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6CET

Cryo-EM structure of GATOR1

Functional Information from GO Data
ChainGOidnamespacecontents
D0005096molecular_functionGTPase activator activity
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0010508biological_processpositive regulation of autophagy
D0016020cellular_componentmembrane
D0031267molecular_functionsmall GTPase binding
D0031463cellular_componentCul3-RING ubiquitin ligase complex
D0034198biological_processcellular response to amino acid starvation
D0035556biological_processintracellular signal transduction
D0044877molecular_functionprotein-containing complex binding
D0048471cellular_componentperinuclear region of cytoplasm
D1904262biological_processnegative regulation of TORC1 signaling
D1990130cellular_componentGATOR1 complex
M0003281biological_processventricular septum development
M0005096molecular_functionGTPase activator activity
M0005515molecular_functionprotein binding
M0005764cellular_componentlysosome
M0005765cellular_componentlysosomal membrane
M0010508biological_processpositive regulation of autophagy
M0016020cellular_componentmembrane
M0032007biological_processnegative regulation of TOR signaling
M0034198biological_processcellular response to amino acid starvation
M0035909biological_processaorta morphogenesis
M0038202biological_processTORC1 signaling
M0048738biological_processcardiac muscle tissue development
M0060021biological_processroof of mouth development
M1904262biological_processnegative regulation of TORC1 signaling
M1990130cellular_componentGATOR1 complex
N0005096molecular_functionGTPase activator activity
N0005515molecular_functionprotein binding
N0005764cellular_componentlysosome
N0005765cellular_componentlysosomal membrane
N0005774cellular_componentvacuolar membrane
N0010508biological_processpositive regulation of autophagy
N0016020cellular_componentmembrane
N0033673biological_processnegative regulation of kinase activity
N0034198biological_processcellular response to amino acid starvation
N1904262biological_processnegative regulation of TORC1 signaling
N1990130cellular_componentGATOR1 complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER505

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PIM1 => ECO:0000269|PubMed:31548394
ChainResidueDetails
DSER1002

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKB/AKT1 and PIM1 => ECO:0000269|PubMed:31548394
ChainResidueDetails
DSER1530

site_idSWS_FT_FI4
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36528027
ChainResidueDetails
NLYS158
NLYS357

223532

PDB entries from 2024-08-07

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