Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0051262 | biological_process | protein tetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0051262 | biological_process | protein tetramerization |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0051262 | biological_process | protein tetramerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0051262 | biological_process | protein tetramerization |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 1201 |
| Chain | Residue |
| A | GLU885 |
| A | HOH1304 |
| B | GLU885 |
| B | HOH1301 |
| C | HOH1404 |
| D | HOH1303 |
| D | HOH1305 |
| D | HOH1308 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 1202 |
| Chain | Residue |
| B | HOH1304 |
| C | TYR740 |
| C | HOH1402 |
| C | HOH1405 |
| D | TYR923 |
| D | HOH1304 |
| A | HOH1302 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue Y01 A 1203 |
| Chain | Residue |
| A | TYR597 |
| A | PHE694 |
| A | TRP695 |
| A | PHE817 |
| A | LEU818 |
| A | ASN821 |
| A | Y011208 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue Y01 A 1204 |
| Chain | Residue |
| A | MET706 |
| A | PHE710 |
| A | GLN723 |
| A | Y011208 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue Y01 A 1205 |
| Chain | Residue |
| A | LEU850 |
| A | PRO866 |
| A | TRP868 |
| A | ALA871 |
| B | LEU702 |
| B | MET706 |
| B | THR709 |
| B | PHE710 |
| B | TYR811 |
| B | Y011204 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue Y01 A 1206 |
| Chain | Residue |
| A | PHE762 |
| A | LEU815 |
| A | VAL828 |
| A | MET829 |
| A | GLY832 |
| A | Y011207 |
| D | SER851 |
| D | PHE852 |
| D | VAL917 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue Y01 A 1207 |
| Chain | Residue |
| A | TYR761 |
| A | SER765 |
| A | PHE809 |
| A | Y011206 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue Y01 A 1208 |
| Chain | Residue |
| A | MET706 |
| A | TYR811 |
| A | Y011203 |
| A | Y011204 |
| D | PRO866 |
| D | TRP868 |
| D | LEU870 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 1201 |
| Chain | Residue |
| B | HOH1302 |
| D | HOH1301 |
| D | HOH1308 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1202 |
| Chain | Residue |
| A | HOH1303 |
| B | HOH1303 |
| B | HOH1306 |
| C | HOH1403 |
| D | HOH1302 |
| D | HOH1309 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 B 1203 |
| Chain | Residue |
| A | PRO866 |
| B | MET706 |
| B | LEU707 |
| B | PHE710 |
| B | GLN723 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue Y01 B 1204 |
| Chain | Residue |
| A | LEU850 |
| A | Y011205 |
| B | TYR597 |
| B | PHE694 |
| B | TRP695 |
| B | LEU702 |
| B | PHE817 |
| B | LEU818 |
| B | ASN821 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue Y01 B 1205 |
| Chain | Residue |
| A | SER851 |
| A | LEU914 |
| A | VAL917 |
| B | TYR761 |
| B | PHE762 |
| B | VAL812 |
| B | VAL828 |
| B | MET829 |
| B | GLN952 |
| B | Y011206 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue Y01 B 1206 |
| Chain | Residue |
| B | TYR761 |
| B | SER765 |
| B | PHE809 |
| B | Y011205 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue Y01 C 1301 |
| Chain | Residue |
| C | GLY520 |
| C | MET523 |
| C | LEU524 |
| C | PHE527 |
| C | GLN540 |
| C | Y011302 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue Y01 C 1302 |
| Chain | Residue |
| B | PRO866 |
| B | ILE874 |
| C | LEU522 |
| C | TYR628 |
| C | Y011301 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue Y01 C 1303 |
| Chain | Residue |
| B | LEU850 |
| C | TYR414 |
| C | PHE511 |
| C | TRP512 |
| C | PHE634 |
| C | LEU635 |
| C | VAL637 |
| C | ASN638 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue Y01 C 1304 |
| Chain | Residue |
| C | PRO683 |
| C | TRP685 |
| C | Y011305 |
| D | MET706 |
| D | THR709 |
| D | PHE710 |
| D | Y011202 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue Y01 C 1305 |
| Chain | Residue |
| C | LEU667 |
| C | Y011304 |
| D | PHE694 |
| D | TRP695 |
| D | PHE817 |
| D | VAL820 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue Y01 C 1306 |
| Chain | Residue |
| B | SER851 |
| B | PHE852 |
| C | TYR578 |
| C | PHE579 |
| C | LEU632 |
| C | VAL645 |
| C | MET646 |
| C | GLY649 |
| C | GLN769 |
| C | Y011307 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue Y01 C 1307 |
| Chain | Residue |
| C | TYR578 |
| C | ILE625 |
| C | PHE626 |
| C | Y011306 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue Y01 C 1308 |
| Chain | Residue |
| C | SER668 |
| C | PHE669 |
| C | LEU731 |
| D | PHE762 |
| D | ILE808 |
| D | VAL812 |
| D | LEU815 |
| D | VAL828 |
| D | GLN952 |
| D | Y011203 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 1201 |
| Chain | Residue |
| B | PHE883 |
| C | HOH1402 |
| D | HOH1307 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue Y01 D 1202 |
| Chain | Residue |
| C | Y011304 |
| D | GLY703 |
| D | PHE710 |
| D | GLN723 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue Y01 D 1203 |
| Chain | Residue |
| C | LEU731 |
| C | Y011308 |
| D | TYR761 |
| D | ILE808 |
| D | PHE809 |
| D | VAL812 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN594-TYR614 | |
| A | PHE694-VAL714 | |
| A | TRP757-PHE777 | |
| A | LEU801-ASN821 | |
| A | MET834-VAL854 | |
| A | PHE913-PHE933 | |
| B | ASN594-TYR614 | |
| B | PHE694-VAL714 | |
| B | TRP757-PHE777 | |
| B | LEU801-ASN821 | |
| B | MET834-VAL854 | |
| B | PHE913-PHE933 | |
| C | ASN411-TYR431 | |
| C | PHE511-VAL531 | |
| C | TRP574-PHE594 | |
| C | LEU618-ASN638 | |
| C | MET651-VAL671 | |
| C | PHE730-PHE750 | |
| D | ASN594-TYR614 | |
| D | PHE694-VAL714 | |
| D | TRP757-PHE777 | |
| D | LEU801-ASN821 | |
| D | MET834-VAL854 | |
| D | PHE913-PHE933 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 540 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS615-LYS693 | |
| A | GLY778-ARG800 | |
| A | PRO855-ASP873 | |
| A | ALA895-PRO912 | |
| B | LYS615-LYS693 | |
| B | GLY778-ARG800 | |
| B | PRO855-ASP873 | |
| B | ALA895-PRO912 | |
| C | LYS432-LYS510 | |
| C | GLY595-ARG617 | |
| C | PRO672-ASP690 | |
| C | ALA712-PRO729 | |
| D | LYS615-LYS693 | |
| D | GLY778-ARG800 | |
| D | PRO855-ASP873 | |
| D | ALA895-PRO912 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 208 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS715-VAL756 | |
| A | GLN822-LYS833 | |
| B | LYS715-VAL756 | |
| B | GLN822-LYS833 | |
| C | LYS532-VAL573 | |
| C | GLN639-LYS650 | |
| D | LYS715-VAL756 | |
| D | GLN822-LYS833 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | INTRAMEM: Pore-forming => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE874-CYS894 | |
| B | ILE874-CYS894 | |
| C | ILE691-CYS711 | |
| D | ILE874-CYS894 | |
| Chain | Residue | Details |
| A | SER1062 | |
| A | SER1138 | |
| B | SER1062 | |
| B | SER1138 | |
| C | SER879 | |
| C | SER955 | |
| D | SER1062 | |
| D | SER1138 | |
| Chain | Residue | Details |
| A | SER1093 | |
| B | SER1093 | |
| C | SER910 | |
| D | SER1093 | |
