6CIO
Pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica with lactyl-TPP bound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
A | 0006979 | biological_process | response to oxidative stress |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016903 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
A | 0019164 | molecular_function | pyruvate synthase activity |
A | 0022900 | biological_process | electron transport chain |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051536 | molecular_function | iron-sulfur cluster binding |
A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
B | 0006979 | biological_process | response to oxidative stress |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016903 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
B | 0019164 | molecular_function | pyruvate synthase activity |
B | 0022900 | biological_process | electron transport chain |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051536 | molecular_function | iron-sulfur cluster binding |
B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0005506 | molecular_function | iron ion binding |
C | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
C | 0006979 | biological_process | response to oxidative stress |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016903 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
C | 0019164 | molecular_function | pyruvate synthase activity |
C | 0022900 | biological_process | electron transport chain |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0051536 | molecular_function | iron-sulfur cluster binding |
C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0005506 | molecular_function | iron ion binding |
D | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
D | 0006979 | biological_process | response to oxidative stress |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016903 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
D | 0019164 | molecular_function | pyruvate synthase activity |
D | 0022900 | biological_process | electron transport chain |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0051536 | molecular_function | iron-sulfur cluster binding |
D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0005506 | molecular_function | iron ion binding |
E | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
E | 0006979 | biological_process | response to oxidative stress |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016903 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
E | 0019164 | molecular_function | pyruvate synthase activity |
E | 0022900 | biological_process | electron transport chain |
E | 0030976 | molecular_function | thiamine pyrophosphate binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0051536 | molecular_function | iron-sulfur cluster binding |
E | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0005506 | molecular_function | iron ion binding |
F | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
F | 0006979 | biological_process | response to oxidative stress |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016903 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
F | 0019164 | molecular_function | pyruvate synthase activity |
F | 0022900 | biological_process | electron transport chain |
F | 0030976 | molecular_function | thiamine pyrophosphate binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0051536 | molecular_function | iron-sulfur cluster binding |
F | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue SF4 A 1201 |
Chain | Residue |
A | TRP681 |
A | CYS686 |
A | ILE687 |
A | CYS689 |
A | ASN690 |
A | CYS692 |
A | ILE735 |
A | CYS752 |
A | LEU759 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue SF4 A 1202 |
Chain | Residue |
A | CYS696 |
A | ILE701 |
A | CYS742 |
A | THR743 |
A | CYS745 |
A | GLY746 |
A | CYS748 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue SF4 A 1203 |
Chain | Residue |
A | LYS456 |
A | ALA808 |
A | CYS809 |
A | CYS812 |
A | GLU814 |
A | CYS837 |
A | CYS1075 |
site_id | AC4 |
Number of Residues | 24 |
Details | binding site for residue TDL A 1204 |
Chain | Residue |
A | PRO27 |
A | ILE28 |
A | THR29 |
A | GLU62 |
A | ARG112 |
A | ILE121 |
A | GLU814 |
A | THR835 |
A | GLY836 |
A | CYS837 |
A | PHE866 |
A | GLU867 |
A | GLY966 |
A | ASP967 |
A | GLY968 |
A | TRP969 |
A | ILE973 |
A | THR995 |
A | VAL997 |
A | SER999 |
A | ASN1000 |
A | THR1001 |
A | MG1205 |
A | HOH1301 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue MG A 1205 |
Chain | Residue |
A | ASP967 |
A | THR995 |
A | VAL997 |
A | TDL1204 |
A | HOH1301 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 1206 |
Chain | Residue |
A | SER424 |
A | GLY426 |
A | THR427 |
A | VAL428 |
A | GLY429 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue SF4 B 1201 |
Chain | Residue |
B | CYS686 |
B | ILE687 |
B | CYS689 |
B | ASN690 |
B | CYS692 |
B | CYS752 |
B | PRO753 |
B | LEU759 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue SF4 B 1202 |
Chain | Residue |
B | CYS696 |
B | PRO697 |
B | ILE701 |
B | CYS742 |
B | THR743 |
B | CYS745 |
B | GLY746 |
B | CYS748 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue SF4 B 1203 |
Chain | Residue |
B | CYS809 |
B | CYS812 |
B | GLU814 |
B | CYS837 |
B | SER999 |
B | CYS1075 |
B | ILE1076 |
site_id | AD1 |
Number of Residues | 21 |
Details | binding site for residue TPP B 1204 |
Chain | Residue |
B | MG1205 |
B | HOH1309 |
B | PRO27 |
B | ILE28 |
B | GLU62 |
B | GLN86 |
B | GLU814 |
B | CYS837 |
B | PHE866 |
B | GLU867 |
B | GLY966 |
B | ASP967 |
B | GLY968 |
B | TRP969 |
B | ILE973 |
B | THR995 |
B | VAL997 |
B | TYR998 |
B | SER999 |
B | ASN1000 |
B | THR1001 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MG B 1205 |
Chain | Residue |
B | ASP967 |
B | THR995 |
B | VAL997 |
B | TPP1204 |
B | HOH1309 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 1206 |
Chain | Residue |
B | SER424 |
B | GLY426 |
B | THR427 |
B | VAL428 |
B | GLY429 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 1207 |
Chain | Residue |
B | TRP513 |
B | ARG521 |
F | LYS726 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for residue SF4 C 1201 |
Chain | Residue |
C | TRP681 |
C | CYS686 |
C | ILE687 |
C | CYS689 |
C | ASN690 |
C | CYS692 |
C | CYS752 |
C | ALA758 |
site_id | AD6 |
Number of Residues | 8 |
Details | binding site for residue SF4 C 1202 |
Chain | Residue |
C | CYS696 |
C | ILE701 |
C | VAL737 |
C | CYS742 |
C | THR743 |
C | CYS745 |
C | GLY746 |
C | CYS748 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue SF4 C 1203 |
Chain | Residue |
C | LYS456 |
C | CYS809 |
C | CYS812 |
C | GLU814 |
C | CYS837 |
C | TRP841 |
C | CYS1075 |
site_id | AD8 |
Number of Residues | 28 |
Details | binding site for residue TDL C 1204 |
Chain | Residue |
C | PRO27 |
C | ILE28 |
C | THR29 |
C | GLU62 |
C | GLN86 |
C | ARG112 |
C | ILE121 |
C | GLU814 |
C | THR835 |
C | GLY836 |
C | CYS837 |
C | PHE866 |
C | GLU867 |
C | GLY966 |
C | ASP967 |
C | GLY968 |
C | TRP969 |
C | ILE973 |
C | THR995 |
C | VAL997 |
C | TYR998 |
C | SER999 |
C | ASN1000 |
C | THR1001 |
C | MG1205 |
C | HOH1302 |
C | HOH1308 |
C | HOH1311 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue MG C 1205 |
Chain | Residue |
C | ASP967 |
C | THR995 |
C | VAL997 |
C | TDL1204 |
C | HOH1302 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue SO4 C 1206 |
Chain | Residue |
C | SER424 |
C | ASP425 |
C | GLY426 |
C | VAL428 |
C | GLY429 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue SF4 D 1201 |
Chain | Residue |
D | CYS686 |
D | ILE687 |
D | CYS689 |
D | ASN690 |
D | CYS692 |
D | CYS752 |
site_id | AE3 |
Number of Residues | 8 |
Details | binding site for residue SF4 D 1202 |
Chain | Residue |
D | PRO679 |
D | CYS696 |
D | ILE701 |
D | CYS742 |
D | THR743 |
D | CYS745 |
D | GLY746 |
D | CYS748 |
site_id | AE4 |
Number of Residues | 7 |
Details | binding site for residue SF4 D 1203 |
Chain | Residue |
D | CYS809 |
D | CYS812 |
D | GLU814 |
D | CYS837 |
D | SER999 |
D | CYS1075 |
D | ILE1076 |
site_id | AE5 |
Number of Residues | 25 |
Details | binding site for residue TDL D 1204 |
Chain | Residue |
D | PRO27 |
D | ILE28 |
D | THR29 |
D | GLU62 |
D | ARG112 |
D | ILE121 |
D | GLU814 |
D | THR835 |
D | GLY836 |
D | CYS837 |
D | PHE866 |
D | GLU867 |
D | GLY966 |
D | ASP967 |
D | GLY968 |
D | TRP969 |
D | ILE973 |
D | THR995 |
D | VAL997 |
D | TYR998 |
D | SER999 |
D | ASN1000 |
D | THR1001 |
D | MG1205 |
D | HOH1306 |
site_id | AE6 |
Number of Residues | 5 |
Details | binding site for residue MG D 1205 |
Chain | Residue |
D | ASP967 |
D | THR995 |
D | VAL997 |
D | TDL1204 |
D | HOH1306 |
site_id | AE7 |
Number of Residues | 6 |
Details | binding site for residue SO4 D 1206 |
Chain | Residue |
D | SER424 |
D | ASP425 |
D | GLY426 |
D | THR427 |
D | VAL428 |
D | GLY429 |
site_id | AE8 |
Number of Residues | 8 |
Details | binding site for residue SF4 E 1201 |
Chain | Residue |
E | CYS686 |
E | ILE687 |
E | CYS689 |
E | ASN690 |
E | CYS692 |
E | CYS752 |
E | PRO753 |
E | ALA758 |
site_id | AE9 |
Number of Residues | 7 |
Details | binding site for residue SF4 E 1202 |
Chain | Residue |
E | CYS696 |
E | ILE701 |
E | CYS742 |
E | THR743 |
E | CYS745 |
E | GLY746 |
E | CYS748 |
site_id | AF1 |
Number of Residues | 7 |
Details | binding site for residue SF4 E 1203 |
Chain | Residue |
E | CYS809 |
E | CYS812 |
E | GLU814 |
E | CYS837 |
E | CYS1075 |
E | ILE1076 |
E | ASN1077 |
site_id | AF2 |
Number of Residues | 22 |
Details | binding site for residue TPP E 1204 |
Chain | Residue |
E | PRO27 |
E | ILE28 |
E | GLU62 |
E | GLN86 |
E | GLU814 |
E | GLY836 |
E | CYS837 |
E | PHE866 |
E | GLU867 |
E | GLY966 |
E | ASP967 |
E | GLY968 |
E | TRP969 |
E | ILE973 |
E | THR995 |
E | VAL997 |
E | TYR998 |
E | SER999 |
E | ASN1000 |
E | THR1001 |
E | MG1205 |
E | HOH1308 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for residue MG E 1205 |
Chain | Residue |
E | ASP967 |
E | THR995 |
E | VAL997 |
E | TPP1204 |
E | HOH1308 |
site_id | AF4 |
Number of Residues | 5 |
Details | binding site for residue SO4 E 1206 |
Chain | Residue |
E | SER424 |
E | ASP425 |
E | GLY426 |
E | VAL428 |
E | GLY429 |
site_id | AF5 |
Number of Residues | 7 |
Details | binding site for residue SF4 F 1201 |
Chain | Residue |
F | TRP681 |
F | CYS686 |
F | ILE687 |
F | CYS689 |
F | ASN690 |
F | CYS692 |
F | CYS752 |
site_id | AF6 |
Number of Residues | 8 |
Details | binding site for residue SF4 F 1202 |
Chain | Residue |
F | CYS696 |
F | ILE701 |
F | VAL737 |
F | CYS742 |
F | THR743 |
F | CYS745 |
F | GLY746 |
F | CYS748 |
site_id | AF7 |
Number of Residues | 6 |
Details | binding site for residue SF4 F 1203 |
Chain | Residue |
F | LYS456 |
F | CYS809 |
F | CYS812 |
F | GLU814 |
F | CYS837 |
F | CYS1075 |
site_id | AF8 |
Number of Residues | 25 |
Details | binding site for residue TDL F 1204 |
Chain | Residue |
F | PRO27 |
F | ILE28 |
F | THR29 |
F | GLU62 |
F | ARG112 |
F | ILE121 |
F | GLU814 |
F | THR835 |
F | GLY836 |
F | CYS837 |
F | PHE866 |
F | GLU867 |
F | GLY966 |
F | ASP967 |
F | GLY968 |
F | TRP969 |
F | ILE973 |
F | THR995 |
F | VAL997 |
F | TYR998 |
F | SER999 |
F | ASN1000 |
F | THR1001 |
F | MG1205 |
F | HOH1304 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue MG F 1205 |
Chain | Residue |
F | ASP967 |
F | THR995 |
F | VAL997 |
F | TDL1204 |
F | HOH1304 |
site_id | AG1 |
Number of Residues | 6 |
Details | binding site for residue SO4 F 1206 |
Chain | Residue |
F | SER424 |
F | ASP425 |
F | GLY426 |
F | THR427 |
F | VAL428 |
F | GLY429 |
Functional Information from PROSITE/UniProt
site_id | PS00198 |
Number of Residues | 12 |
Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiQCNqCSlVCP |
Chain | Residue | Details |
A | CYS686-PRO697 | |
A | CYS742-PRO753 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000305|PubMed:29581263, ECO:0000312|PDB:6CIO |
Chain | Residue | Details |
A | THR29 | |
D | THR29 | |
D | ARG112 | |
D | ASN1000 | |
E | THR29 | |
E | ARG112 | |
E | ASN1000 | |
F | THR29 | |
F | ARG112 | |
F | ASN1000 | |
A | ARG112 | |
A | ASN1000 | |
B | THR29 | |
B | ARG112 | |
B | ASN1000 | |
C | THR29 | |
C | ARG112 | |
C | ASN1000 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29581263, ECO:0000312|PDB:6CIQ |
Chain | Residue | Details |
A | SER424 | |
C | LYS456 | |
C | ASN556 | |
C | ASN598 | |
D | SER424 | |
D | LYS456 | |
D | ASN556 | |
D | ASN598 | |
E | SER424 | |
E | LYS456 | |
E | ASN556 | |
A | LYS456 | |
E | ASN598 | |
F | SER424 | |
F | LYS456 | |
F | ASN556 | |
F | ASN598 | |
A | ASN556 | |
A | ASN598 | |
B | SER424 | |
B | LYS456 | |
B | ASN556 | |
B | ASN598 | |
C | SER424 |
site_id | SWS_FT_FI3 |
Number of Residues | 90 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29581263, ECO:0000312|PDB:6CIN |
Chain | Residue | Details |
A | CYS686 | |
A | CYS812 | |
A | CYS837 | |
A | ASP967 | |
A | THR995 | |
A | VAL997 | |
A | CYS1075 | |
B | CYS686 | |
B | CYS689 | |
B | CYS692 | |
B | CYS696 | |
A | CYS689 | |
B | CYS742 | |
B | CYS745 | |
B | CYS748 | |
B | CYS752 | |
B | CYS809 | |
B | CYS812 | |
B | CYS837 | |
B | ASP967 | |
B | THR995 | |
B | VAL997 | |
A | CYS692 | |
B | CYS1075 | |
C | CYS686 | |
C | CYS689 | |
C | CYS692 | |
C | CYS696 | |
C | CYS742 | |
C | CYS745 | |
C | CYS748 | |
C | CYS752 | |
C | CYS809 | |
A | CYS696 | |
C | CYS812 | |
C | CYS837 | |
C | ASP967 | |
C | THR995 | |
C | VAL997 | |
C | CYS1075 | |
D | CYS686 | |
D | CYS689 | |
D | CYS692 | |
D | CYS696 | |
A | CYS742 | |
D | CYS742 | |
D | CYS745 | |
D | CYS748 | |
D | CYS752 | |
D | CYS809 | |
D | CYS812 | |
D | CYS837 | |
D | ASP967 | |
D | THR995 | |
D | VAL997 | |
A | CYS745 | |
D | CYS1075 | |
E | CYS686 | |
E | CYS689 | |
E | CYS692 | |
E | CYS696 | |
E | CYS742 | |
E | CYS745 | |
E | CYS748 | |
E | CYS752 | |
E | CYS809 | |
A | CYS748 | |
E | CYS812 | |
E | CYS837 | |
E | ASP967 | |
E | THR995 | |
E | VAL997 | |
E | CYS1075 | |
F | CYS686 | |
F | CYS689 | |
F | CYS692 | |
F | CYS696 | |
A | CYS752 | |
F | CYS742 | |
F | CYS745 | |
F | CYS748 | |
F | CYS752 | |
F | CYS809 | |
F | CYS812 | |
F | CYS837 | |
F | ASP967 | |
F | THR995 | |
F | VAL997 | |
A | CYS809 | |
F | CYS1075 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29581263, ECO:0000312|PDB:6CIO |
Chain | Residue | Details |
A | GLU814 | |
B | GLU814 | |
C | GLU814 | |
D | GLU814 | |
E | GLU814 | |
F | GLU814 |