6C12
SDHA-SDHE complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000104 | molecular_function | succinate dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0019646 | biological_process | aerobic electron transport chain |
| A | 0022900 | biological_process | electron transport chain |
| A | 0045281 | cellular_component | succinate dehydrogenase complex |
| A | 0045282 | cellular_component | plasma membrane succinate dehydrogenase complex |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0000104 | molecular_function | succinate dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0009060 | biological_process | aerobic respiration |
| B | 0009061 | biological_process | anaerobic respiration |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0019646 | biological_process | aerobic electron transport chain |
| B | 0022900 | biological_process | electron transport chain |
| B | 0045281 | cellular_component | succinate dehydrogenase complex |
| B | 0045282 | cellular_component | plasma membrane succinate dehydrogenase complex |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006105 | biological_process | succinate metabolic process |
| C | 0034552 | biological_process | respiratory chain complex II assembly |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006105 | biological_process | succinate metabolic process |
| D | 0034552 | biological_process | respiratory chain complex II assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | binding site for residue FAD B 601 |
| Chain | Residue |
| B | GLY14 |
| B | HIS45 |
| B | THR46 |
| B | SER48 |
| B | ALA49 |
| B | GLN50 |
| B | TRP164 |
| B | TYR165 |
| B | ALA166 |
| B | ALA201 |
| B | THR202 |
| B | ALA15 |
| B | GLY203 |
| B | THR213 |
| B | ASN214 |
| B | ASP221 |
| B | HIS354 |
| B | TYR355 |
| B | GLY387 |
| B | GLU388 |
| B | GLY402 |
| B | SER404 |
| B | GLY16 |
| B | LEU405 |
| B | LEU408 |
| B | HOH726 |
| B | HOH734 |
| B | HOH736 |
| B | HOH753 |
| B | HOH763 |
| B | HOH840 |
| B | GLY17 |
| B | ALA18 |
| B | SER37 |
| B | LYS38 |
| B | VAL39 |
| B | SER44 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 602 |
| Chain | Residue |
| B | MET356 |
| B | MET357 |
| B | GLY358 |
| B | GLU388 |
| B | ALA390 |
| B | HOH715 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 602 |
| Chain | Residue |
| A | MET356 |
| A | MET357 |
| A | GLY358 |
| A | GLU388 |
| A | ALA390 |
| A | HOH711 |
| site_id | AC4 |
| Number of Residues | 39 |
| Details | binding site for Di-peptide FAD A 601 and HIS A 45 |
| Chain | Residue |
| A | GLY14 |
| A | ALA15 |
| A | GLY16 |
| A | GLY17 |
| A | ALA18 |
| A | SER37 |
| A | LYS38 |
| A | VAL39 |
| A | SER44 |
| A | THR46 |
| A | VAL47 |
| A | SER48 |
| A | ALA49 |
| A | GLN50 |
| A | GLY51 |
| A | TRP164 |
| A | TYR165 |
| A | ALA166 |
| A | ALA201 |
| A | THR202 |
| A | GLY203 |
| A | THR213 |
| A | ASN214 |
| A | ALA215 |
| A | ASP221 |
| A | HIS354 |
| A | TYR355 |
| A | GLY387 |
| A | GLU388 |
| A | GLY402 |
| A | SER404 |
| A | LEU405 |
| A | LEU408 |
| A | HOH730 |
| A | HOH749 |
| A | HOH765 |
| A | HOH810 |
| A | HOH825 |
| C | GLY16 |
Functional Information from PROSITE/UniProt
| site_id | PS00504 |
| Number of Residues | 10 |
| Details | FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvsAqGG |
| Chain | Residue | Details |
| B | ARG43-GLY52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:19710024 |
| Chain | Residue | Details |
| B | ARG286 | |
| A | ARG286 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 |
| Chain | Residue | Details |
| B | GLY14 | |
| A | SER404 | |
| B | SER37 | |
| B | ASP221 | |
| B | GLU388 | |
| B | SER404 | |
| A | GLY14 | |
| A | SER37 | |
| A | ASP221 | |
| A | GLU388 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19710024 |
| Chain | Residue | Details |
| B | HIS242 | |
| B | THR254 | |
| B | HIS354 | |
| B | ARG399 | |
| A | HIS242 | |
| A | THR254 | |
| A | HIS354 | |
| A | ARG399 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Tele-8alpha-FAD histidine => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 |
| Chain | Residue | Details |
| B | HIS45 | |
| A | HIS45 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| B | LYS267 | |
| A | LYS267 |
