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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6BXJ

Structure of a single-chain beta3 integrin

Functional Information from GO Data
ChainGOidnamespacecontents
A0005178molecular_functionintegrin binding
A0007155biological_processcell adhesion
A0007229biological_processintegrin-mediated signaling pathway
A0008305cellular_componentintegrin complex
A0070527biological_processplatelet aggregation
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCgpGwlGSqC
ChainResidueDetails
ACYS397-CYS408
ACYS484-CYS495
site_idPS00243
Number of Residues14
DetailsI_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsQr..GeClCgqCvC
ChainResidueDetails
ACYS432-CYS445
ACYS473-CYS486
ACYS512-CYS525
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C
ChainResidueDetails
ACYS397-CYS410
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues46
DetailsDomain: {"description":"PSI","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues35
DetailsDomain: {"description":"I-EGF 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues36
DetailsDomain: {"description":"I-EGF 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues39
DetailsDomain: {"description":"I-EGF 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PDB","id":"4G1M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues171
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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