6CI0

Catalytic core subunits (I and II) of cytochrome C oxidase from Rhodobacter sphaeroides with E101A (II) mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006119	biological_process	oxidative phosphorylation
C	0009060	biological_process	aerobic respiration
C	0015990	biological_process	electron transport coupled proton transport
C	0016020	cellular_component	membrane
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0045277	cellular_component	respiratory chain complex IV
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0004129	molecular_function	cytochrome-c oxidase activity
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0022900	biological_process	electron transport chain
D	0042773	biological_process	ATP synthesis coupled electron transport
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiivlpafgivshviatfakkpifgylpmvyamvaigvlgfvvwa..HH

Chain	Residue	Details
A	TRP280-HIS334

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site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHswtvpafgvkqdavpgrlaqlwfraeregiffgq......CselCgisHayM

Chain	Residue	Details
B	VAL215-MET263

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	PHE60-VAL80
A	PHE420-ILE440
A	LEU455-GLY475
A	LEU499-LEU519
C	ILE29-VAL49
C	VAL97-GLY117
C	LEU141-GLY161
C	LEU189-ILE209
C	LEU227-ALA247
C	ILE278-VAL298
C	ILE310-VAL330
B	TRP104-PHE124
C	PHE348-ALA368
C	MET381-LEU401
C	PHE420-ILE440
C	LEU455-GLY475
C	LEU499-LEU519
D	PHE60-VAL80
D	TRP104-PHE124
A	LEU227-ALA247
A	ILE278-VAL298
A	ILE310-VAL330
A	PHE348-ALA368
A	MET381-LEU401

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
B	HIS217
B	CYS252
B	CYS256
B	HIS260
D	HIS217
D	CYS252
D	CYS256
D	HIS260

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	HIS284
A	TYR288
A	HIS333
A	HIS334
C	HIS284
C	TYR288
C	HIS333
C	HIS334

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250

Chain	Residue	Details
A	HIS284
A	TYR288
C	HIS284
C	TYR288

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