6BW4

Crystal structure of RBBP4 in complex with PRDM16 N-terminal peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006335	biological_process	DNA replication-dependent chromatin assembly
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007420	biological_process	brain development
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016581	cellular_component	NuRD complex
A	0016589	cellular_component	NURF complex
A	0030336	biological_process	negative regulation of cell migration
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0031492	molecular_function	nucleosomal DNA binding
A	0032991	cellular_component	protein-containing complex
A	0033186	cellular_component	CAF-1 complex
A	0035098	cellular_component	ESC/E(Z) complex
A	0042393	molecular_function	histone binding
A	0042659	biological_process	regulation of cell fate specification
A	0042826	molecular_function	histone deacetylase binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0070822	cellular_component	Sin3-type complex
A	1902455	biological_process	negative regulation of stem cell population maintenance
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1904949	cellular_component	ATPase complex
A	2000736	biological_process	regulation of stem cell differentiation
C	0000118	cellular_component	histone deacetylase complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006335	biological_process	DNA replication-dependent chromatin assembly
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0007420	biological_process	brain development
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016581	cellular_component	NuRD complex
C	0016589	cellular_component	NURF complex
C	0030336	biological_process	negative regulation of cell migration
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0031492	molecular_function	nucleosomal DNA binding
C	0032991	cellular_component	protein-containing complex
C	0033186	cellular_component	CAF-1 complex
C	0035098	cellular_component	ESC/E(Z) complex
C	0042393	molecular_function	histone binding
C	0042659	biological_process	regulation of cell fate specification
C	0042826	molecular_function	histone deacetylase binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0070822	cellular_component	Sin3-type complex
C	1902455	biological_process	negative regulation of stem cell population maintenance
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1904949	cellular_component	ATPase complex
C	2000736	biological_process	regulation of stem cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI

Chain	Residue	Details
C	LEU193-ILE207
C	LEU289-LEU303
C	LEU333-LEU347

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
C	ALA2
A	ALA2

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS4
A	LYS4

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER110
A	SER110

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60972

Chain	Residue	Details
C	LYS160
A	LYS160

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER355
A	SER355

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
C	LYS4
A	LYS4

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site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS160
A	LYS160

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