6BWT
2.45 Angstrom Resolution Crystal Structure Thioredoxin Reductase from Francisella tularensis.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| C | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019430 | biological_process | removal of superoxide radicals |
| D | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019430 | biological_process | removal of superoxide radicals |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 401 |
| Chain | Residue |
| A | GLY128 |
| A | LYS129 |
| A | GLY130 |
| A | ASP138 |
| A | TYR142 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | GLY283 |
| A | ASP284 |
| A | SER296 |
| A | HOH511 |
| A | HOH516 |
| A | HOH531 |
| A | GLY13 |
| A | PRO14 |
| A | ALA15 |
| A | GLY112 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | THR155 |
| A | ARG180 |
| A | HIS243 |
| A | LYS291 |
| A | HOH519 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | HIS174 |
| A | ARG175 |
| A | ARG176 |
| A | ARG180 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ASN165 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | ASP81 |
| B | VAL99 |
| B | GLU100 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | GLY13 |
| B | PRO14 |
| B | ALA15 |
| B | GLY112 |
| B | GLY283 |
| B | ASP284 |
| B | SER296 |
| B | HOH501 |
| B | HOH504 |
| B | HOH523 |
| B | HOH537 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | GLY153 |
| B | ASN154 |
| B | THR155 |
| B | ILE241 |
| B | LYS291 |
| B | HOH509 |
| B | HOH521 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | GLY151 |
| B | GLY152 |
| B | HIS174 |
| B | ILE241 |
| B | ASN258 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 401 |
| Chain | Residue |
| C | ASN258 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 402 |
| Chain | Residue |
| C | SER122 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 403 |
| Chain | Residue |
| C | ARG176 |
| C | SO4406 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 C 404 |
| Chain | Residue |
| C | GLY13 |
| C | PRO14 |
| C | ALA15 |
| C | GLY112 |
| C | GLY283 |
| C | ASP284 |
| C | SER296 |
| C | HOH507 |
| C | HOH523 |
| C | HOH529 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 405 |
| Chain | Residue |
| C | GLY153 |
| C | ASN154 |
| C | THR155 |
| C | ILE241 |
| C | LYS291 |
| C | HOH515 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 406 |
| Chain | Residue |
| C | GLY151 |
| C | GLY152 |
| C | HIS174 |
| C | ARG175 |
| C | ARG180 |
| C | ILE241 |
| C | CL403 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 407 |
| Chain | Residue |
| C | GLY11 |
| C | SER12 |
| C | THR34 |
| C | GLY35 |
| C | THR111 |
| C | HOH501 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| D | GLY13 |
| D | PRO14 |
| D | ALA15 |
| D | ALA110 |
| D | GLY112 |
| D | GLY283 |
| D | ASP284 |
| D | SER296 |
| D | HOH508 |
| D | HOH522 |
| D | HOH523 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 402 |
| Chain | Residue |
| D | GLY153 |
| D | ASN154 |
| D | THR155 |
| D | HIS243 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YknkdVaVVGGGN |
| Chain | Residue | Details |
| A | CYS134-ASN154 |
