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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CM1

MT1-MMP HPX Domain with Blade 2 Loop Bound to Nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005576	cellular_component	extracellular region
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0042157	biological_process	lipoprotein metabolic process
C	0005576	cellular_component	extracellular region
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0042157	biological_process	lipoprotein metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PX4 A 601

Chain	Residue
B	PX4372
B	PX4377
B	PX4384

site_id	AC2
Number of Residues	4
Details	binding site for residue PX4 A 602

Chain	Residue
A	PX4603
A	PX4604
B	PX4372
B	PX4375

site_id	AC3
Number of Residues	4
Details	binding site for residue PX4 A 603

Chain	Residue
B	PX4354
B	PX4384
A	PX4602
A	PX4609

site_id	AC4
Number of Residues	5
Details	binding site for residue PX4 A 604

Chain	Residue
A	PX4602
A	PX4607
B	PX4376
B	PX4390
B	PX4392

site_id	AC5
Number of Residues	4
Details	binding site for residue PX4 A 605

Chain	Residue
A	PX4609
A	PX4610
B	PX4374
B	PX4379

site_id	AC6
Number of Residues	3
Details	binding site for residue PX4 A 606

Chain	Residue
A	PX4608
A	PX4610
C	PX4302

site_id	AC7
Number of Residues	4
Details	binding site for residue PX4 A 607

Chain	Residue
A	PX4604
A	PX4612
B	PX4392
B	PX4394

site_id	AC8
Number of Residues	5
Details	binding site for residue PX4 A 608

Chain	Residue
A	PX4606
A	PX4611
A	PX4612
B	PX4381
B	PX4389

site_id	AC9
Number of Residues	5
Details	binding site for residue PX4 A 609

Chain	Residue
A	PX4603
A	PX4605
A	PX4610
A	PX4643
B	PX4384

site_id	AD1
Number of Residues	7
Details	binding site for residue PX4 A 610

Chain	Residue
A	PX4605
A	PX4606
A	PX4609
A	PX4612
B	PX4379
B	PX4383
B	PX4389

site_id	AD2
Number of Residues	3
Details	binding site for residue PX4 A 611

Chain	Residue
A	PX4608
B	PX4388
B	PX4394

site_id	AD3
Number of Residues	5
Details	binding site for residue PX4 A 612

Chain	Residue
A	PX4607
A	PX4608
A	PX4610
A	PX4652
B	PX4389

site_id	AD4
Number of Residues	6
Details	binding site for residue PX4 A 613

Chain	Residue
A	PX4614
A	PX4615
A	PX4628
A	PX4631
C	PX4338
C	PX4345

site_id	AD5
Number of Residues	6
Details	binding site for residue PX4 A 614

Chain	Residue
A	PX4613
A	PX4628
B	PX4385
C	PX4336
C	PX4350
C	PX4355

site_id	AD6
Number of Residues	3
Details	binding site for residue PX4 A 615

Chain	Residue
A	PX4613
A	PX4629
C	PX4360

site_id	AD7
Number of Residues	5
Details	binding site for residue PX4 A 616

Chain	Residue
A	PX4623
A	PX4634
C	PX4337
C	PX4346
C	PX4356

site_id	AD8
Number of Residues	6
Details	binding site for residue PX4 A 617

Chain	Residue
A	PX4625
A	PX4637
A	PX4649
B	PX4352
C	PX4339
C	PX4355

site_id	AD9
Number of Residues	2
Details	binding site for residue PX4 A 618

Chain	Residue
A	PX4620
A	PX4633

site_id	AE1
Number of Residues	4
Details	binding site for residue PX4 A 619

Chain	Residue
A	PX4627
A	PX4632
B	PX4396
C	PX4363

site_id	AE2
Number of Residues	4
Details	binding site for residue PX4 A 620

Chain	Residue
A	PX4618
A	PX4636
C	PX4348
C	PX4351

site_id	AE3
Number of Residues	2
Details	binding site for residue PX4 A 621

Chain	Residue
A	PX4629
A	PX4636

site_id	AE4
Number of Residues	3
Details	binding site for residue PX4 A 622

Chain	Residue
A	PX4635
C	PX4339
C	PX4349

site_id	AE5
Number of Residues	5
Details	binding site for residue PX4 A 623

Chain	Residue
A	PX4616
A	PX4634
B	PX4398
C	PX4329
C	PX4354

site_id	AE6
Number of Residues	2
Details	binding site for residue PX4 A 624

Chain	Residue
C	PX4357
A	PX4639

site_id	AE7
Number of Residues	4
Details	binding site for residue PX4 A 625

Chain	Residue
A	PX4617
A	PX4637
B	PX4362
C	PX4355

site_id	AE8
Number of Residues	4
Details	binding site for residue PX4 A 626

Chain	Residue
A	PX4638
B	PX4373
C	PX4346
C	PX4362

site_id	AE9
Number of Residues	4
Details	binding site for residue PX4 A 627

Chain	Residue
A	PX4619
A	PX4643
C	PX4358
C	PX4361

site_id	AF1
Number of Residues	6
Details	binding site for residue PX4 A 628

Chain	Residue
A	PX4613
A	PX4614
A	PX4631
A	PX4637
A	PX4641
A	PX4642

site_id	AF2
Number of Residues	4
Details	binding site for residue PX4 A 629

Chain	Residue
A	PX4615
A	PX4621
A	PX4631
A	PX4646

site_id	AF3
Number of Residues	4
Details	binding site for residue PX4 A 630

Chain	Residue
A	PX4633
A	PX4636
A	PX4645
A	PX4648

site_id	AF4
Number of Residues	7
Details	binding site for residue PX4 A 631

Chain	Residue
A	PX4613
A	PX4628
A	PX4629
A	PX4642
A	PX4646
B	PX4363
C	PX4302

site_id	AF5
Number of Residues	5
Details	binding site for residue PX4 A 632

Chain	Residue
A	PX4619
A	PX4643
A	PX4647
B	PX4400
C	PX4363

site_id	AF6
Number of Residues	5
Details	binding site for residue PX4 A 633

Chain	Residue
A	PX4618
A	PX4630
A	PX4648
C	PX4362
C	PX4364

site_id	AF7
Number of Residues	5
Details	binding site for residue PX4 A 634

Chain	Residue
A	PX4616
A	PX4623
A	PX4640
A	PX4644
B	PX4398

site_id	AF8
Number of Residues	3
Details	binding site for residue PX4 A 635

Chain	Residue
A	PX4622
A	PX4637
C	PX4349

site_id	AF9
Number of Residues	5
Details	binding site for residue PX4 A 636

Chain	Residue
A	PX4620
A	PX4621
A	PX4630
A	PX4645
B	PX4382

site_id	AG1
Number of Residues	7
Details	binding site for residue PX4 A 637

Chain	Residue
A	PX4617
A	PX4625
A	PX4628
A	PX4635
A	PX4641
A	PX4649
B	PX4379

site_id	AG2
Number of Residues	4
Details	binding site for residue PX4 A 638

Chain	Residue
A	PX4626
A	PX4644
A	PX4648
C	PX4362

site_id	AG3
Number of Residues	3
Details	binding site for residue PX4 A 639

Chain	Residue
A	PX4624
A	PX4640
B	PX4355

site_id	AG4
Number of Residues	5
Details	binding site for residue PX4 A 640

Chain	Residue
A	GLN359
A	PX4634
A	PX4639
A	PX4650
B	PX4372

site_id	AG5
Number of Residues	5
Details	binding site for residue PX4 A 641

Chain	Residue
A	GLU405
A	ARG443
A	PX4628
A	PX4637
A	PX4651

site_id	AG6
Number of Residues	5
Details	binding site for residue PX4 A 642

Chain	Residue
A	PX4628
A	PX4631
A	PX4646
A	PX4651
A	PX4653

site_id	AG7
Number of Residues	4
Details	binding site for residue PX4 A 643

Chain	Residue
A	PX4609
A	PX4627
A	PX4632
A	PX4652

site_id	AG8
Number of Residues	8
Details	binding site for residue PX4 A 644

Chain	Residue
A	PHE360
A	GLU392
A	ALA393
A	PX4634
A	PX4638
A	PX4648
A	PX4650
A	PX4654

site_id	AG9
Number of Residues	5
Details	binding site for residue PX4 A 645

Chain	Residue
A	PX4630
A	PX4636
A	PX4646
A	PX4648
A	PX4653

site_id	AH1
Number of Residues	5
Details	binding site for residue PX4 A 646

Chain	Residue
A	PX4629
A	PX4631
A	PX4642
A	PX4645
A	PX4653

site_id	AH2
Number of Residues	4
Details	binding site for residue PX4 A 647

Chain	Residue
A	PX4632
A	PX4650
A	PX4652
A	PX4654

site_id	AH3
Number of Residues	6
Details	binding site for residue PX4 A 648

Chain	Residue
A	PX4630
A	PX4633
A	PX4638
A	PX4644
A	PX4645
A	PX4653

site_id	AH4
Number of Residues	6
Details	binding site for residue PX4 A 649

Chain	Residue
A	LYS401
A	HIS402
A	PX4617
A	PX4637
A	PX4651
A	PX4652

site_id	AH5
Number of Residues	7
Details	binding site for residue PX4 A 650

Chain	Residue
A	GLN359
A	PHE360
A	ARG362
A	PX4640
A	PX4644
A	PX4647
A	PX4654

site_id	AH6
Number of Residues	7
Details	binding site for residue PX4 A 651

Chain	Residue
A	TYR399
A	LYS401
A	ARG443
A	PX4641
A	PX4642
A	PX4649
A	PX4653

site_id	AH7
Number of Residues	9
Details	binding site for residue PX4 A 652

Chain	Residue
A	PRO397
A	GLY398
A	TYR399
A	PRO400
A	PX4612
A	PX4643
A	PX4647
A	PX4649
A	PX4654

site_id	AH8
Number of Residues	5
Details	binding site for residue PX4 A 653

Chain	Residue
A	PX4642
A	PX4645
A	PX4646
A	PX4648
A	PX4651

site_id	AH9
Number of Residues	5
Details	binding site for residue PX4 A 654

Chain	Residue
A	SER394
A	PX4644
A	PX4647
A	PX4650
A	PX4652

site_id	AI1
Number of Residues	5
Details	binding site for residue NA A 655

Chain	Residue
A	ASN369
A	THR370
A	ASP416
A	ARG464
A	CL656

site_id	AI2
Number of Residues	3
Details	binding site for residue CL A 656

Chain	Residue
A	ALA371
A	ARG464
A	NA655

site_id	AI3
Number of Residues	6
Details	binding site for residue PX4 B 301

Chain	Residue
B	TRP108
B	GLN109
B	PX4303
B	PX4304
C	PX4325
C	PX4334

site_id	AI4
Number of Residues	3
Details	binding site for residue PX4 B 302

Chain	Residue
B	SER164
B	GLY167
B	PX4307

site_id	AI5
Number of Residues	8
Details	binding site for residue PX4 B 303

Chain	Residue
B	GLN105
B	PX4301
B	PX4335
B	PX4340
B	PX4353
C	ARG210
C	PX4301
C	PX4334

site_id	AI6
Number of Residues	6
Details	binding site for residue PX4 B 304

Chain	Residue
B	GLN109
B	MET112
B	ARG116
B	PX4301
B	PX4340
B	PX4345

site_id	AI7
Number of Residues	7
Details	binding site for residue PX4 B 305

Chain	Residue
B	GLU76
B	GLU80
B	ARG83
B	PX4312
B	PX4323
B	PX4346
B	PX4356

site_id	AI8
Number of Residues	8
Details	binding site for residue PX4 B 306

Chain	Residue
B	SER189
B	ARG193
B	PX4313
B	PX4314
B	PX4339
B	PX4348
C	PX4320
C	PX4339

site_id	AI9
Number of Residues	5
Details	binding site for residue PX4 B 307

Chain	Residue
B	LEU166
B	PX4302
B	PX4318
B	PX4337
C	TYR137

site_id	AJ1
Number of Residues	5
Details	binding site for residue PX4 B 308

Chain	Residue
B	LEU90
B	LYS94
C	HIS221
C	PX4301
C	PX4359

site_id	AJ2
Number of Residues	6
Details	binding site for residue PX4 B 309

Chain	Residue
B	ALA152
B	ARG153
B	PX4315
B	PX4333
C	LEU159
C	PX4311

site_id	AJ3
Number of Residues	3
Details	binding site for residue PX4 B 310

Chain	Residue
B	ARG138
B	PX4319
B	PX4328

site_id	AJ4
Number of Residues	3
Details	binding site for residue PX4 B 311

Chain	Residue
B	ARG116
B	PX4345
C	PX4343

site_id	AJ5
Number of Residues	4
Details	binding site for residue PX4 B 312

Chain	Residue
B	PX4305
B	PX4317
B	PX4356
C	PX4333

site_id	AJ6
Number of Residues	6
Details	binding site for residue PX4 B 313

Chain	Residue
B	ARG193
B	GLN194
B	PX4306
B	PX4330
C	PX4320
C	PX4330

site_id	AJ7
Number of Residues	6
Details	binding site for residue PX4 B 314

Chain	Residue
B	ARG182
B	PX4306
B	PX4318
C	PX4308
C	PX4320
C	PX4339

site_id	AJ8
Number of Residues	5
Details	binding site for residue PX4 B 315

Chain	Residue
B	ARG145
B	PX4309
B	PX4328
B	PX4336
C	PX4311

site_id	AJ9
Number of Residues	5
Details	binding site for residue PX4 B 316

Chain	Residue
B	PX4321
B	PX4322
B	PX4344
B	PX4350
C	PX4358

site_id	AK1
Number of Residues	4
Details	binding site for residue PX4 B 317

Chain	Residue
B	ARG61
B	PX4312
B	PX4325
B	PX4331

site_id	AK2
Number of Residues	6
Details	binding site for residue PX4 B 318

Chain	Residue
B	ARG175
B	PX4307
B	PX4314
B	PX4348
C	PX4318
C	PX4320

site_id	AK3
Number of Residues	3
Details	binding site for residue PX4 B 319

Chain	Residue
B	PX4310
B	PX4320
B	PX4358

site_id	AK4
Number of Residues	3
Details	binding site for residue PX4 B 320

Chain	Residue
B	PX4319
B	PX4340
C	PX4307

site_id	AK5
Number of Residues	6
Details	binding site for residue PX4 B 321

Chain	Residue
B	LYS204
B	GLY207
B	GLY208
B	LEU211
B	PX4316
C	PX4342

site_id	AK6
Number of Residues	4
Details	binding site for residue PX4 B 322

Chain	Residue
B	LEU211
B	PX4316
B	PX4342
B	PX4350

site_id	AK7
Number of Residues	7
Details	binding site for residue PX4 B 323

Chain	Residue
B	THR79
B	ARG83
B	PX4305
B	PX4346
C	HIS221
C	LEU225
C	PX4317

site_id	AK8
Number of Residues	4
Details	binding site for residue PX4 B 324

Chain	Residue
B	PX4347
B	PX4351
B	PX4354
C	PX4319

site_id	AK9
Number of Residues	6
Details	binding site for residue PX4 B 325

Chain	Residue
B	TYR258
B	PX4317
B	PX4331
B	PX4357
C	PX4329
C	PX4337

site_id	AL1
Number of Residues	5
Details	binding site for residue PX4 B 326

Chain	Residue
B	LEU233
B	ARG237
B	PX4351
B	PX4355
B	PX4399

site_id	AL2
Number of Residues	7
Details	binding site for residue PX4 B 327

Chain	Residue
B	PHE247
B	LYS248
B	PHE251
B	PX4351
B	PX4354
C	PHE57
C	PX4335

site_id	AL3
Number of Residues	7
Details	binding site for residue PX4 B 328

Chain	Residue
B	TRP130
B	TYR137
B	ARG138
B	ARG145
B	PX4310
B	PX4315
C	MET170

site_id	AL4
Number of Residues	3
Details	binding site for residue PX4 B 329

Chain	Residue
B	LEU233
B	PX4332
B	PX4355

site_id	AL5
Number of Residues	5
Details	binding site for residue PX4 B 330

Chain	Residue
B	LEU200
B	PX4313
B	PX4339
B	PX4360
C	PX4330

site_id	AL6
Number of Residues	5
Details	binding site for residue PX4 B 331

Chain	Residue
B	SER55
B	SER58
B	PX4317
B	PX4325
C	PX4331

site_id	AL7
Number of Residues	8
Details	binding site for residue PX4 B 332

Chain	Residue
B	LEU222
B	SER223
B	SER226
B	PX4329
B	PX4342
B	PX4397
C	GLU78
C	PX4312

site_id	AL8
Number of Residues	4
Details	binding site for residue PX4 B 333

Chain	Residue
B	PX4309
B	PX4336
B	PX4337
B	PX4368

site_id	AL9
Number of Residues	6
Details	binding site for residue PX4 B 334

Chain	Residue
B	PX4339
B	PX4348
B	PX4352
B	PX4362
B	PX4385
C	PX4318

site_id	AM1
Number of Residues	3
Details	binding site for residue PX4 B 335

Chain	Residue
B	PX4303
B	PX4353
B	PX4364

site_id	AM2
Number of Residues	3
Details	binding site for residue PX4 B 336

Chain	Residue
B	PX4315
B	PX4333
B	PX4343

site_id	AM3
Number of Residues	4
Details	binding site for residue PX4 B 337

Chain	Residue
B	GLN160
B	PX4307
B	PX4333
B	PX4352

site_id	AM4
Number of Residues	2
Details	binding site for residue PX4 B 338

Chain	Residue
B	PX4343
B	PX4365

site_id	AM5
Number of Residues	6
Details	binding site for residue PX4 B 339

Chain	Residue
B	PX4306
B	PX4330
B	PX4334
B	PX4360
B	PX4362
C	PX4341

site_id	AM6
Number of Residues	5
Details	binding site for residue PX4 B 340

Chain	Residue
B	PX4303
B	PX4304
B	PX4320
B	PX4358
B	PX4370

site_id	AM7
Number of Residues	5
Details	binding site for residue PX4 B 341

Chain	Residue
B	PX4346
B	PX4359
B	PX4373
C	PX4322
C	PX4352

site_id	AM8
Number of Residues	4
Details	binding site for residue PX4 B 342

Chain	Residue
B	PX4322
B	PX4332
B	PX4350
B	PX4367

site_id	AM9
Number of Residues	4
Details	binding site for residue PX4 B 343

Chain	Residue
B	PX4336
B	PX4338
B	PX4363
B	PX4365

site_id	AN1
Number of Residues	5
Details	binding site for residue PX4 B 344

Chain	Residue
B	PX4316
B	PX4350
B	PX4360
B	PX4374
B	PX4379

site_id	AN2
Number of Residues	4
Details	binding site for residue PX4 B 345

Chain	Residue
B	PX4304
B	PX4311
B	PX4353
B	PX4369

site_id	AN3
Number of Residues	4
Details	binding site for residue PX4 B 346

Chain	Residue
B	PX4305
B	PX4323
B	PX4341
C	PX4301

site_id	AN4
Number of Residues	4
Details	binding site for residue PX4 B 347

Chain	Residue
B	PX4324
B	PX4354
B	PX4357
B	PX4372

site_id	AN5
Number of Residues	5
Details	binding site for residue PX4 B 348

Chain	Residue
B	PX4306
B	PX4318
B	PX4334
B	PX4352
B	PX4362

site_id	AN6
Number of Residues	2
Details	binding site for residue PX4 B 349

Chain	Residue
B	PX4373
C	PX4362

site_id	AN7
Number of Residues	6
Details	binding site for residue PX4 B 350

Chain	Residue
B	PX4316
B	PX4322
B	PX4342
B	PX4344
B	PX4367
B	PX4374

site_id	AN8
Number of Residues	5
Details	binding site for residue PX4 B 351

Chain	Residue
B	PX4324
B	PX4326
B	PX4327
B	PX4354
B	PX4355

site_id	AN9
Number of Residues	6
Details	binding site for residue PX4 B 352

Chain	Residue
A	PX4617
B	PX4334
B	PX4337
B	PX4348
B	PX4368
B	PX4385

site_id	AO1
Number of Residues	6
Details	binding site for residue PX4 B 353

Chain	Residue
B	PX4303
B	PX4335
B	PX4345
B	PX4364
B	PX4369
B	PX4382

site_id	AO2
Number of Residues	6
Details	binding site for residue PX4 B 354

Chain	Residue
A	PX4603
B	PX4324
B	PX4327
B	PX4347
B	PX4351
B	PX4372

site_id	AO3
Number of Residues	5
Details	binding site for residue PX4 B 355

Chain	Residue
A	PX4639
B	PX4326
B	PX4329
B	PX4351
B	PX4377

site_id	AO4
Number of Residues	3
Details	binding site for residue PX4 B 356

Chain	Residue
B	PX4305
B	PX4312
C	PX4333

site_id	AO5
Number of Residues	4
Details	binding site for residue PX4 B 357

Chain	Residue
B	PX4325
B	PX4347
B	PX4375
B	PX4398

site_id	AO6
Number of Residues	3
Details	binding site for residue PX4 B 358

Chain	Residue
B	PX4319
B	PX4340
B	PX4378

site_id	AO7
Number of Residues	4
Details	binding site for residue PX4 B 359

Chain	Residue
B	PX4341
B	PX4371
B	PX4373
B	PX4380

site_id	AO8
Number of Residues	6
Details	binding site for residue PX4 B 360

Chain	Residue
B	PX4330
B	PX4339
B	PX4344
B	PX4362
B	PX4366
B	PX4379

site_id	AO9
Number of Residues	2
Details	binding site for residue PX4 B 361

Chain	Residue
B	PX4363
B	PX4368

site_id	AP1
Number of Residues	8
Details	binding site for residue PX4 B 362

Chain	Residue
A	PX4625
B	PX4334
B	PX4339
B	PX4348
B	PX4360
B	PX4366
B	PX4379
B	PX4385

site_id	AP2
Number of Residues	6
Details	binding site for residue PX4 B 363

Chain	Residue
A	PX4631
B	PX4343
B	PX4361
B	PX4368
B	PX4381
C	PX4302

site_id	AP3
Number of Residues	5
Details	binding site for residue PX4 B 364

Chain	Residue
B	PX4335
B	PX4353
B	PX4382
C	PX4301
C	PX4303

site_id	AP4
Number of Residues	6
Details	binding site for residue PX4 B 365

Chain	Residue
B	PX4338
B	PX4343
B	PX4378
C	PX4302
C	PX4310
C	PX4324

site_id	AP5
Number of Residues	2
Details	binding site for residue PX4 B 366

Chain	Residue
B	PX4360
B	PX4362

site_id	AP6
Number of Residues	5
Details	binding site for residue PX4 B 367

Chain	Residue
B	PX4342
B	PX4350
B	PX4374
B	PX4377
B	PX4384

site_id	AP7
Number of Residues	5
Details	binding site for residue PX4 B 368

Chain	Residue
B	PX4333
B	PX4352
B	PX4361
B	PX4363
B	PX4381

site_id	AP8
Number of Residues	7
Details	binding site for residue PX4 B 369

Chain	Residue
B	PX4345
B	PX4353
B	PX4370
B	PX4382
B	PX4386
B	PX4388
C	PX4348

site_id	AP9
Number of Residues	4
Details	binding site for residue PX4 B 370

Chain	Residue
B	PX4340
B	PX4369
B	PX4386
C	PX4340

site_id	AQ1
Number of Residues	3
Details	binding site for residue PX4 B 371

Chain	Residue
B	PX4359
B	PX4380
C	PX4303

site_id	AQ2
Number of Residues	6
Details	binding site for residue PX4 B 372

Chain	Residue
A	PX4601
A	PX4602
A	PX4640
B	PX4347
B	PX4354
B	PX4375

site_id	AQ3
Number of Residues	6
Details	binding site for residue PX4 B 373

Chain	Residue
A	PX4626
B	PX4341
B	PX4349
B	PX4359
B	PX4380
B	PX4387

site_id	AQ4
Number of Residues	5
Details	binding site for residue PX4 B 374

Chain	Residue
A	PX4605
B	PX4344
B	PX4350
B	PX4367
B	PX4384

site_id	AQ5
Number of Residues	4
Details	binding site for residue PX4 B 375

Chain	Residue
A	PX4602
B	PX4357
B	PX4372
B	PX4376

site_id	AQ6
Number of Residues	4
Details	binding site for residue PX4 B 376

Chain	Residue
A	PX4604
B	PX4375
B	PX4387
B	PX4390

site_id	AQ7
Number of Residues	3
Details	binding site for residue PX4 B 377

Chain	Residue
A	PX4601
B	PX4355
B	PX4367

site_id	AQ8
Number of Residues	5
Details	binding site for residue PX4 B 378

Chain	Residue
B	PX4358
B	PX4365
B	PX4386
B	PX4388
C	PX4302

site_id	AQ9
Number of Residues	7
Details	binding site for residue PX4 B 379

Chain	Residue
A	PX4605
A	PX4610
A	PX4637
B	PX4344
B	PX4360
B	PX4362
B	PX4389

site_id	AR1
Number of Residues	4
Details	binding site for residue PX4 B 380

Chain	Residue
B	PX4359
B	PX4371
B	PX4373
B	PX4387

site_id	AR2
Number of Residues	4
Details	binding site for residue PX4 B 381

Chain	Residue
A	PX4608
B	PX4363
B	PX4368
B	PX4383

site_id	AR3
Number of Residues	7
Details	binding site for residue PX4 B 382

Chain	Residue
A	PX4636
B	PX4353
B	PX4364
B	PX4369
B	PX4388
B	PX4391
B	PX4393

site_id	AR4
Number of Residues	4
Details	binding site for residue PX4 B 383

Chain	Residue
A	PX4610
B	PX4381
B	PX4385
B	PX4389

site_id	AR5
Number of Residues	5
Details	binding site for residue PX4 B 384

Chain	Residue
A	PX4601
A	PX4603
A	PX4609
B	PX4367
B	PX4374

site_id	AR6
Number of Residues	5
Details	binding site for residue PX4 B 385

Chain	Residue
A	PX4614
B	PX4334
B	PX4352
B	PX4362
B	PX4383

site_id	AR7
Number of Residues	3
Details	binding site for residue PX4 B 386

Chain	Residue
B	PX4369
B	PX4370
B	PX4378

site_id	AR8
Number of Residues	5
Details	binding site for residue PX4 B 387

Chain	Residue
B	PX4373
B	PX4376
B	PX4380
B	PX4390
B	PX4392

site_id	AR9
Number of Residues	5
Details	binding site for residue PX4 B 388

Chain	Residue
A	PX4611
B	PX4369
B	PX4378
B	PX4382
B	PX4393

site_id	AS1
Number of Residues	5
Details	binding site for residue PX4 B 389

Chain	Residue
A	PX4608
A	PX4610
A	PX4612
B	PX4379
B	PX4383

site_id	AS2
Number of Residues	6
Details	binding site for residue PX4 B 390

Chain	Residue
A	PX4604
B	PX4376
B	PX4387
B	PX4392
B	PX4393
B	PX4394

site_id	AS3
Number of Residues	4
Details	binding site for residue PX4 B 391

Chain	Residue
B	PX4382
B	PX4394
C	PX4303
C	PX4351

site_id	AS4
Number of Residues	5
Details	binding site for residue PX4 B 392

Chain	Residue
A	PX4604
A	PX4607
B	PX4387
B	PX4390
B	PX4394

site_id	AS5
Number of Residues	4
Details	binding site for residue PX4 B 393

Chain	Residue
B	PX4382
B	PX4388
B	PX4390
B	PX4394

site_id	AS6
Number of Residues	6
Details	binding site for residue PX4 B 394

Chain	Residue
A	PX4607
A	PX4611
B	PX4390
B	PX4391
B	PX4392
B	PX4393

site_id	AS7
Number of Residues	2
Details	binding site for residue PX4 B 395

Chain	Residue
B	PX4396
C	PX4358

site_id	AS8
Number of Residues	3
Details	binding site for residue PX4 B 396

Chain	Residue
A	PX4619
B	PX4395
B	PX4397

site_id	AS9
Number of Residues	5
Details	binding site for residue PX4 B 397

Chain	Residue
B	PX4332
B	PX4396
C	PX4312
C	PX4347
C	PX4363

site_id	AT1
Number of Residues	6
Details	binding site for residue PX4 B 398

Chain	Residue
A	PX4623
A	PX4634
B	PX4357
C	PX4319
C	PX4335
C	PX4354

site_id	AT2
Number of Residues	3
Details	binding site for residue PX4 B 399

Chain	Residue
B	PX4326
C	PX4332
C	PX4357

site_id	AT3
Number of Residues	4
Details	binding site for residue PX4 B 400

Chain	Residue
A	PX4632
C	PX4326
C	PX4347
C	PX4363

site_id	AT4
Number of Residues	4
Details	binding site for residue PX4 C 301

Chain	Residue
B	PX4303
B	PX4308
B	PX4346
B	PX4364

site_id	AT5
Number of Residues	5
Details	binding site for residue PX4 C 302

Chain	Residue
A	PX4606
A	PX4631
B	PX4363
B	PX4365
B	PX4378

site_id	AT6
Number of Residues	3
Details	binding site for residue PX4 C 303

Chain	Residue
B	PX4364
B	PX4371
B	PX4391

site_id	AT7
Number of Residues	3
Details	binding site for residue PX4 C 304

Chain	Residue
C	GLU76
C	THR79
C	ARG83

site_id	AT8
Number of Residues	7
Details	binding site for residue PX4 C 305

Chain	Residue
C	HIS157
C	GLN160
C	GLU161
C	SER164
C	PX4311
C	PX4324
C	PX4338

site_id	AT9
Number of Residues	6
Details	binding site for residue PX4 C 306

Chain	Residue
B	LEU163
C	GLN149
C	PX4311
C	PX4321
C	PX4336
C	PX4350

site_id	AU1
Number of Residues	7
Details	binding site for residue PX4 C 307

Chain	Residue
B	TYR122
B	PHE126
B	PX4320
C	LEU181
C	PX4310
C	PX4340
C	PX4343

site_id	AU2
Number of Residues	4
Details	binding site for residue PX4 C 308

Chain	Residue
B	LEU185
B	PX4314
C	ARG138
C	PX4318

site_id	AU3
Number of Residues	4
Details	binding site for residue PX4 C 309

Chain	Residue
C	SER189
C	PX4315
C	PX4327
C	PX4343

site_id	AU4
Number of Residues	8
Details	binding site for residue PX4 C 310

Chain	Residue
B	PX4365
C	ARG171
C	ALA174
C	PX4307
C	PX4324
C	PX4338
C	PX4340
C	PX4360

site_id	AU5
Number of Residues	5
Details	binding site for residue PX4 C 311

Chain	Residue
B	PX4309
B	PX4315
C	PX4305
C	PX4306
C	PX4336

site_id	AU6
Number of Residues	5
Details	binding site for residue PX4 C 312

Chain	Residue
B	ALA218
B	PX4332
B	PX4397
C	LEU82
C	PX4314

site_id	AU7
Number of Residues	6
Details	binding site for residue PX4 C 313

Chain	Residue
C	SER250
C	PHE251
C	LEU255
C	PX4329
C	PX4337
C	PX4354

site_id	AU8
Number of Residues	4
Details	binding site for residue PX4 C 314

Chain	Residue
B	TYR214
C	LEU90
C	LYS94
C	PX4312

site_id	AU9
Number of Residues	5
Details	binding site for residue PX4 C 315

Chain	Residue
C	PX4309
C	PX4327
C	PX4343
C	PX4348
C	PX4353

site_id	AV1
Number of Residues	6
Details	binding site for residue PX4 C 316

Chain	Residue
B	LEU200
B	LEU203
C	GLN109
C	PX4330
C	PX4342
C	PX4349

site_id	AV2
Number of Residues	5
Details	binding site for residue PX4 C 317

Chain	Residue
B	PX4323
C	LEU222
C	SER223
C	LEU225
C	PX4344

site_id	AV3
Number of Residues	7
Details	binding site for residue PX4 C 318

Chain	Residue
B	PX4318
B	PX4334
C	MET134
C	VAL141
C	ARG145
C	PX4308
C	PX4321

site_id	AV4
Number of Residues	7
Details	binding site for residue PX4 C 319

Chain	Residue
B	GLN265
B	PX4324
B	PX4398
C	TYR258
C	GLN265
C	PX4329
C	PX4335

site_id	AV5
Number of Residues	7
Details	binding site for residue PX4 C 320

Chain	Residue
B	PX4306
B	PX4313
B	PX4314
B	PX4318
C	ARG116
C	PX4330
C	PX4341

site_id	AV6
Number of Residues	5
Details	binding site for residue PX4 C 321

Chain	Residue
C	ARG145
C	GLN149
C	PX4306
C	PX4318
C	PX4350

site_id	AV7
Number of Residues	5
Details	binding site for residue PX4 C 322

Chain	Residue
B	PX4341
C	TYR214
C	PX4325
C	PX4344
C	PX4351

site_id	AV8
Number of Residues	6
Details	binding site for residue PX4 C 323

Chain	Residue
B	ASN206
B	TYR214
C	VAL97
C	GLN98
C	GLN105
C	PX4342

site_id	AV9
Number of Residues	7
Details	binding site for residue PX4 C 324

Chain	Residue
B	PX4365
C	GLN160
C	MET170
C	ARG171
C	PX4305
C	PX4310
C	PX4338

site_id	AW1
Number of Residues	6
Details	binding site for residue PX4 C 325

Chain	Residue
B	PX4301
C	GLY207
C	ARG210
C	PX4322
C	PX4334
C	PX4359

site_id	AW2
Number of Residues	6
Details	binding site for residue PX4 C 326

Chain	Residue
B	PHE247
B	PX4400
C	ARG61
C	THR68
C	GLN69
C	TRP72

site_id	AW3
Number of Residues	3
Details	binding site for residue PX4 C 327

Chain	Residue
C	PX4309
C	PX4315
C	PX4359

site_id	AW4
Number of Residues	5
Details	binding site for residue PX4 C 328

Chain	Residue
C	LEU236
C	LEU240
C	PX4331
C	PX4333
C	PX4356

site_id	AW5
Number of Residues	7
Details	binding site for residue PX4 C 329

Chain	Residue
A	PX4623
B	PX4325
C	LEU255
C	TYR258
C	PX4313
C	PX4319
C	PX4354

site_id	AW6
Number of Residues	5
Details	binding site for residue PX4 C 330

Chain	Residue
B	PX4313
B	PX4330
C	GLU113
C	PX4316
C	PX4320

site_id	AW7
Number of Residues	6
Details	binding site for residue PX4 C 331

Chain	Residue
B	PHE57
B	PX4331
C	VAL243
C	LEU244
C	PX4328
C	PX4337

site_id	AW8
Number of Residues	3
Details	binding site for residue PX4 C 332

Chain	Residue
B	PX4399
C	PX4335
C	PX4357

site_id	AW9
Number of Residues	5
Details	binding site for residue PX4 C 333

Chain	Residue
B	PX4312
B	PX4356
C	SER226
C	PX4328
C	PX4352

site_id	AX1
Number of Residues	8
Details	binding site for residue PX4 C 334

Chain	Residue
B	TRP108
B	PX4301
B	PX4303
C	LEU200
C	LEU203
C	ARG210
C	PX4325
C	PX4359

site_id	AX2
Number of Residues	6
Details	binding site for residue PX4 C 335

Chain	Residue
B	PX4327
B	PX4398
C	SER55
C	GLN265
C	PX4319
C	PX4332

site_id	AX3
Number of Residues	4
Details	binding site for residue PX4 C 336

Chain	Residue
A	PX4614
C	PX4306
C	PX4311
C	PX4345

site_id	AX4
Number of Residues	6
Details	binding site for residue PX4 C 337

Chain	Residue
A	PX4616
B	PX4325
C	PX4313
C	PX4331
C	PX4354
C	PX4356

site_id	AX5
Number of Residues	6
Details	binding site for residue PX4 C 338

Chain	Residue
A	PX4613
C	ARG171
C	PX4305
C	PX4310
C	PX4324
C	PX4340

site_id	AX6
Number of Residues	5
Details	binding site for residue PX4 C 339

Chain	Residue
A	PX4617
A	PX4622
B	PX4306
B	PX4314
C	PX4341

site_id	AX7
Number of Residues	6
Details	binding site for residue PX4 C 340

Chain	Residue
B	PX4370
C	PX4307
C	PX4310
C	PX4338
C	PX4343
C	PX4360

site_id	AX8
Number of Residues	3
Details	binding site for residue PX4 C 341

Chain	Residue
B	PX4339
C	PX4320
C	PX4339

site_id	AX9
Number of Residues	4
Details	binding site for residue PX4 C 342

Chain	Residue
B	PX4321
C	GLN105
C	PX4316
C	PX4323

site_id	AY1
Number of Residues	6
Details	binding site for residue PX4 C 343

Chain	Residue
B	PX4311
C	PX4307
C	PX4309
C	PX4315
C	PX4340
C	PX4353

site_id	AY2
Number of Residues	5
Details	binding site for residue PX4 C 344

Chain	Residue
C	PX4317
C	PX4322
C	PX4351
C	PX4352
C	PX4364

site_id	AY3
Number of Residues	2
Details	binding site for residue PX4 C 345

Chain	Residue
A	PX4613
C	PX4336

site_id	AY4
Number of Residues	7
Details	binding site for residue PX4 C 346

Chain	Residue
A	PX4616
A	PX4626
C	LEU233
C	LEU236
C	PX4352
C	PX4356
C	PX4362

site_id	AY5
Number of Residues	4
Details	binding site for residue PX4 C 347

Chain	Residue
B	PX4397
B	PX4400
C	TRP72
C	PX4363

site_id	AY6
Number of Residues	5
Details	binding site for residue PX4 C 348

Chain	Residue
A	PX4620
B	PX4369
C	PX4315
C	PX4353
C	PX4359

site_id	AY7
Number of Residues	4
Details	binding site for residue PX4 C 349

Chain	Residue
A	PX4622
A	PX4635
C	PX4316
C	PX4361

site_id	AY8
Number of Residues	4
Details	binding site for residue PX4 C 350

Chain	Residue
A	PX4614
C	PX4306
C	PX4321
C	PX4355

site_id	AY9
Number of Residues	5
Details	binding site for residue PX4 C 351

Chain	Residue
A	PX4620
B	PX4391
C	PX4322
C	PX4344
C	PX4359

site_id	AZ1
Number of Residues	5
Details	binding site for residue PX4 C 352

Chain	Residue
B	PX4341
C	PX4333
C	PX4344
C	PX4346
C	PX4364

site_id	AZ2
Number of Residues	3
Details	binding site for residue PX4 C 353

Chain	Residue
C	PX4315
C	PX4343
C	PX4348

site_id	AZ3
Number of Residues	5
Details	binding site for residue PX4 C 354

Chain	Residue
A	PX4623
B	PX4398
C	PX4313
C	PX4329
C	PX4337

site_id	AZ4
Number of Residues	4
Details	binding site for residue PX4 C 355

Chain	Residue
A	PX4614
A	PX4617
A	PX4625
C	PX4350

site_id	AZ5
Number of Residues	5
Details	binding site for residue PX4 C 356

Chain	Residue
A	PX4616
C	PX4328
C	PX4337
C	PX4346
C	PX4362

site_id	AZ6
Number of Residues	3
Details	binding site for residue PX4 C 357

Chain	Residue
A	PX4624
B	PX4399
C	PX4332

site_id	AZ7
Number of Residues	4
Details	binding site for residue PX4 C 358

Chain	Residue
A	PX4627
B	PX4316
B	PX4395
C	PX4361

site_id	AZ8
Number of Residues	6
Details	binding site for residue PX4 C 359

Chain	Residue
B	PX4308
C	PX4325
C	PX4327
C	PX4334
C	PX4348
C	PX4351

site_id	AZ9
Number of Residues	3
Details	binding site for residue PX4 C 360

Chain	Residue
A	PX4615
C	PX4310
C	PX4340

site_id	BC1
Number of Residues	3
Details	binding site for residue PX4 C 361

Chain	Residue
A	PX4627
C	PX4349
C	PX4358

site_id	BC2
Number of Residues	6
Details	binding site for residue PX4 C 362

Chain	Residue
A	PX4626
A	PX4633
A	PX4638
B	PX4349
C	PX4346
C	PX4356

site_id	BC3
Number of Residues	5
Details	binding site for residue PX4 C 363

Chain	Residue
A	PX4619
A	PX4632
B	PX4397
B	PX4400
C	PX4347

site_id	BC4
Number of Residues	3
Details	binding site for residue PX4 C 364

Chain	Residue
A	PX4633
C	PX4344
C	PX4352

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. IGqfWrglPaSINTAY

Chain	Residue	Details
A	ILE357-TYR372

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Methionine sulfoxide => ECO:0000269\|PubMed:12576517

Chain	Residue	Details
B	MET86
B	MET134
C	MET86
C	MET134

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:8261628

Chain	Residue	Details
B	LYS261
C	LYS261

222624

PDB entries from 2024-07-17

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