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6BSS

JAK2 JH2 in complex with NU6102

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue GOL A 901
ChainResidue
AASN673
AARG715
ATRP718
AHOH1034

site_idAC2
Number of Residues10
Detailsbinding site for residue 4SP A 902
ChainResidue
AVAL629
ALYS630
AGLY632
ALEU680
AHOH1032
ALEU551
ALEU579
AGLN626
AGLU627
APHE628

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
AASP710

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR570

229380

PDB entries from 2024-12-25

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