Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6C98

Crystal structure of FcRn bound to UCB-84

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002715biological_processregulation of natural killer cell mediated immunity
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032398cellular_componentMHC class Ib protein complex
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071316biological_processcellular response to nicotine
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
D0000139cellular_componentGolgi membrane
D0002376biological_processimmune system process
D0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
D0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
D0002502biological_processpeptide antigen assembly with MHC class I protein complex
D0002503biological_processpeptide antigen assembly with MHC class II protein complex
D0002715biological_processregulation of natural killer cell mediated immunity
D0002726biological_processpositive regulation of T cell cytokine production
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005765cellular_componentlysosomal membrane
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006879biological_processintracellular iron ion homeostasis
D0006955biological_processimmune response
D0007608biological_processsensory perception of smell
D0007611biological_processlearning or memory
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010038biological_processresponse to metal ion
D0012507cellular_componentER to Golgi transport vesicle membrane
D0016020cellular_componentmembrane
D0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0023026molecular_functionMHC class II protein complex binding
D0030670cellular_componentphagocytic vesicle membrane
D0031901cellular_componentearly endosome membrane
D0031902cellular_componentlate endosome membrane
D0031905cellular_componentearly endosome lumen
D0032398cellular_componentMHC class Ib protein complex
D0033572biological_processtransferrin transport
D0034756biological_processregulation of iron ion transport
D0034757biological_processnegative regulation of iron ion transport
D0035580cellular_componentspecific granule lumen
D0042605molecular_functionpeptide antigen binding
D0042612cellular_componentMHC class I protein complex
D0042613cellular_componentMHC class II protein complex
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042824cellular_componentMHC class I peptide loading complex
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050768biological_processnegative regulation of neurogenesis
D0050778biological_processpositive regulation of immune response
D0050870biological_processpositive regulation of T cell activation
D0051289biological_processprotein homotetramerization
D0055038cellular_componentrecycling endosome membrane
D0070062cellular_componentextracellular exosome
D0071281biological_processcellular response to iron ion
D0071316biological_processcellular response to nicotine
D1904724cellular_componenttertiary granule lumen
D1990000biological_processamyloid fibril formation
D1990712cellular_componentHFE-transferrin receptor complex
D2000774biological_processpositive regulation of cellular senescence
D2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue CYS A 301
ChainResidue
ASER37
APRO47
ACYS48
AHOH411
AHOH425
BASP53
BHOH225
site_idAC2
Number of Residues12
Detailsbinding site for residue ER7 B 101
ChainResidue
AGLN34
ASER230
AHOH435
BTYR26
BSER52
BASP53
BTYR63
BLEU64
BLEU65
BHOH274
ATRP29
APRO32
site_idAC3
Number of Residues8
Detailsbinding site for residue GOL B 102
ChainResidue
BILE7
BGLN8
BVAL9
BVAL93
BLYS94
BASP96
BMET99
BHOH232
site_idAC4
Number of Residues5
Detailsbinding site for residue PEG B 103
ChainResidue
BARG12
BHIS13
BHOH205
DARG12
DHIS13
site_idAC5
Number of Residues6
Detailsbinding site for residue CYS C 301
ChainResidue
CSER37
CPRO47
CCYS48
CHOH442
DASP53
DHOH216
site_idAC6
Number of Residues13
Detailsbinding site for residue ER7 D 101
ChainResidue
CTRP29
CPRO32
CGLN34
CSER230
CGLY232
CHOH420
DTYR26
DSER52
DASP53
DTYR63
DLEU64
DLEU65
DHOH268
site_idAC7
Number of Residues7
Detailsbinding site for residue GOL D 102
ChainResidue
DGLN8
DVAL9
DVAL93
DLYS94
DASP96
DMET99
DHOH218
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH
ChainResidueDetails
ATYR250-HIS256
BTYR78-HIS84
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues174
DetailsDomain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues178
DetailsRegion: {"description":"Alpha-2","evidences":[{"source":"PubMed","id":"10933786","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues178
DetailsRegion: {"description":"Alpha-3","evidences":[{"source":"PubMed","id":"10933786","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues176
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

PDB statisticsPDBj update infoContact PDBjnumon