6C9U
Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue K A 1001 |
| Chain | Residue |
| A | ASP300 |
| A | SER303 |
| A | LEU306 |
| A | ALA308 |
| A | HOH1286 |
| A | HOH1495 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 1002 |
| Chain | Residue |
| A | GLY848 |
| A | GLU850 |
| A | VAL843 |
| A | GLU844 |
| A | ALA846 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 1003 |
| Chain | Residue |
| A | ALA543 |
| A | ALA545 |
| A | VAL548 |
| A | HOH1287 |
| A | HOH1377 |
| A | HOH1489 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR201-HIS207 | |
| L | TYR214-HIS220 |
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSisVDtACSSSlvAL |
| Chain | Residue | Details |
| A | GLY194-LEU210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-thioester intermediate; for beta-ketoacyl synthase 1 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17719492","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For beta-ketoacyl synthase 1 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate; for acyltransferase 1 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU10022","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for substrate specificity of the beta-ketoacyl synthase 1","evidences":[{"source":"PubMed","id":"17719492","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
