Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue K5A A 601 |
| Chain | Residue |
| A | PRO95 |
| A | PHE227 |
| A | TRP229 |
| A | LEU234 |
| A | HIS235 |
| A | TYR318 |
| A | HOH849 |
| A | HOH936 |
| B | GLU138 |
| B | HOH680 |
| A | LEU100 |
| A | LYS101 |
| A | LYS103 |
| A | LYS104 |
| A | VAL106 |
| A | VAL179 |
| A | TYR181 |
| A | TYR188 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | ASP443 |
| A | ASP498 |
| A | ASP549 |
| A | HOH717 |
| A | HOH830 |
| A | HOH942 |
| A | HOH954 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | MET41 |
| A | LYS73 |
| A | TYR146 |
| A | PRO150 |
| A | GLN151 |
| A | HOH754 |
| A | HOH879 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | LYS331 |
| A | GLY333 |
| A | GLN334 |
| A | LYS512 |
| A | HOH857 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | SER515 |
| A | GLU516 |
| A | LEU517 |
| A | HOH704 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | LEU425 |
| A | TRP426 |
| A | TYR427 |
| A | GLN509 |
| A | ASP511 |
| A | HOH845 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | LEU486 |
| A | SER489 |
| A | LEU491 |
| A | GLN524 |
| A | LYS528 |
| A | HOH957 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | TRP88 |
| A | HOH710 |
| A | HOH859 |
| B | VAL21 |
| B | LYS22 |
| B | HOH701 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | GLN161 |
| A | ILE180 |
| A | TYR181 |
| A | GLN182 |
| B | GLU138 |
| B | THR139 |
| B | HOH771 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | ARG448 |
| A | THR473 |
| A | ASN474 |
| A | GLN475 |
| A | HOH883 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| A | GLU6 |
| A | HOH874 |
| B | LYS49 |
| B | ILE50 |
| B | GLY51 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 612 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | GLU396 |
| A | GLU399 |
| A | THR400 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 614 |
| Chain | Residue |
| A | ARG463 |
| A | ASP488 |
| A | SER489 |
| A | GLY490 |
| A | HOH915 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 615 |
| Chain | Residue |
| A | ARG277 |
| A | ARG356 |
| A | MET357 |
| A | ARG358 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 616 |
| Chain | Residue |
| A | ARG277 |
| A | GLN334 |
| A | ARG356 |
| A | LYS512 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 617 |
| Chain | Residue |
| A | TYR532 |
| A | LEU533 |
| A | HOH714 |
| A | HOH731 |
| A | HOH762 |
| A | HOH953 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 618 |
| Chain | Residue |
| A | ASN136 |
| A | ASN137 |
| A | HOH715 |
| B | GLU328 |
| B | PHE346 |
| B | LYS390 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| A | GLN85 |
| B | GLU53 |
| B | PRO55 |
| B | TYR56 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | THR403 |
| A | GLU404 |
| A | TYR405 |
| A | TRP406 |
| B | LYS331 |
| B | GLN332 |
| B | LYS424 |
| B | HOH695 |
| B | HOH791 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | LYS275 |
| B | VAL276 |
| B | ARG277 |
| B | HOH784 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | LEU234 |
| B | HIS235 |
| B | TRP239 |
| B | EDO509 |
| B | HOH810 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | TRP24 |
| B | GLU399 |
| B | TRP402 |
| B | HOH610 |
| B | HOH621 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | VAL75 |
| B | PHE77 |
| B | ASN81 |
| B | GLY152 |
| B | TRP410 |
| B | ILE411 |
| B | HOH612 |
| B | HOH699 |
| B | HOH793 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| A | SER162 |
| B | ILE50 |
| B | GLY51 |
| B | PRO52 |
| B | HOH664 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | VAL108 |
| B | ASP186 |
| B | HOH620 |
| B | HOH685 |
| B | HOH773 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | TYR232 |
| B | LYS374 |
| B | GLU378 |
| B | SO4504 |
| B | HOH766 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| A | ILE380 |
| A | HOH907 |
| B | THR27 |
| B | THR400 |
| B | TRP401 |
| B | GLU404 |
| B | HOH662 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | PRO157 |
| B | TYR183 |
| B | MET184 |
| B | HOH743 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| A | GLU138 |
| B | TRP426 |
| B | HOH668 |
| B | HOH712 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 513 |
| Chain | Residue |
| A | GLU432 |
| A | PRO433 |
| A | HOH904 |
| B | THR253 |
| B | ASN255 |
| B | ASP256 |
| B | HOH631 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 514 |
| Chain | Residue |
| A | HOH871 |
| B | GLU28 |
| B | ILE135 |
| B | HOH637 |
| B | HOH804 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 190 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"RT 'primer grip'"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Tryptophan repeat motif"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Essential for RT p66/p51 heterodimerization"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by viral protease; partial"} |
