6CFT
Structure of Human alpha-Phosphomannomutase 1 containing mutations R180T and R183I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004615 | molecular_function | phosphomannomutase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0009298 | biological_process | GDP-mannose biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ASP19 |
| A | ASP21 |
| A | ASN218 |
| A | HOH404 |
| A | HOH430 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | THR235 |
| A | GLU168 |
| A | PHE230 |
| A | ALA231 |
| A | ASP232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:16540464 |
| Chain | Residue | Details |
| A | ASP19 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:16540464 |
| Chain | Residue | Details |
| A | ASP21 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16540464, ECO:0007744|PDB:2FUC, ECO:0007744|PDB:2FUE |
| Chain | Residue | Details |
| A | ASP19 | |
| A | ASP21 | |
| A | ASN218 | |
| A | PHE230 | |
| A | ASP232 | |
| A | THR235 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16540464 |
| Chain | Residue | Details |
| A | ARG28 | |
| A | ARG132 | |
| A | ARG143 | |
| A | ARG150 | |
| A | MET186 | |
| A | SER188 | |
| A | ASP190 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35621 |
| Chain | Residue | Details |
| A | SER242 |
