6C7E
Crystal structure of human phosphodiesterase 2A with 1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue EOG A 1001 |
| Chain | Residue |
| A | LEU770 |
| A | HOH1167 |
| A | HOH1225 |
| A | HOH1276 |
| A | LEU809 |
| A | GLN812 |
| A | ILE826 |
| A | PHE830 |
| A | MET847 |
| A | GLN859 |
| A | PHE862 |
| A | HOH1156 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | HIS660 |
| A | HIS696 |
| A | ASP697 |
| A | ASP808 |
| A | HOH1135 |
| A | HOH1260 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1003 |
| Chain | Residue |
| A | ASP697 |
| A | HOH1128 |
| A | HOH1135 |
| A | HOH1180 |
| A | HOH1205 |
| A | HOH1280 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue EOG B 1001 |
| Chain | Residue |
| B | LEU770 |
| B | LEU809 |
| B | GLN812 |
| B | ILE826 |
| B | PHE830 |
| B | PHE862 |
| B | HOH1134 |
| B | HOH1146 |
| B | HOH1147 |
| B | HOH1216 |
| B | HOH1275 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1002 |
| Chain | Residue |
| B | HIS660 |
| B | HIS696 |
| B | ASP697 |
| B | ASP808 |
| B | HOH1118 |
| B | HOH1268 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1003 |
| Chain | Residue |
| B | ASP697 |
| B | HOH1118 |
| B | HOH1127 |
| B | HOH1151 |
| B | HOH1165 |
| B | HOH1267 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue EOG C 1001 |
| Chain | Residue |
| C | LEU770 |
| C | LEU809 |
| C | GLN812 |
| C | ILE826 |
| C | PHE830 |
| C | PHE862 |
| C | HOH1104 |
| C | HOH1160 |
| C | HOH1165 |
| C | HOH1239 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 1002 |
| Chain | Residue |
| C | HIS660 |
| C | HIS696 |
| C | ASP697 |
| C | ASP808 |
| C | HOH1107 |
| C | HOH1226 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 1003 |
| Chain | Residue |
| C | ASP697 |
| C | HOH1107 |
| C | HOH1134 |
| C | HOH1142 |
| C | HOH1164 |
| C | HOH1246 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue EOG D 1001 |
| Chain | Residue |
| D | LEU770 |
| D | GLN812 |
| D | ILE826 |
| D | PHE830 |
| D | PHE862 |
| D | HOH1137 |
| D | HOH1161 |
| D | HOH1182 |
| D | HOH1248 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 1002 |
| Chain | Residue |
| D | HIS660 |
| D | HIS696 |
| D | ASP697 |
| D | ASP808 |
| D | HOH1116 |
| D | HOH1227 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 1003 |
| Chain | Residue |
| D | ASP697 |
| D | HOH1116 |
| D | HOH1127 |
| D | HOH1195 |
| D | HOH1219 |
| D | HOH1272 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF |
| Chain | Residue | Details |
| A | HIS696-PHE707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
