6C2O

Crystal structure of HCV NS3/4A protease variant Y56H in complex with danoprevir

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003724	molecular_function	RNA helicase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	symbiont-mediated transformation of host cell
A	0033644	cellular_component	host cell membrane
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
A	0043657	cellular_component	host cell
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0055036	cellular_component	virion membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue TSV A 1201

Chain	Residue
A	HIS982
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	ASP1168
A	GLN1041
A	HOH1338
A	HOH1340
A	HOH1370
A	HOH1391
A	HOH1419
A	HOH1423
A	PHE1043
A	HIS1057
A	GLY1058
A	VAL1078
A	ASP1079
A	ASP1081
A	ARG1123

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1202

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

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site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 1203

Chain	Residue
A	ASN1049
A	ASP1121
A	SER1122

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