6CAA
CryoEM structure of human SLC4A4 sodium-coupled acid-base transporter NBCe1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006820 | biological_process | monoatomic anion transport |
| A | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| A | 0008510 | molecular_function | sodium:bicarbonate symporter activity |
| A | 0009986 | cellular_component | cell surface |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015698 | biological_process | inorganic anion transport |
| A | 0015701 | biological_process | bicarbonate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0036376 | biological_process | sodium ion export across plasma membrane |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045821 | biological_process | positive regulation of glycolytic process |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| B | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006820 | biological_process | monoatomic anion transport |
| B | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| B | 0008510 | molecular_function | sodium:bicarbonate symporter activity |
| B | 0009986 | cellular_component | cell surface |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015698 | biological_process | inorganic anion transport |
| B | 0015701 | biological_process | bicarbonate transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0036376 | biological_process | sodium ion export across plasma membrane |
| B | 0042391 | biological_process | regulation of membrane potential |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045821 | biological_process | positive regulation of glycolytic process |
| B | 0051453 | biological_process | regulation of intracellular pH |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098656 | biological_process | monoatomic anion transmembrane transport |
| B | 0150104 | biological_process | transport across blood-brain barrier |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1238 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | MET1-VAL466 | |
| A | LYS812-ARG833 | |
| A | GLY875-CYS916 | |
| A | ARG943-CYS1035 | |
| B | MET1-VAL466 | |
| B | LYS812-ARG833 | |
| B | GLY875-CYS916 | |
| B | ARG943-CYS1035 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | ILE423-LEU447 | |
| B | ILE423-LEU447 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 98 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | GLY448-VAL457 | |
| A | VAL702-TRP735 | |
| A | ALA793 | |
| A | PRO851-PRO857 | |
| B | GLY448-VAL457 | |
| B | VAL702-TRP735 | |
| B | ALA793 | |
| B | PRO851-PRO857 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | LEU458-GLY476 | |
| B | LEU458-GLY476 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 78 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | GLN477 | |
| A | ASP528-GLU541 | |
| A | LYS667-LYS681 | |
| A | ARG764-TYR775 | |
| B | GLN477 | |
| B | ASP528-GLU541 | |
| B | LYS667-LYS681 | |
| B | ARG764-TYR775 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Discontinuously helical; Name=3 => ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | PRO478-PHE498 | |
| B | PRO478-PHE498 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 178 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | SER499-TYR506 | |
| A | TYR566-ILE648 | |
| B | SER499-TYR506 | |
| B | TYR566-ILE648 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | LEU507-THR527 | |
| B | LEU507-THR527 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | GLU542-ASP565 | |
| B | GLU542-ASP565 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | THR649-LEU666 | |
| B | THR649-LEU666 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | LEU682-LEU701 | |
| B | LEU682-LEU701 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | VAL736-ASN763 | |
| B | VAL736-ASN763 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | HIS776-MET792 | |
| B | HIS776-MET792 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 34 |
| Details | TRANSMEM: Discontinuously helical; Name=10 => ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | LEU794-LEU811 | |
| B | LEU794-LEU811 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | VAL834-ALA850 | |
| B | VAL834-ALA850 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | MET858-ASN874 | |
| B | MET858-ASN874 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 50 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000305|PubMed:29500354 |
| Chain | Residue | Details |
| A | LEU917-VAL942 | |
| B | LEU917-VAL942 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O88343 |
| Chain | Residue | Details |
| A | PRO30 | |
| B | PRO30 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKA => ECO:0000269|PubMed:12730338 |
| Chain | Residue | Details |
| A | ARG49 | |
| B | ARG49 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 22 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88343 |
| Chain | Residue | Details |
| A | PRO61 | |
| A | SER985 | |
| A | SER1000 | |
| B | PRO61 | |
| B | PHE65 | |
| B | LEU68 | |
| B | SER179 | |
| B | SER188 | |
| B | SER189 | |
| B | SER201 | |
| B | SER212 | |
| A | PHE65 | |
| B | SER218 | |
| B | SER985 | |
| B | SER1000 | |
| A | LEU68 | |
| A | SER179 | |
| A | SER188 | |
| A | SER189 | |
| A | SER201 | |
| A | SER212 | |
| A | SER218 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9JI66 |
| Chain | Residue | Details |
| A | THR205 | |
| B | THR205 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR210 | |
| B | THR210 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER213 | |
| A | SER990 | |
| B | SER213 | |
| B | SER990 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338 |
| Chain | Residue | Details |
| A | SER982 | |
| B | SER982 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JI66 |
| Chain | Residue | Details |
| A | SER1025 | |
| B | SER1025 |
