulation of T cell receptor signaling pathway
A0051289biological_processprotein homotetramerization
A0051649biological_processestablishment of localization in cell
A0071805biological_processpotassium ion transmembrane transport
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1905664biological_processregulation of calcium ion import across plasma membrane
B0002376biological_processimmune system process
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006813biological_processpotassium ion transport
B0006816biological_processcalcium ion transport
B0006884biological_processcell volume homeostasis
B0006952biological_processdefense response
B0008076cellular_componentvoltage-gated potassium channel complex
B0015269molecular_functioncalcium-activated potassium channel activity
B0016020cellular_componentmembrane
B0016286molecular_functionsmall conductance calcium-activated potassium channel activity
B0019903molecular_functionprotein phosphatase binding
B0022894molecular_functionintermediate conductance calcium-activated potassium channel activity
B0030322biological_processstabilization of membrane potential
B0031982cellular_componentvesicle
B0032587cellular_componentruffle membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0044351biological_processmacropinocytosis
B0045332biological_processphospholipid translocation
B0046541biological_processsaliva secretion
B0050714biological_processpositive regulation of protein secretion
B0050862biological_processpositive regulation of T cell receptor signaling pathway
B0051289biological_processprotein homotetramerization
B0051649biological_processestablishment of localization in cell
B0071805biological_processpotassium ion transmembrane transport
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1905664biological_processregulation of calcium ion import across plasma membrane
C0002376biological_processimmune system process
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006813biological_processpotassium ion transport
C0006816biological_processcalcium ion transport
C0006884biological_processcell volume homeostasis
C0006952biological_processdefense response
C0008076cellular_componentvoltage-gated potassium channel complex
C0015269molecular_functioncalcium-activated potassium channel activity
C0016020cellular_componentmembrane
C0016286molecular_functionsmall conductance calcium-activated potassium channel activity
C0019903molecular_functionprotein phosphatase binding
C0022894molecular_functionintermediate conductance calcium-activated potassium channel activity
C0030322biological_processstabilization of membrane potential
C0031982cellular_componentvesicle
C0032587cellular_componentruffle membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0042803molecular_functionprotein homodimerization activity
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0044351biological_processmacropinocytosis
C0045332biological_processphospholipid translocation
C0046541biological_processsaliva secretion
C0050714biological_processpositive regulation of protein secretion
C0050862biological_processpositive regulation of T cell receptor signaling pathway
C0051289biological_processprotein homotetramerization
C0051649biological_processestablishment of localization in cell
C0071805biological_processpotassium ion transmembrane transport
C1901381biological_processpositive regulation of potassium ion transmembrane transport
C1905664biological_processregulation of calcium ion import across plasma membrane
D0002376biological_processimmune system process
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006813biological_processpotassium ion transport
D0006816biological_processcalcium ion transport
D0006884biological_processcell volume homeostasis
D0006952biological_processdefense response
D0008076cellular_componentvoltage-gated potassium channel complex
D0015269molecular_functioncalcium-activated potassium channel activity
D0016020cellular_componentmembrane
D0016286molecular_functionsmall conductance calcium-activated potassium channel activity
D0019903molecular_functionprotein phosphatase binding
D0022894molecular_functionintermediate conductance calcium-activated potassium channel activity
D0030322biological_processstabilization of membrane potential
D0031982cellular_componentvesicle
D0032587cellular_componentruffle membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0042803molecular_functionprotein homodimerization activity
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0044351biological_processmacropinocytosis
D0045332biological_processphospholipid translocation
D0046541biological_processsaliva secretion
D0050714biological_processpositive regulation of protein secretion
D0050862biological_processpositive regulation of T cell receptor signaling pathway
D0051289biological_processprotein homotetramerization
D0051649biological_processestablishment of localization in cell
D0071805biological_processpotassium ion transmembrane transport
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1905664biological_processregulation of calcium ion import across plasma membrane
E0000086biological_processG2/M transition of mitotic cell cycle
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0007186biological_processG protein-coupled receptor signaling pathway
E0008076cellular_componentvoltage-gated potassium channel complex
E0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
E0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031954biological_processpositive regulation of protein autophosphorylation
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032516biological_processpositive regulation of phosphoprotein phosphatase activity
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035307biological_processpositive regulation of protein dephosphorylation
E0035458biological_processcellular response to interferon-beta
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050848biological_processregulation of calcium-mediated signaling
E0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0098901biological_processregulation of cardiac muscle cell action potential
E0140056biological_processorganelle localization by membrane tethering
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0035458biological_processcellular response to interferon-beta
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F0140056biological_processorganelle localization by membrane tethering
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
G0000086biological_processG2/M transition of mitotic cell cycle
G0000922cellular_componentspindle pole
G0002027biological_processregulation of heart rate
G0005509molecular_functioncalcium ion binding
G0005513biological_processdetection of calcium ion
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005819cellular_componentspindle
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005876cellular_componentspindle microtubule
G0005886cellular_componentplasma membrane
G0007186biological_processG protein-coupled receptor signaling pathway
G0008076cellular_componentvoltage-gated potassium channel complex
G0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
G0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
G0010856molecular_functionadenylate cyclase activator activity
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016240biological_processautophagosome membrane docking
G0019855molecular_functioncalcium channel inhibitor activity
G0019901molecular_functionprotein kinase binding
G0021762biological_processsubstantia nigra development
G0030017cellular_componentsarcomere
G0031432molecular_functiontitin binding
G0031514cellular_componentmotile cilium
G0031954biological_processpositive regulation of protein autophosphorylation
G0031982cellular_componentvesicle
G0032465biological_processregulation of cytokinesis
G0032516biological_processpositive regulation of phosphoprotein phosphatase activity
G0032991cellular_componentprotein-containing complex
G0034704cellular_componentcalcium channel complex
G0035307biological_processpositive regulation of protein dephosphorylation
G0035458biological_processcellular response to interferon-beta
G0043209cellular_componentmyelin sheath
G0043539molecular_functionprotein serine/threonine kinase activator activity
G0044325molecular_functiontransmembrane transporter binding
G0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
G0046872molecular_functionmetal ion binding
G0048306molecular_functioncalcium-dependent protein binding
G0050848biological_processregulation of calcium-mediated signaling
G0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
G0051592biological_processresponse to calcium ion
G0055117biological_processregulation of cardiac muscle contraction
G0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
G0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
G0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
G0071346biological_processcellular response to type II interferon
G0071902biological_processpositive regulation of protein serine/threonine kinase activity
G0072542molecular_functionprotein phosphatase activator activity
G0097225cellular_componentsperm midpiece
G0098901biological_processregulation of cardiac muscle cell action potential
G0140056biological_processorganelle localization by membrane tethering
G1901842biological_processnegative regulation of high voltage-gated calcium channel activity
G1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
G1902494cellular_componentcatalytic complex
G1905913biological_processnegative regulation of calcium ion export across plasma membrane
G1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
H0000086biological_processG2/M transition of mitotic cell cycle
H0000922cellular_componentspindle pole
H0002027biological_processregulation of heart rate
H0005509molecular_functioncalcium ion binding
H0005513biological_processdetection of calcium ion
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005876cellular_componentspindle microtubule
H0005886cellular_componentplasma membrane
H0007186biological_processG protein-coupled receptor signaling pathway
H0008076cellular_componentvoltage-gated potassium channel complex
H0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
H0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
H0010856molecular_functionadenylate cyclase activator activity
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016240biological_processautophagosome membrane docking
H0019855molecular_functioncalcium channel inhibitor activity
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030017cellular_componentsarcomere
H0031432molecular_functiontitin binding
H0031514cellular_componentmotile cilium
H0031954biological_processpositive regulation of protein autophosphorylation
H0031982cellular_componentvesicle
H0032465biological_processregulation of cytokinesis
H0032516biological_processpositive regulation of phosphoprotein phosphatase activity
H0032991cellular_componentprotein-containing complex
H0034704cellular_componentcalcium channel complex
H0035307biological_processpositive regulation of protein dephosphorylation
H0035458biological_processcellular response to interferon-beta
H0043209cellular_componentmyelin sheath
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0044325molecular_functiontransmembrane transporter binding
H0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
H0046872molecular_functionmetal ion binding
H0048306molecular_functioncalcium-dependent protein binding
H0050848biological_processregulation of calcium-mediated signaling
H0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
H0051592biological_processresponse to calcium ion
H0055117biological_processregulation of cardiac muscle contraction
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
H0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
H0071346biological_processcellular response to type II interferon
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0072542molecular_functionprotein phosphatase activator activity
H0097225cellular_componentsperm midpiece
H0098901biological_processregulation of cardiac muscle cell action potential
H0140056biological_processorganelle localization by membrane tethering
H1901842biological_processnegative regulation of high voltage-gated calcium channel activity
H1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
H1902494cellular_componentcatalytic complex
H1905913biological_processnegative regulation of calcium ion export across plasma membrane
H1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CA E 201
ChainResidue
EASP20
EASP22
EASP24
ETHR26
EGLU31

site_idAC2
Number of Residues5
Detailsbinding site for residue CA E 202
ChainResidue
EGLU67
EASP56
EASP58
EASN60
ETHR62

site_idAC3
Number of Residues5
Detailsbinding site for residue CA E 203
ChainResidue
EASP93
EASP95
EASN97
ETYR99
EGLU104

site_idAC4
Number of Residues5
Detailsbinding site for residue CA F 201
ChainResidue
FASP20
FASP22
FASP24
FTHR26
FGLU31

site_idAC5
Number of Residues5
Detailsbinding site for residue CA F 202
ChainResidue
FASP56
FASP58
FASN60
FTHR62
FGLU67

site_idAC6
Number of Residues5
Detailsbinding site for residue CA F 203
ChainResidue
FASP93
FASP95
FASN97
FTYR99
FGLU104

site_idAC7
Number of Residues5
Detailsbinding site for residue CA G 201
ChainResidue
GASP20
GASP22
GASP24
GTHR26
GGLU31

site_idAC8
Number of Residues5
Detailsbinding site for residue CA G 202
ChainResidue
GASP56
GASP58
GASN60
GTHR62
GGLU67

site_idAC9
Number of Residues5
Detailsbinding site for residue CA G 203
ChainResidue
GASP93
GASP95
GASN97
GTYR99
GGLU104

site_idAD1
Number of Residues5
Detailsbinding site for residue CA H 201
ChainResidue
HASP20
HASP22
HASP24
HTHR26
HGLU31

site_idAD2
Number of Residues5
Detailsbinding site for residue CA H 202
ChainResidue
HASP56
HASP58
HASN60
HTHR62
HGLU67

site_idAD3
Number of Residues5
Detailsbinding site for residue CA H 203
ChainResidue
HASP93
HASP95
HASN97
HTYR99
HGLU104

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
EASP20-LEU32
EASP56-PHE68
EASP93-LEU105
EASP129-PHE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
AALA29-PHE49
EGLU67
FASP20
FASP22
FASP24
FTHR26
FGLU31
FASP56
FASP58
FASN60
FTHR62
BALA29-PHE49
FGLU67
GASP20
GASP22
GASP24
GTHR26
GGLU31
GASP56
GASP58
GASN60
GTHR62
CALA29-PHE49
GGLU67
HASP20
HASP22
HASP24
HTHR26
HGLU31
HASP56
HASP58
HASN60
HTHR62
DALA29-PHE49
HGLU67
EGLU31
EASP56
EASP58
EASN60
ETHR62

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
APHE59-PHE79
EGLU140
FASP93
FASP95
FASN97
FTYR99
FGLU104
FASP129
FASP131
FASP133
FGLN135
BPHE59-PHE79
FGLU140
GASP93
GASP95
GASN97
GTYR99
GGLU104
GASP129
GASP131
GASP133
GGLN135
CPHE59-PHE79
GGLU140
HASP93
HASP95
HASN97
HTYR99
HGLU104
HASP129
HASP131
HASP133
HGLN135
DPHE59-PHE79
HGLU140
EGLU104
EASP129
EASP131
EASP133
EGLN135

site_idSWS_FT_FI3
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
AILE108-VAL128
BILE108-VAL128
CILE108-VAL128
DILE108-VAL128

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S4 => ECO:0000255
ChainResidueDetails
AGLY143-VAL163
BGLY143-VAL163
CGLY143-VAL163
DGLY143-VAL163

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
ALEU207-GLU227
BLEU207-GLU227
CLEU207-GLU227
DLEU207-GLU227

site_idSWS_FT_FI6
Number of Residues80
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255
ChainResidueDetails
ALEU241-MET261
BLEU241-MET261
CLEU241-MET261
DLEU241-MET261

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
AILE265-VAL285
BILE265-VAL285
CILE265-VAL285
DILE265-VAL285

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphohistidine => ECO:0000269|PubMed:17157250
ChainResidueDetails
AHIS358
BHIS358
CHIS358
DHIS358

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ESER101
FSER101
GSER101
HSER101

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ETHR110
FTHR110
GTHR110
HTHR110

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ELYS115
FLYS115
GLYS115
HLYS115

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ETYR138
FTYR138
GTYR138
HTYR138

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ELYS21
FLYS21
GLYS21
HLYS21

223532

PDB entries from 2024-08-07

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