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6CIY

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG069

Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue F3J A 201
ChainResidue
ATRP81
AASN140
AHOH311
AHOH329
AHOH374
AHOH375
APRO82
APHE83
AGLN85
ALEU92
AASP96
AILE100
ATYR139
ATYR139

site_idAC2
Number of Residues7
Detailsbinding site for residue EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH323
AHOH326

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 203
ChainResidue
ALYS57
AASP144
AASP145
AHOH355
AHOH413

site_idAC4
Number of Residues7
Detailsbinding site for residue NO3 A 204
ChainResidue
AGLN78
APHE79
ATRP81
APRO95
AASP96
ALYS99
AMET149

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

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PDB entries from 2024-07-24

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