6C1K
HypoPP mutant with ligand1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GAI A 1301 |
| Chain | Residue |
| A | GLU1032 |
| A | ARG1099 |
| A | ARG1105 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PX4 A 1302 |
| Chain | Residue |
| A | SER1034 |
| A | THR1036 |
| A | PHE1037 |
| A | PX41307 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue PX4 A 1303 |
| Chain | Residue |
| A | THR1162 |
| A | LEU1163 |
| A | GLY1164 |
| A | PX41304 |
| B | GLY2026 |
| B | ILE2027 |
| B | GLY2030 |
| B | LEU2031 |
| B | SER2034 |
| B | PX42301 |
| A | THR1138 |
| A | TYR1142 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PX4 A 1304 |
| Chain | Residue |
| A | SER1132 |
| A | PX41303 |
| B | VAL2023 |
| B | MET2116 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 A 1305 |
| Chain | Residue |
| A | PRO1075 |
| A | TRP1076 |
| A | PHE1107 |
| A | SER1121 |
| A | ILE1124 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue PX4 A 1306 |
| Chain | Residue |
| A | PHE1082 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue PX4 A 1307 |
| Chain | Residue |
| A | ILE1027 |
| A | GLY1030 |
| A | SER1034 |
| A | LYS1035 |
| A | THR1036 |
| A | PX41302 |
| B | THR2138 |
| B | TYR2142 |
| B | THR2162 |
| B | LEU2163 |
| B | GLY2164 |
| B | PX42306 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PX4 A 1308 |
| Chain | Residue |
| A | PHE1095 |
| B | TYR2193 |
| B | PX42307 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue PX4 A 1309 |
| Chain | Residue |
| A | GLN1115 |
| A | MET1116 |
| B | SER2132 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 A 1310 |
| Chain | Residue |
| A | MET1174 |
| B | PHE2203 |
| B | THR2206 |
| B | PHE2207 |
| B | PX42301 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 1311 |
| Chain | Residue |
| A | GLY1182 |
| B | MET2181 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 1312 |
| Chain | Residue |
| A | GLU1158 |
| A | TRP1159 |
| B | MET2181 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1313 |
| Chain | Residue |
| A | PHE1156 |
| A | PRO1157 |
| A | GLU1158 |
| A | TRP1159 |
| B | SO42312 |
| site_id | AD5 |
| Number of Residues | 15 |
| Details | binding site for residue PX4 B 2301 |
| Chain | Residue |
| A | MET1137 |
| A | PHE1141 |
| A | THR1162 |
| A | GLY1164 |
| A | GLU1165 |
| A | PHE1167 |
| A | TYR1168 |
| A | PHE1171 |
| A | MET1209 |
| A | PX41303 |
| A | PX41310 |
| B | MET2188 |
| B | PRO2192 |
| B | TRP2195 |
| B | PHE2203 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue PX4 B 2302 |
| Chain | Residue |
| A | LEU1151 |
| A | ARG1155 |
| A | VAL1190 |
| A | TYR1191 |
| A | TYR1193 |
| B | ILE2097 |
| B | PX42303 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue PX4 B 2303 |
| Chain | Residue |
| A | TYR1193 |
| B | PHE2095 |
| B | PX42302 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue PX4 B 2304 |
| Chain | Residue |
| A | THR1206 |
| A | PHE1207 |
| B | MET2174 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GAI B 2305 |
| Chain | Residue |
| B | MET2029 |
| B | GLU2032 |
| B | ARG2099 |
| B | ARG2105 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue PX4 B 2306 |
| Chain | Residue |
| B | GLY2164 |
| B | GLU2165 |
| B | TYR2168 |
| B | MET2209 |
| A | PRO1192 |
| A | TRP1195 |
| A | PX41307 |
| B | MET2137 |
| B | THR2162 |
| site_id | AE2 |
| Number of Residues | 11 |
| Details | binding site for residue PX4 B 2307 |
| Chain | Residue |
| A | ILE1097 |
| A | PX41308 |
| B | PHE2144 |
| B | LEU2151 |
| B | PHE2152 |
| B | ARG2155 |
| B | VAL2190 |
| B | TYR2193 |
| B | VAL2196 |
| B | PHE2197 |
| B | PRO2200 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 B 2308 |
| Chain | Residue |
| A | PHE1140 |
| B | TRP2076 |
| B | PHE2079 |
| B | PHE2107 |
| B | SER2121 |
| B | ILE2124 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue PX4 B 2309 |
| Chain | Residue |
| B | PHE2082 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 2310 |
| Chain | Residue |
| B | TRP2159 |
| B | GLY2182 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 2311 |
| Chain | Residue |
| A | MET1181 |
| B | GLU2158 |
| B | TRP2159 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 2312 |
| Chain | Residue |
| A | SO41313 |
| B | PHE2156 |
| B | PRO2157 |
| B | GLU2158 |
| B | TRP2159 |
