6C86
Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue KAA A 601 |
| Chain | Residue |
| A | GLY249 |
| A | PHE307 |
| A | GLU311 |
| A | TYR313 |
| A | GLU464 |
| A | LEU465 |
| A | CYS466 |
| A | ASN467 |
| A | TYR469 |
| A | GLU471 |
| A | GLY516 |
| A | ALA250 |
| A | TRP517 |
| A | GLY518 |
| A | GLY520 |
| A | ARG523 |
| A | HOH721 |
| A | HOH810 |
| A | HOH924 |
| A | HOH929 |
| A | ALA271 |
| A | GLU273 |
| A | ARG295 |
| A | GLU297 |
| A | THR302 |
| A | HIS303 |
| A | ASN304 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | ASN85 |
| A | TRP445 |
| A | HIS446 |
| A | ARG447 |
| A | GLU448 |
| A | PRO450 |
| A | HOH789 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 603 |
| Chain | Residue |
| A | THR361 |
| A | HOH785 |
| A | HOH1025 |
| B | HOH815 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | ARG253 |
| A | ARG253 |
| A | HOH701 |
| A | HOH701 |
| B | ASN260 |
| B | ASN260 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | binding site for residue KAA B 601 |
| Chain | Residue |
| B | GLY249 |
| B | ALA271 |
| B | GLU273 |
| B | ARG295 |
| B | GLU297 |
| B | THR302 |
| B | HIS303 |
| B | ASN304 |
| B | PHE307 |
| B | GLU311 |
| B | TYR313 |
| B | GLU464 |
| B | LEU465 |
| B | ASN467 |
| B | TYR469 |
| B | GLU471 |
| B | GLY516 |
| B | TRP517 |
| B | GLY518 |
| B | GLY520 |
| B | ARG523 |
| B | HOH746 |
| B | HOH749 |
| B | HOH933 |
| B | HOH964 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| A | ARG227 |
| A | ILE290 |
| B | ARG227 |
| B | GLU237 |
| B | EDO603 |
| B | HOH945 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| A | ARG227 |
| A | GLU237 |
| A | HOH876 |
| B | ARG227 |
| B | ILE290 |
| B | EDO602 |
| B | HOH928 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 604 |
| Chain | Residue |
| B | SER386 |
| B | GLN387 |
| B | GLU388 |
| B | HOH800 |
| B | HOH815 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| B | HIS446 |
| B | ARG447 |
| B | GLU448 |
| B | LYS449 |
| B | PRO450 |
| B | HOH878 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 606 |
| Chain | Residue |
| A | LYS59 |
| B | TRP445 |
| B | GLN477 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 607 |
| Chain | Residue |
| B | CYS354 |
