6C7N
Monoclinic form of malic enzyme from sorghum at 2 angstroms resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004470 | molecular_function | malic enzyme activity |
| A | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0009507 | cellular_component | chloroplast |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004470 | molecular_function | malic enzyme activity |
| B | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0009507 | cellular_component | chloroplast |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004470 | molecular_function | malic enzyme activity |
| C | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0006108 | biological_process | malate metabolic process |
| C | 0009507 | cellular_component | chloroplast |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004470 | molecular_function | malic enzyme activity |
| D | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0006108 | biological_process | malate metabolic process |
| D | 0009507 | cellular_component | chloroplast |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 40 |
| Details | binding site for residue NAP A 1001 |
| Chain | Residue |
| A | ASN331 |
| A | SER419 |
| A | LYS435 |
| A | THR463 |
| A | SER464 |
| A | GLY465 |
| A | VAL466 |
| A | LEU490 |
| A | SER491 |
| A | ASN492 |
| A | GLY517 |
| A | THR355 |
| A | SER535 |
| A | ASN537 |
| A | GOL1007 |
| A | HOH1108 |
| A | HOH1116 |
| A | HOH1127 |
| A | HOH1136 |
| A | HOH1140 |
| A | HOH1161 |
| A | HOH1177 |
| A | LEU382 |
| A | HOH1204 |
| A | HOH1236 |
| A | HOH1237 |
| A | HOH1249 |
| A | HOH1257 |
| A | HOH1337 |
| A | HOH1346 |
| A | HOH1391 |
| A | HOH1409 |
| A | HOH1431 |
| A | GLY383 |
| A | HOH1449 |
| A | ALA384 |
| A | GLY385 |
| A | GLU386 |
| A | ALA387 |
| A | ASP418 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1002 |
| Chain | Residue |
| A | ARG299 |
| A | GLY300 |
| A | TYR303 |
| A | ASP304 |
| A | ASN333 |
| A | HOH1112 |
| A | HOH1138 |
| A | HOH1406 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1003 |
| Chain | Residue |
| A | TRP222 |
| A | LEU256 |
| A | PRO267 |
| A | CYS270 |
| A | PRO272 |
| A | HOH1121 |
| A | HOH1123 |
| A | HOH1141 |
| A | HOH1432 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1004 |
| Chain | Residue |
| A | ASN331 |
| A | PHE335 |
| A | GLU386 |
| A | HOH1116 |
| A | HOH1119 |
| A | HOH1209 |
| A | HOH1220 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1005 |
| Chain | Residue |
| A | ARG102 |
| A | HOH1210 |
| A | HOH1213 |
| B | ASP103 |
| B | HOH1185 |
| D | ALA91 |
| D | THR92 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1006 |
| Chain | Residue |
| A | TYR98 |
| A | ARG102 |
| A | HOH1130 |
| A | HOH1188 |
| B | GLU162 |
| B | PRO202 |
| B | HIS224 |
| B | GOL1006 |
| B | HOH1270 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1007 |
| Chain | Residue |
| A | ASP418 |
| A | SER419 |
| A | THR446 |
| A | NAP1001 |
| A | HOH1268 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1008 |
| Chain | Residue |
| A | GLN228 |
| A | GLY264 |
| A | VAL265 |
| A | ASP266 |
| A | CYS626 |
| A | TYR628 |
| A | HOH1226 |
| site_id | AC9 |
| Number of Residues | 40 |
| Details | binding site for residue NAP B 1001 |
| Chain | Residue |
| B | ALA384 |
| B | GLY385 |
| B | GLU386 |
| B | ALA387 |
| B | ASP418 |
| B | SER419 |
| B | LYS435 |
| B | THR463 |
| B | SER464 |
| B | GLY465 |
| B | VAL466 |
| B | LEU490 |
| B | SER491 |
| B | ASN492 |
| B | GLY517 |
| B | SER535 |
| B | ASN537 |
| B | PYR1002 |
| B | PEG1009 |
| B | HOH1142 |
| B | HOH1149 |
| B | HOH1158 |
| B | HOH1177 |
| B | HOH1229 |
| B | HOH1274 |
| B | HOH1279 |
| B | HOH1301 |
| B | HOH1313 |
| B | HOH1347 |
| B | HOH1374 |
| B | HOH1458 |
| B | HOH1497 |
| B | HOH1507 |
| B | ARG237 |
| B | LEU239 |
| B | GLY240 |
| B | ASN331 |
| B | THR355 |
| B | LEU382 |
| B | GLY383 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue PYR B 1002 |
| Chain | Residue |
| B | TYR184 |
| B | ARG237 |
| B | LEU239 |
| B | LYS255 |
| B | ASP351 |
| B | ASN492 |
| B | NAP1001 |
| B | HOH1143 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue PYR B 1003 |
| Chain | Residue |
| A | TYR147 |
| A | MET155 |
| A | ALA156 |
| A | HOH1421 |
| B | TYR147 |
| B | ALA156 |
| B | ASN159 |
| B | HOH1329 |
| B | HOH1429 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1004 |
| Chain | Residue |
| B | ARG299 |
| B | GLY300 |
| B | TYR303 |
| B | ASP304 |
| B | HOH1109 |
| B | HOH1208 |
| B | HOH1217 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1005 |
| Chain | Residue |
| A | ASP103 |
| A | HOH1131 |
| B | ARG102 |
| B | HOH1293 |
| B | HOH1324 |
| C | ALA91 |
| C | THR92 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 1006 |
| Chain | Residue |
| A | GOL1006 |
| B | LEU256 |
| B | PRO267 |
| B | CYS270 |
| B | HOH1160 |
| B | HOH1190 |
| B | HOH1241 |
| B | HOH1378 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 1007 |
| Chain | Residue |
| B | GLN228 |
| B | GLY264 |
| B | VAL265 |
| B | ASP266 |
| B | CYS626 |
| B | TYR628 |
| B | HOH1189 |
| B | HOH1245 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1008 |
| Chain | Residue |
| B | VAL466 |
| B | GLY467 |
| B | ARG468 |
| B | SER495 |
| B | HIS496 |
| B | HOH1230 |
| B | HOH1355 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue PEG B 1009 |
| Chain | Residue |
| B | LEU382 |
| B | VAL417 |
| B | ASP418 |
| B | SER419 |
| B | LYS420 |
| B | GLY421 |
| B | THR446 |
| B | THR447 |
| B | LEU448 |
| B | NAP1001 |
| site_id | AD9 |
| Number of Residues | 32 |
| Details | binding site for residue NAP C 1001 |
| Chain | Residue |
| C | ARG237 |
| C | LEU239 |
| C | GLY240 |
| C | ASN331 |
| C | THR355 |
| C | LEU382 |
| C | GLY383 |
| C | ALA384 |
| C | GLY385 |
| C | GLU386 |
| C | ALA387 |
| C | GLY388 |
| C | VAL417 |
| C | ASP418 |
| C | SER419 |
| C | LYS420 |
| C | GLY421 |
| C | LYS435 |
| C | LEU448 |
| C | GLY462 |
| C | THR463 |
| C | SER464 |
| C | GLY465 |
| C | VAL466 |
| C | LEU490 |
| C | SER491 |
| C | ASN492 |
| C | GLU498 |
| C | GLY517 |
| C | SER535 |
| C | ASN537 |
| C | HOH1177 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue PYR C 1002 |
| Chain | Residue |
| C | MET155 |
| C | ALA156 |
| C | HOH1229 |
| C | HOH1238 |
| C | HOH1266 |
| D | TYR147 |
| D | ALA156 |
| D | HOH1251 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 1003 |
| Chain | Residue |
| C | ARG299 |
| C | GLY300 |
| C | TYR303 |
| C | ASP304 |
| C | HOH1105 |
| C | HOH1171 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 1004 |
| Chain | Residue |
| C | TRP222 |
| C | LEU256 |
| C | PRO267 |
| C | CYS270 |
| C | HOH1102 |
| C | HOH1130 |
| C | HOH1136 |
| C | HOH1199 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue NAP D 1001 |
| Chain | Residue |
| D | ARG237 |
| D | ASN331 |
| D | THR355 |
| D | ALA384 |
| D | GLY385 |
| D | GLU386 |
| D | ALA387 |
| D | GLY388 |
| D | SER535 |
| D | ASN537 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 1002 |
| Chain | Residue |
| D | ARG299 |
| D | GLY300 |
| D | TYR303 |
| D | ASP304 |
| D | ASN333 |
| D | HOH1124 |
| D | HOH1135 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 1003 |
| Chain | Residue |
| D | GLU165 |
| D | HIS224 |
| D | LEU256 |
| D | PRO267 |
| D | CYS270 |
| D | HOH1103 |
| D | HOH1121 |
| D | HOH1177 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 1004 |
| Chain | Residue |
| D | GLN228 |
| D | ASP266 |
| D | CYS626 |
Functional Information from PROSITE/UniProt
| site_id | PS00331 |
| Number of Residues | 17 |
| Details | MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVvLAGLL |
| Chain | Residue | Details |
| A | PHE348-LEU364 |
