6CET
Cryo-EM structure of GATOR1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0005096 | molecular_function | GTPase activator activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005764 | cellular_component | lysosome |
| D | 0005765 | cellular_component | lysosomal membrane |
| D | 0005829 | cellular_component | cytosol |
| D | 0010508 | biological_process | positive regulation of autophagy |
| D | 0031267 | molecular_function | small GTPase binding |
| D | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| D | 0034198 | biological_process | cellular response to amino acid starvation |
| D | 0035556 | biological_process | intracellular signal transduction |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 1904262 | biological_process | negative regulation of TORC1 signaling |
| D | 1990130 | cellular_component | GATOR1 complex |
| M | 0005096 | molecular_function | GTPase activator activity |
| M | 0005515 | molecular_function | protein binding |
| M | 0005765 | cellular_component | lysosomal membrane |
| M | 0010508 | biological_process | positive regulation of autophagy |
| M | 0032007 | biological_process | negative regulation of TOR signaling |
| M | 0034198 | biological_process | cellular response to amino acid starvation |
| M | 1904262 | biological_process | negative regulation of TORC1 signaling |
| M | 1990130 | cellular_component | GATOR1 complex |
| N | 0005096 | molecular_function | GTPase activator activity |
| N | 0005515 | molecular_function | protein binding |
| N | 0005765 | cellular_component | lysosomal membrane |
| N | 0005774 | cellular_component | vacuolar membrane |
| N | 0033673 | biological_process | negative regulation of kinase activity |
| N | 0034198 | biological_process | cellular response to amino acid starvation |
| N | 1904262 | biological_process | negative regulation of TORC1 signaling |
| N | 1990130 | cellular_component | GATOR1 complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"30651352","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"38006878","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36528027","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 33 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
