6CD0
Crystal structure of Medicago truncatula serine hydroxymethyltransferase 3 (MtSHMT3), PLP-internal aldimine and apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0019264 | biological_process | glycine biosynthetic process from serine |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 601 |
| Chain | Residue |
| A | SER114 |
| A | HIS292 |
| A | LLP318 |
| A | ARG454 |
| B | TYR144 |
| B | HOH707 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue FMT B 601 |
| Chain | Residue |
| B | THR316 |
| B | HIS317 |
| B | LLP318 |
| B | SER319 |
| B | LEU320 |
| B | HOH701 |
| B | ALA291 |
| B | SER294 |
| B | THR315 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 602 |
| Chain | Residue |
| A | TYR144 |
| A | HOH705 |
| B | SER114 |
| B | SER264 |
| B | HIS292 |
| B | LLP318 |
| B | ARG454 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue FMT C 601 |
| Chain | Residue |
| C | ALA291 |
| C | SER294 |
| C | THR315 |
| C | THR316 |
| C | HIS317 |
| C | LYS318 |
| C | SER319 |
| C | LEU320 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 602 |
| Chain | Residue |
| C | SER180 |
| C | GLY181 |
| C | SER182 |
| C | HOH1012 |
| D | GLY354 |
| D | FMT601 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue FMT D 601 |
| Chain | Residue |
| C | SER180 |
| C | ACT602 |
| D | LEU179 |
| D | GLN353 |
| D | GLY354 |
| D | GLY355 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue FMT D 602 |
| Chain | Residue |
| D | ALA291 |
| D | SER294 |
| D | THR315 |
| D | THR316 |
| D | HIS317 |
| D | LLP318 |
| D | SER319 |
| D | LEU320 |
| D | HOH701 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DIvTTTTHKSLrGPRGG |
| Chain | Residue | Details |
| C | ASP310-GLY326 | |
| A | ASP310-GLY326 |
