6C2O
Crystal structure of HCV NS3/4A protease variant Y56H in complex with danoprevir
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | transformation of host cell by virus |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue TSV A 1201 |
| Chain | Residue |
| A | HIS982 |
| A | LEU1135 |
| A | LYS1136 |
| A | GLY1137 |
| A | SER1138 |
| A | SER1139 |
| A | PHE1154 |
| A | ARG1155 |
| A | ALA1156 |
| A | ALA1157 |
| A | ASP1168 |
| A | GLN1041 |
| A | HOH1338 |
| A | HOH1340 |
| A | HOH1370 |
| A | HOH1391 |
| A | HOH1419 |
| A | HOH1423 |
| A | PHE1043 |
| A | HIS1057 |
| A | GLY1058 |
| A | VAL1078 |
| A | ASP1079 |
| A | ASP1081 |
| A | ARG1123 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1202 |
| Chain | Residue |
| A | CYS1097 |
| A | CYS1099 |
| A | CYS1145 |
| A | HIS1149 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 1203 |
| Chain | Residue |
| A | ASN1049 |
| A | ASP1121 |
| A | SER1122 |
