6CFW

cryoEM structure of a respiratory membrane-bound hydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0015075	molecular_function	monoatomic ion transmembrane transporter activity
B	0015385	molecular_function	sodium:proton antiporter activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
C	0015297	molecular_function	antiporter activity
C	0015385	molecular_function	sodium:proton antiporter activity
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0098662	biological_process	inorganic cation transmembrane transport
D	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0015297	molecular_function	antiporter activity
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
F	0005886	cellular_component	plasma membrane
G	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
I	0016020	cellular_component	membrane
J	0005886	cellular_component	plasma membrane
J	0008901	molecular_function	ferredoxin hydrogenase activity
J	0009375	cellular_component	ferredoxin hydrogenase complex
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0016491	molecular_function	oxidoreductase activity
J	0046872	molecular_function	metal ion binding
J	0051536	molecular_function	iron-sulfur cluster binding
J	0051539	molecular_function	4 iron, 4 sulfur cluster binding
K	0005886	cellular_component	plasma membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0008901	molecular_function	ferredoxin hydrogenase activity
K	0009375	cellular_component	ferredoxin hydrogenase complex
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016491	molecular_function	oxidoreductase activity
K	0046872	molecular_function	metal ion binding
K	0055085	biological_process	transmembrane transport
L	0016151	molecular_function	nickel cation binding
L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
L	0048038	molecular_function	quinone binding
L	0051287	molecular_function	NAD binding
M	0005886	cellular_component	plasma membrane
M	0016020	cellular_component	membrane
N	0003954	molecular_function	NADH dehydrogenase activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
N	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SF4 J 201

Chain	Residue
J	SER34
J	CYS35
J	CYS38
J	ALA101
J	CYS102
J	CYS132

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site_id	AC2
Number of Residues	8
Details	binding site for residue NFU L 401

Chain	Residue
L	ARG320
L	PRO344
L	THR345
L	CYS374
L	CYS377
L	CYS68
L	CYS71
L	HIS75

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site_id	AC3
Number of Residues	7
Details	binding site for residue SF4 N 201

Chain	Residue
N	CYS56
N	PRO57
N	CYS77
N	MET79
N	CYS80
N	LYS81
N	CYS83

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site_id	AC4
Number of Residues	9
Details	binding site for residue SF4 N 202

Chain	Residue
N	CYS46
N	VAL47
N	GLY48
N	CYS49
N	ARG50
N	MET51
N	CYS52
N	CYS87
N	LEU92

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Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CvGCRmCVtVCP

Chain	Residue	Details
N	CYS46-PRO57
N	CYS77-PRO88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P12944

Chain	Residue	Details
L	CYS68
L	CYS71
L	CYS374
L	CYS377

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