6C6K
Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004857 | molecular_function | enzyme inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009615 | biological_process | response to virus |
| A | 0019060 | biological_process | intracellular transport of viral protein in host cell |
| A | 0043657 | cellular_component | host cell |
| A | 0045070 | biological_process | positive regulation of viral genome replication |
| A | 0045071 | biological_process | negative regulation of viral genome replication |
| A | 0045087 | biological_process | innate immune response |
| A | 0051607 | biological_process | defense response to virus |
| A | 0051707 | biological_process | response to other organism |
| A | 0071345 | biological_process | cellular response to cytokine stimulus |
| A | 0071357 | biological_process | cellular response to type I interferon |
| A | 0071360 | biological_process | cellular response to exogenous dsRNA |
| A | 0140374 | biological_process | antiviral innate immune response |
| A | 0140610 | molecular_function | RNA sequestering activity |
| A | 1904972 | biological_process | negative regulation of viral translation |
| B | 0002376 | biological_process | immune system process |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004857 | molecular_function | enzyme inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009615 | biological_process | response to virus |
| B | 0019060 | biological_process | intracellular transport of viral protein in host cell |
| B | 0043657 | cellular_component | host cell |
| B | 0045070 | biological_process | positive regulation of viral genome replication |
| B | 0045071 | biological_process | negative regulation of viral genome replication |
| B | 0045087 | biological_process | innate immune response |
| B | 0051607 | biological_process | defense response to virus |
| B | 0051707 | biological_process | response to other organism |
| B | 0071345 | biological_process | cellular response to cytokine stimulus |
| B | 0071357 | biological_process | cellular response to type I interferon |
| B | 0071360 | biological_process | cellular response to exogenous dsRNA |
| B | 0140374 | biological_process | antiviral innate immune response |
| B | 0140610 | molecular_function | RNA sequestering activity |
| B | 1904972 | biological_process | negative regulation of viral translation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| B | LEU152 |
| B | LYS153 |
| B | GLY155 |
| B | TYR159 |
| F | M7G1 |
| F | A2 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG E 101 |
| Chain | Residue |
| A | LYS338 |
| E | A2 |
| E | U3 |
| A | ASP36 |
| A | ARG40 |
| A | VAL287 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 102 |
| Chain | Residue |
| A | VAL343 |
| A | ASP347 |
| E | A4 |
| E | G5 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 103 |
| Chain | Residue |
| A | ARG264 |
| E | A4 |
| E | G5 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 62 |
| Details | Repeat: {"description":"TPR 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"TPR 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"TPR 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"TPR 9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28251928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UDL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
