6CHS
Cdc48-Npl4 complex in the presence of ATP-gamma-S
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0015031 | biological_process | protein transport |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0043130 | molecular_function | ubiquitin binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0030970 | biological_process | retrograde protein transport, ER to cytosol |
| D | 0031593 | molecular_function | polyubiquitin modification-dependent protein binding |
| D | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| D | 0051228 | biological_process | mitotic spindle disassembly |
| D | 0051301 | biological_process | cell division |
| D | 0097352 | biological_process | autophagosome maturation |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0030970 | biological_process | retrograde protein transport, ER to cytosol |
| E | 0031593 | molecular_function | polyubiquitin modification-dependent protein binding |
| E | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| E | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| E | 0051228 | biological_process | mitotic spindle disassembly |
| E | 0051301 | biological_process | cell division |
| E | 0097352 | biological_process | autophagosome maturation |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0030970 | biological_process | retrograde protein transport, ER to cytosol |
| F | 0031593 | molecular_function | polyubiquitin modification-dependent protein binding |
| F | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| F | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| F | 0051228 | biological_process | mitotic spindle disassembly |
| F | 0051301 | biological_process | cell division |
| F | 0097352 | biological_process | autophagosome maturation |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016887 | molecular_function | ATP hydrolysis activity |
| H | 0030970 | biological_process | retrograde protein transport, ER to cytosol |
| H | 0031593 | molecular_function | polyubiquitin modification-dependent protein binding |
| H | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| H | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| H | 0051228 | biological_process | mitotic spindle disassembly |
| H | 0051301 | biological_process | cell division |
| H | 0097352 | biological_process | autophagosome maturation |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005634 | cellular_component | nucleus |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0016887 | molecular_function | ATP hydrolysis activity |
| I | 0030970 | biological_process | retrograde protein transport, ER to cytosol |
| I | 0031593 | molecular_function | polyubiquitin modification-dependent protein binding |
| I | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| I | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| I | 0051228 | biological_process | mitotic spindle disassembly |
| I | 0051301 | biological_process | cell division |
| I | 0097352 | biological_process | autophagosome maturation |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005634 | cellular_component | nucleus |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0016887 | molecular_function | ATP hydrolysis activity |
| J | 0030970 | biological_process | retrograde protein transport, ER to cytosol |
| J | 0031593 | molecular_function | polyubiquitin modification-dependent protein binding |
| J | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| J | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| J | 0051228 | biological_process | mitotic spindle disassembly |
| J | 0051301 | biological_process | cell division |
| J | 0097352 | biological_process | autophagosome maturation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS160 |
| A | HIS162 |
| A | CYS168 |
| A | CYS171 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 702 |
| Chain | Residue |
| A | CYS227 |
| A | HIS231 |
| A | CYS239 |
| A | LYS241 |
| A | CYS242 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue AGS H 901 |
| Chain | Residue |
| F | ARG375 |
| F | PHE376 |
| H | ILE222 |
| H | GLY264 |
| H | THR265 |
| H | GLY266 |
| H | LYS267 |
| H | THR268 |
| H | LEU269 |
| H | ASN364 |
| H | HIS400 |
| H | GLY424 |
| H | SER425 |
| H | MG903 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue AGS H 902 |
| Chain | Residue |
| H | PRO537 |
| H | GLY538 |
| H | THR539 |
| H | GLY540 |
| H | LYS541 |
| H | THR542 |
| H | MET543 |
| H | ASN641 |
| H | ILE673 |
| H | GLN677 |
| H | GLY701 |
| H | ALA702 |
| H | MG904 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG H 903 |
| Chain | Residue |
| H | THR268 |
| H | ASP320 |
| H | AGS901 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MG H 904 |
| Chain | Residue |
| H | THR542 |
| H | AGS902 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue AGS I 901 |
| Chain | Residue |
| H | ARG375 |
| H | PHE376 |
| I | ILE222 |
| I | PRO263 |
| I | GLY264 |
| I | THR265 |
| I | GLY266 |
| I | LYS267 |
| I | THR268 |
| I | LEU269 |
| I | ASN364 |
| I | GLY424 |
| I | SER425 |
| I | MG903 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue AGS I 902 |
| Chain | Residue |
| I | PRO537 |
| I | GLY538 |
| I | THR539 |
| I | GLY540 |
| I | LYS541 |
| I | THR542 |
| I | MET543 |
| I | ASN641 |
| I | ILE673 |
| I | GLN677 |
| I | GLY701 |
| I | ALA702 |
| I | MG904 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue MG I 903 |
| Chain | Residue |
| I | THR268 |
| I | ASP320 |
| I | AGS901 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue MG I 904 |
| Chain | Residue |
| I | THR542 |
| I | AGS902 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for residue AGS J 901 |
| Chain | Residue |
| J | ILE222 |
| J | PRO263 |
| J | GLY264 |
| J | THR265 |
| J | GLY266 |
| J | LYS267 |
| J | THR268 |
| J | LEU269 |
| J | ASN364 |
| J | ILE396 |
| J | HIS400 |
| J | GLY424 |
| J | SER425 |
| J | MG903 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for residue AGS J 902 |
| Chain | Residue |
| J | MG904 |
| J | PRO537 |
| J | GLY538 |
| J | THR539 |
| J | GLY540 |
| J | LYS541 |
| J | THR542 |
| J | MET543 |
| J | ASN641 |
| J | ILE673 |
| J | GLN677 |
| J | GLY701 |
| J | ALA702 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MG J 903 |
| Chain | Residue |
| J | THR268 |
| J | ASP320 |
| J | AGS901 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue MG J 904 |
| Chain | Residue |
| J | THR542 |
| J | AGS902 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue AGS D 901 |
| Chain | Residue |
| D | ILE222 |
| D | PRO263 |
| D | GLY264 |
| D | THR265 |
| D | GLY266 |
| D | LYS267 |
| D | THR268 |
| D | LEU269 |
| D | ASN364 |
| D | ILE396 |
| D | GLY424 |
| D | SER425 |
| D | MG903 |
| J | ARG375 |
| J | PHE376 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residue AGS D 902 |
| Chain | Residue |
| D | PRO537 |
| D | GLY538 |
| D | THR539 |
| D | GLY540 |
| D | LYS541 |
| D | THR542 |
| D | MET543 |
| D | ASN641 |
| D | ILE673 |
| D | GLN677 |
| D | GLY701 |
| D | ALA702 |
| D | MG904 |
| J | ARG652 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 903 |
| Chain | Residue |
| D | THR268 |
| D | ASP320 |
| D | AGS901 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 904 |
| Chain | Residue |
| D | THR542 |
| D | ASP594 |
| D | AGS902 |
| site_id | AE1 |
| Number of Residues | 15 |
| Details | binding site for residue AGS E 901 |
| Chain | Residue |
| D | ARG375 |
| E | ILE222 |
| E | PRO263 |
| E | GLY264 |
| E | THR265 |
| E | GLY266 |
| E | LYS267 |
| E | THR268 |
| E | LEU269 |
| E | ASN364 |
| E | ILE396 |
| E | HIS400 |
| E | GLY424 |
| E | SER425 |
| E | MG903 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for residue AGS E 902 |
| Chain | Residue |
| E | PRO537 |
| E | GLY538 |
| E | THR539 |
| E | GLY540 |
| E | LYS541 |
| E | THR542 |
| E | MET543 |
| E | ASN641 |
| E | ILE673 |
| E | GLN677 |
| E | GLY701 |
| E | ALA702 |
| E | MG904 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 903 |
| Chain | Residue |
| E | THR268 |
| E | ASP320 |
| E | AGS901 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 904 |
| Chain | Residue |
| E | THR542 |
| E | AGS902 |
| site_id | AE5 |
| Number of Residues | 14 |
| Details | binding site for residue AGS F 901 |
| Chain | Residue |
| E | PHE376 |
| F | ILE222 |
| F | GLY223 |
| F | GLY264 |
| F | THR265 |
| F | GLY266 |
| F | LYS267 |
| F | THR268 |
| F | LEU269 |
| F | ILE396 |
| F | HIS400 |
| F | GLY424 |
| F | SER425 |
| F | MG903 |
| site_id | AE6 |
| Number of Residues | 14 |
| Details | binding site for residue AGS F 902 |
| Chain | Residue |
| F | ILE496 |
| F | GLY497 |
| F | GLY538 |
| F | THR539 |
| F | GLY540 |
| F | LYS541 |
| F | THR542 |
| F | MET543 |
| F | ASN641 |
| F | ILE673 |
| F | GLN677 |
| F | GLY701 |
| F | ALA702 |
| F | MG904 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 903 |
| Chain | Residue |
| F | THR268 |
| F | ASP320 |
| F | AGS901 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue MG F 904 |
| Chain | Residue |
| F | THR542 |
| F | AGS902 |
Functional Information from PROSITE/UniProt
| site_id | PS00430 |
| Number of Residues | 78 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mapeskdhkkkvnltdpsgaehreendtatailkkkkkpnqlmvtdavnddnsiialsnntmealqlfrg.............................................DTVLVRGK |
| Chain | Residue | Details |
| H | MET1-LYS78 |
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. VvVMaATNrpnsIDpALr.R |
| Chain | Residue | Details |
| H | VAL357-ARG375 | |
| H | VAL634-ARG652 |
