6C6K

Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009615	biological_process	response to virus
A	0019060	biological_process	intracellular transport of viral protein in host cell
A	0032091	biological_process	negative regulation of protein binding
A	0043657	cellular_component	host cell
A	0045070	biological_process	positive regulation of viral genome replication
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0051097	biological_process	negative regulation of helicase activity
A	0051607	biological_process	defense response to virus
A	0051707	biological_process	response to other organism
A	0071357	biological_process	cellular response to type I interferon
A	0071360	biological_process	cellular response to exogenous dsRNA
A	0140374	biological_process	antiviral innate immune response
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009615	biological_process	response to virus
B	0019060	biological_process	intracellular transport of viral protein in host cell
B	0032091	biological_process	negative regulation of protein binding
B	0043657	cellular_component	host cell
B	0045070	biological_process	positive regulation of viral genome replication
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0051097	biological_process	negative regulation of helicase activity
B	0051607	biological_process	defense response to virus
B	0051707	biological_process	response to other organism
B	0071357	biological_process	cellular response to type I interferon
B	0071360	biological_process	cellular response to exogenous dsRNA
B	0140374	biological_process	antiviral innate immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG B 501

Chain	Residue
B	LEU152
B	LYS153
B	GLY155
B	TYR159
F	M7G1
F	A2

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site_id	AC2
Number of Residues	6
Details	binding site for residue MG E 101

Chain	Residue
A	LYS338
E	A2
E	U3
A	ASP36
A	ARG40
A	VAL287

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site_id	AC3
Number of Residues	4
Details	binding site for residue MG E 102

Chain	Residue
A	VAL343
A	ASP347
E	A4
E	G5

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site_id	AC4
Number of Residues	3
Details	binding site for residue MG E 103

Chain	Residue
A	ARG264
E	A4
E	G5

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	SITE: Interaction with PPP-RNA => ECO:0000250

Chain	Residue	Details
A	ASP36
B	TYR254
A	GLN44
A	LYS153
A	ARG189
A	TYR254
B	ASP36
B	GLN44
B	LYS153
B	ARG189

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Interaction with the 5'-triphosphate group of PPP-RNA => ECO:0000250

Chain	Residue	Details
A	GLN292
B	GLN292

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