Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CIN

Crystal structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005506	molecular_function	iron ion binding
A	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
A	0019164	molecular_function	pyruvate synthase activity
A	0022900	biological_process	electron transport chain
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0046872	molecular_function	metal ion binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0003824	molecular_function	catalytic activity
B	0005506	molecular_function	iron ion binding
B	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
B	0006979	biological_process	response to oxidative stress
B	0016491	molecular_function	oxidoreductase activity
B	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
B	0019164	molecular_function	pyruvate synthase activity
B	0022900	biological_process	electron transport chain
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0046872	molecular_function	metal ion binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0003824	molecular_function	catalytic activity
C	0005506	molecular_function	iron ion binding
C	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
C	0019164	molecular_function	pyruvate synthase activity
C	0022900	biological_process	electron transport chain
C	0030976	molecular_function	thiamine pyrophosphate binding
C	0046872	molecular_function	metal ion binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0003824	molecular_function	catalytic activity
D	0005506	molecular_function	iron ion binding
D	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
D	0006979	biological_process	response to oxidative stress
D	0016491	molecular_function	oxidoreductase activity
D	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
D	0019164	molecular_function	pyruvate synthase activity
D	0022900	biological_process	electron transport chain
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0046872	molecular_function	metal ion binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0003824	molecular_function	catalytic activity
E	0005506	molecular_function	iron ion binding
E	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
E	0006979	biological_process	response to oxidative stress
E	0016491	molecular_function	oxidoreductase activity
E	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
E	0019164	molecular_function	pyruvate synthase activity
E	0022900	biological_process	electron transport chain
E	0030976	molecular_function	thiamine pyrophosphate binding
E	0046872	molecular_function	metal ion binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0003824	molecular_function	catalytic activity
F	0005506	molecular_function	iron ion binding
F	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
F	0006979	biological_process	response to oxidative stress
F	0016491	molecular_function	oxidoreductase activity
F	0016903	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors
F	0019164	molecular_function	pyruvate synthase activity
F	0022900	biological_process	electron transport chain
F	0030976	molecular_function	thiamine pyrophosphate binding
F	0046872	molecular_function	metal ion binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SF4 A 1201

Chain	Residue
A	TRP681
A	CYS686
A	ILE687
A	CYS689
A	ASN690
A	CYS692
A	CYS752
A	LEU759

site_id	AC2
Number of Residues	7
Details	binding site for residue SF4 A 1202

Chain	Residue
A	ILE701
A	CYS742
A	THR743
A	CYS745
A	GLY746
A	CYS748
A	CYS696

site_id	AC3
Number of Residues	7
Details	binding site for residue SF4 A 1203

Chain	Residue
A	LYS456
A	ALA808
A	CYS809
A	CYS812
A	GLU814
A	CYS837
A	CYS1075

site_id	AC4
Number of Residues	24
Details	binding site for residue TPP A 1204

Chain	Residue
A	PRO27
A	ILE28
A	GLU62
A	GLU814
A	THR835
A	GLY836
A	CYS837
A	PHE866
A	GLU867
A	GLY966
A	ASP967
A	GLY968
A	TRP969
A	ILE973
A	THR995
A	VAL997
A	SER999
A	ASN1000
A	THR1001
A	MG1205
A	HOH1314
A	HOH1318
A	HOH1352
A	HOH1362

site_id	AC5
Number of Residues	5
Details	binding site for residue MG A 1205

Chain	Residue
A	ASP967
A	THR995
A	VAL997
A	TPP1204
A	HOH1318

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 1206

Chain	Residue
A	SER424
A	GLY426
A	THR427
A	VAL428
A	GLY429

site_id	AC7
Number of Residues	8
Details	binding site for residue SF4 B 1201

Chain	Residue
B	CYS686
B	ILE687
B	CYS689
B	ASN690
B	CYS692
B	CYS752
B	PRO753
B	LEU759

site_id	AC8
Number of Residues	8
Details	binding site for residue SF4 B 1202

Chain	Residue
B	PRO679
B	CYS696
B	ILE701
B	CYS742
B	THR743
B	CYS745
B	GLY746
B	CYS748

site_id	AC9
Number of Residues	9
Details	binding site for residue SF4 B 1203

Chain	Residue
B	LYS456
B	CYS809
B	CYS812
B	GLU814
B	CYS837
B	SER999
B	CYS1075
B	ILE1076
B	MET1082

site_id	AD1
Number of Residues	24
Details	binding site for residue TPP B 1204

Chain	Residue
B	SER999
B	ASN1000
B	THR1001
B	MG1205
B	HOH1306
B	HOH1323
B	PRO27
B	ILE28
B	GLU62
B	GLN86
B	GLU814
B	THR835
B	GLY836
B	CYS837
B	PHE866
B	GLU867
B	GLY966
B	ASP967
B	GLY968
B	TRP969
B	ILE973
B	THR995
B	VAL997
B	TYR998

site_id	AD2
Number of Residues	5
Details	binding site for residue MG B 1205

Chain	Residue
B	ASP967
B	THR995
B	VAL997
B	TPP1204
B	HOH1323

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 B 1206

Chain	Residue
B	SER424
B	GLY426
B	THR427
B	VAL428
B	GLY429
B	HOH1324

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 B 1207

Chain	Residue
B	TRP513
B	ARG521
D	LYS726

site_id	AD5
Number of Residues	7
Details	binding site for residue SF4 C 1201

Chain	Residue
C	CYS686
C	ILE687
C	CYS689
C	ASN690
C	CYS692
C	CYS752
C	LEU759

site_id	AD6
Number of Residues	7
Details	binding site for residue SF4 C 1202

Chain	Residue
C	CYS696
C	ILE701
C	CYS742
C	THR743
C	CYS745
C	GLY746
C	CYS748

site_id	AD7
Number of Residues	5
Details	binding site for residue SF4 C 1203

Chain	Residue
C	CYS809
C	CYS812
C	GLU814
C	CYS837
C	CYS1075

site_id	AD8
Number of Residues	24
Details	binding site for residue TPP C 1204

Chain	Residue
C	PRO27
C	GLU62
C	GLN86
C	GLU814
C	THR835
C	CYS837
C	PHE866
C	GLU867
C	GLY966
C	ASP967
C	GLY968
C	TRP969
C	ILE973
C	THR995
C	VAL997
C	TYR998
C	SER999
C	ASN1000
C	THR1001
C	MG1205
C	HOH1330
C	HOH1334
C	HOH1352
C	HOH1370

site_id	AD9
Number of Residues	5
Details	binding site for residue MG C 1205

Chain	Residue
C	ASP967
C	THR995
C	VAL997
C	TPP1204
C	HOH1352

site_id	AE1
Number of Residues	7
Details	binding site for residue SO4 C 1206

Chain	Residue
C	SER424
C	GLY426
C	THR427
C	VAL428
C	GLY429
C	HOH1302
C	HOH1305

site_id	AE2
Number of Residues	9
Details	binding site for residue SF4 D 1201

Chain	Residue
D	TRP681
D	CYS686
D	ILE687
D	CYS689
D	ASN690
D	CYS692
D	CYS752
D	ALA758
D	LEU759

site_id	AE3
Number of Residues	9
Details	binding site for residue SF4 D 1202

Chain	Residue
D	PRO679
D	CYS696
D	ILE701
D	VAL737
D	CYS742
D	THR743
D	CYS745
D	GLY746
D	CYS748

site_id	AE4
Number of Residues	7
Details	binding site for residue SF4 D 1203

Chain	Residue
D	ALA808
D	CYS809
D	CYS812
D	GLU814
D	CYS837
D	CYS1075
D	MET1082

site_id	AE5
Number of Residues	27
Details	binding site for residue TPP D 1204

Chain	Residue
D	PRO27
D	ILE28
D	GLU62
D	GLN86
D	LEU90
D	GLU814
D	THR835
D	GLY836
D	CYS837
D	PHE866
D	GLU867
D	GLY966
D	ASP967
D	GLY968
D	TRP969
D	ILE973
D	THR995
D	VAL997
D	TYR998
D	SER999
D	ASN1000
D	THR1001
D	MG1205
D	HOH1304
D	HOH1329
D	HOH1340
D	HOH1377

site_id	AE6
Number of Residues	5
Details	binding site for residue MG D 1205

Chain	Residue
D	ASP967
D	THR995
D	VAL997
D	TPP1204
D	HOH1329

site_id	AE7
Number of Residues	6
Details	binding site for residue SO4 D 1206

Chain	Residue
D	SER424
D	ASP425
D	GLY426
D	THR427
D	VAL428
D	GLY429

site_id	AE8
Number of Residues	7
Details	binding site for residue SF4 E 1201

Chain	Residue
E	TRP681
E	CYS686
E	ILE687
E	CYS689
E	ASN690
E	CYS692
E	CYS752

site_id	AE9
Number of Residues	8
Details	binding site for residue SF4 E 1202

Chain	Residue
E	PRO679
E	CYS696
E	ILE701
E	CYS742
E	THR743
E	CYS745
E	GLY746
E	CYS748

site_id	AF1
Number of Residues	6
Details	binding site for residue SF4 E 1203

Chain	Residue
E	LYS456
E	CYS809
E	CYS812
E	GLU814
E	CYS837
E	CYS1075

site_id	AF2
Number of Residues	23
Details	binding site for residue TPP E 1204

Chain	Residue
E	PRO27
E	ILE28
E	GLU62
E	GLU814
E	THR835
E	GLY836
E	CYS837
E	PHE866
E	GLU867
E	GLY966
E	ASP967
E	GLY968
E	TRP969
E	ILE973
E	THR995
E	VAL997
E	SER999
E	ASN1000
E	MG1205
E	HOH1306
E	HOH1315
E	HOH1328
E	HOH1347

site_id	AF3
Number of Residues	5
Details	binding site for residue MG E 1205

Chain	Residue
E	ASP967
E	THR995
E	VAL997
E	TPP1204
E	HOH1306

site_id	AF4
Number of Residues	7
Details	binding site for residue SO4 E 1206

Chain	Residue
E	SER424
E	ASP425
E	GLY426
E	THR427
E	VAL428
E	GLY429
E	HOH1302

site_id	AF5
Number of Residues	7
Details	binding site for residue SF4 F 1201

Chain	Residue
F	CYS686
F	ILE687
F	CYS689
F	ASN690
F	CYS692
F	CYS752
F	ALA758

site_id	AF6
Number of Residues	7
Details	binding site for residue SF4 F 1202

Chain	Residue
F	CYS696
F	ILE701
F	CYS742
F	THR743
F	CYS745
F	GLY746
F	CYS748

site_id	AF7
Number of Residues	6
Details	binding site for residue SF4 F 1203

Chain	Residue
F	LYS456
F	CYS809
F	CYS812
F	GLU814
F	CYS837
F	CYS1075

site_id	AF8
Number of Residues	25
Details	binding site for residue TPP F 1204

Chain	Residue
F	PRO27
F	ILE28
F	GLU62
F	GLN86
F	GLU814
F	THR835
F	GLY836
F	CYS837
F	PHE866
F	GLU867
F	GLY966
F	ASP967
F	GLY968
F	TRP969
F	ILE973
F	THR995
F	VAL997
F	TYR998
F	SER999
F	ASN1000
F	THR1001
F	MG1205
F	HOH1306
F	HOH1331
F	HOH1346

site_id	AF9
Number of Residues	5
Details	binding site for residue MG F 1205

Chain	Residue
F	ASP967
F	THR995
F	VAL997
F	TPP1204
F	HOH1331

site_id	AG1
Number of Residues	5
Details	binding site for residue SO4 F 1206

Chain	Residue
F	SER424
F	ASP425
F	GLY426
F	VAL428
F	GLY429

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiQCNqCSlVCP

Chain	Residue	Details
A	CYS686-PRO697
A	CYS742-PRO753

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000305\|PubMed:29581263, ECO:0000312\|PDB:6CIO

Chain	Residue	Details
A	THR29
D	THR29
D	ARG112
D	ASN1000
E	THR29
E	ARG112
E	ASN1000
F	THR29
F	ARG112
F	ASN1000
A	ARG112
A	ASN1000
B	THR29
B	ARG112
B	ASN1000
C	THR29
C	ARG112
C	ASN1000

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:29581263, ECO:0000312\|PDB:6CIQ

Chain	Residue	Details
A	SER424
C	LYS456
C	ASN556
C	ASN598
D	SER424
D	LYS456
D	ASN556
D	ASN598
E	SER424
E	LYS456
E	ASN556
A	LYS456
E	ASN598
F	SER424
F	LYS456
F	ASN556
F	ASN598
A	ASN556
A	ASN598
B	SER424
B	LYS456
B	ASN556
B	ASN598
C	SER424

site_id	SWS_FT_FI3
Number of Residues	90
Details	BINDING: BINDING => ECO:0000269\|PubMed:29581263, ECO:0000312\|PDB:6CIN

Chain	Residue	Details
A	CYS686
A	CYS812
A	CYS837
A	ASP967
A	THR995
A	VAL997
A	CYS1075
B	CYS686
B	CYS689
B	CYS692
B	CYS696
A	CYS689
B	CYS742
B	CYS745
B	CYS748
B	CYS752
B	CYS809
B	CYS812
B	CYS837
B	ASP967
B	THR995
B	VAL997
A	CYS692
B	CYS1075
C	CYS686
C	CYS689
C	CYS692
C	CYS696
C	CYS742
C	CYS745
C	CYS748
C	CYS752
C	CYS809
A	CYS696
C	CYS812
C	CYS837
C	ASP967
C	THR995
C	VAL997
C	CYS1075
D	CYS686
D	CYS689
D	CYS692
D	CYS696
A	CYS742
D	CYS742
D	CYS745
D	CYS748
D	CYS752
D	CYS809
D	CYS812
D	CYS837
D	ASP967
D	THR995
D	VAL997
A	CYS745
D	CYS1075
E	CYS686
E	CYS689
E	CYS692
E	CYS696
E	CYS742
E	CYS745
E	CYS748
E	CYS752
E	CYS809
A	CYS748
E	CYS812
E	CYS837
E	ASP967
E	THR995
E	VAL997
E	CYS1075
F	CYS686
F	CYS689
F	CYS692
F	CYS696
A	CYS752
F	CYS742
F	CYS745
F	CYS748
F	CYS752
F	CYS809
F	CYS812
F	CYS837
F	ASP967
F	THR995
F	VAL997
A	CYS809
F	CYS1075

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:29581263, ECO:0000312\|PDB:6CIO

Chain	Residue	Details
A	GLU814
B	GLU814
C	GLU814
D	GLU814
E	GLU814
F	GLU814

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)