Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CAA

CryoEM structure of human SLC4A4 sodium-coupled acid-base transporter NBCe1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005452	molecular_function	solute:inorganic anion antiporter activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006820	biological_process	monoatomic anion transport
A	0008509	molecular_function	monoatomic anion transmembrane transporter activity
A	0008510	molecular_function	sodium:bicarbonate symporter activity
A	0009986	cellular_component	cell surface
A	0015293	molecular_function	symporter activity
A	0015698	biological_process	inorganic anion transport
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0036376	biological_process	sodium ion export across plasma membrane
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0045821	biological_process	positive regulation of glycolytic process
A	0051453	biological_process	regulation of intracellular pH
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0150104	biological_process	transport across blood-brain barrier
B	0005452	molecular_function	solute:inorganic anion antiporter activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006820	biological_process	monoatomic anion transport
B	0008509	molecular_function	monoatomic anion transmembrane transporter activity
B	0008510	molecular_function	sodium:bicarbonate symporter activity
B	0009986	cellular_component	cell surface
B	0015293	molecular_function	symporter activity
B	0015698	biological_process	inorganic anion transport
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0036376	biological_process	sodium ion export across plasma membrane
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0045821	biological_process	positive regulation of glycolytic process
B	0051453	biological_process	regulation of intracellular pH
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0098656	biological_process	monoatomic anion transmembrane transport
B	0150104	biological_process	transport across blood-brain barrier

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	78
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=3","evidences":[{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	34
Details	Transmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	82
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"12534288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	50
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"29500354","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Region: {"description":"CA2-binding"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GalNAc) asparagine","evidences":[{"source":"PubMed","id":"25568315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)