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6C2O

Crystal structure of HCV NS3/4A protease variant Y56H in complex with danoprevir

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0016020cellular_componentmembrane
A0019062biological_processvirion attachment to host cell
A0019087biological_processtransformation of host cell by virus
A0033644cellular_componenthost cell membrane
A0044423cellular_componentvirion component
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue TSV A 1201
ChainResidue
AHIS982
ALEU1135
ALYS1136
AGLY1137
ASER1138
ASER1139
APHE1154
AARG1155
AALA1156
AALA1157
AASP1168
AGLN1041
AHOH1338
AHOH1340
AHOH1370
AHOH1391
AHOH1419
AHOH1423
APHE1043
AHIS1057
AGLY1058
AVAL1078
AASP1079
AASP1081
AARG1123

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 1202
ChainResidue
ACYS1097
ACYS1099
ACYS1145
AHIS1149

site_idAC3
Number of Residues3
Detailsbinding site for residue GOL A 1203
ChainResidue
AASN1049
AASP1121
ASER1122

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PDB entries from 2024-09-18

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