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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6C01

Human ectonucleotide pyrophosphatase / phosphodiesterase 3 (ENPP3, NPP3, CD203c)

Functional Information from GO Data
ChainGOidnamespacecontents
A0002276biological_processbasophil activation involved in immune response
A0003676molecular_functionnucleic acid binding
A0004081molecular_functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
A0004528molecular_functionphosphodiesterase I activity
A0005509molecular_functioncalcium ion binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006220biological_processpyrimidine nucleotide metabolic process
A0006796biological_processphosphate-containing compound metabolic process
A0008270molecular_functionzinc ion binding
A0009143biological_processnucleoside triphosphate catabolic process
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0016324cellular_componentapical plasma membrane
A0016462molecular_functionpyrophosphatase activity
A0016787molecular_functionhydrolase activity
A0030505biological_processinorganic diphosphate transport
A0033007biological_processnegative regulation of mast cell activation involved in immune response
A0034432molecular_functionbis(5'-adenosyl)-pentaphosphatase activity
A0036219molecular_functionGTP diphosphatase activity
A0036221molecular_functionUTP diphosphatase activity
A0046034biological_processATP metabolic process
A0046872molecular_functionmetal ion binding
A0047429molecular_functionnucleoside triphosphate diphosphatase activity
A0047693molecular_functionATP diphosphatase activity
A0047710molecular_functionbis(5'-adenosyl)-triphosphatase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0050728biological_processnegative regulation of inflammatory response
A0055062biological_processphosphate ion homeostasis
A0070062cellular_componentextracellular exosome
A0070667biological_processnegative regulation of mast cell proliferation
A0106177molecular_functioncyclic-GMP-AMP hydrolase activity
A0160049biological_processnegative regulation of cGAS/STING signaling pathway
B0002276biological_processbasophil activation involved in immune response
B0003676molecular_functionnucleic acid binding
B0004081molecular_functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
B0004528molecular_functionphosphodiesterase I activity
B0005509molecular_functioncalcium ion binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006220biological_processpyrimidine nucleotide metabolic process
B0006796biological_processphosphate-containing compound metabolic process
B0008270molecular_functionzinc ion binding
B0009143biological_processnucleoside triphosphate catabolic process
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0016324cellular_componentapical plasma membrane
B0016462molecular_functionpyrophosphatase activity
B0016787molecular_functionhydrolase activity
B0030505biological_processinorganic diphosphate transport
B0033007biological_processnegative regulation of mast cell activation involved in immune response
B0034432molecular_functionbis(5'-adenosyl)-pentaphosphatase activity
B0036219molecular_functionGTP diphosphatase activity
B0036221molecular_functionUTP diphosphatase activity
B0046034biological_processATP metabolic process
B0046872molecular_functionmetal ion binding
B0047429molecular_functionnucleoside triphosphate diphosphatase activity
B0047693molecular_functionATP diphosphatase activity
B0047710molecular_functionbis(5'-adenosyl)-triphosphatase activity
B0048471cellular_componentperinuclear region of cytoplasm
B0050728biological_processnegative regulation of inflammatory response
B0055062biological_processphosphate ion homeostasis
B0070062cellular_componentextracellular exosome
B0070667biological_processnegative regulation of mast cell proliferation
B0106177molecular_functioncyclic-GMP-AMP hydrolase activity
B0160049biological_processnegative regulation of cGAS/STING signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdvaCkdrgd.CCwDFedtC
ChainResidueDetails
ACYS69-CYS89
ACYS113-CYS133
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsDomain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues770
DetailsRegion: {"description":"Phosphodiesterase","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsMotif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C02","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6C02","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C01","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues14
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C02","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C01","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-11-05

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