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6BQR

Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0002407biological_processdendritic cell chemotaxis
A0002724biological_processregulation of T cell cytokine production
A0005216molecular_functionmonoatomic ion channel activity
A0005227molecular_functioncalcium-activated cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008284biological_processpositive regulation of cell population proliferation
A0010460biological_processpositive regulation of heart rate
A0016020cellular_componentmembrane
A0016925biological_processprotein sumoylation
A0019722biological_processcalcium-mediated signaling
A0030502biological_processnegative regulation of bone mineralization
A0034220biological_processmonoatomic ion transmembrane transport
A0034706cellular_componentsodium channel complex
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0043025cellular_componentneuronal cell body
A0045600biological_processpositive regulation of fat cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071318biological_processcellular response to ATP
A0086045biological_processmembrane depolarization during AV node cell action potential
A0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
A0086048biological_processmembrane depolarization during bundle of His cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0098662biological_processinorganic cation transmembrane transport
A0098719biological_processsodium ion import across plasma membrane
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
A0099604molecular_functionligand-gated calcium channel activity
A1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
A1904179biological_processpositive regulation of adipose tissue development
A1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
B0000166molecular_functionnucleotide binding
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0002407biological_processdendritic cell chemotaxis
B0002724biological_processregulation of T cell cytokine production
B0005216molecular_functionmonoatomic ion channel activity
B0005227molecular_functioncalcium-activated cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008284biological_processpositive regulation of cell population proliferation
B0010460biological_processpositive regulation of heart rate
B0016020cellular_componentmembrane
B0016925biological_processprotein sumoylation
B0019722biological_processcalcium-mediated signaling
B0030502biological_processnegative regulation of bone mineralization
B0034220biological_processmonoatomic ion transmembrane transport
B0034706cellular_componentsodium channel complex
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0043025cellular_componentneuronal cell body
B0045600biological_processpositive regulation of fat cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071318biological_processcellular response to ATP
B0086045biological_processmembrane depolarization during AV node cell action potential
B0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
B0086048biological_processmembrane depolarization during bundle of His cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0098662biological_processinorganic cation transmembrane transport
B0098719biological_processsodium ion import across plasma membrane
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
B0099604molecular_functionligand-gated calcium channel activity
B1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
B1904179biological_processpositive regulation of adipose tissue development
B1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
C0000166molecular_functionnucleotide binding
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0002407biological_processdendritic cell chemotaxis
C0002724biological_processregulation of T cell cytokine production
C0005216molecular_functionmonoatomic ion channel activity
C0005227molecular_functioncalcium-activated cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005654cellular_componentnucleoplasm
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008284biological_processpositive regulation of cell population proliferation
C0010460biological_processpositive regulation of heart rate
C0016020cellular_componentmembrane
C0016925biological_processprotein sumoylation
C0019722biological_processcalcium-mediated signaling
C0030502biological_processnegative regulation of bone mineralization
C0034220biological_processmonoatomic ion transmembrane transport
C0034706cellular_componentsodium channel complex
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0043025cellular_componentneuronal cell body
C0045600biological_processpositive regulation of fat cell differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045907biological_processpositive regulation of vasoconstriction
C0046872molecular_functionmetal ion binding
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071318biological_processcellular response to ATP
C0086045biological_processmembrane depolarization during AV node cell action potential
C0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
C0086048biological_processmembrane depolarization during bundle of His cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0098662biological_processinorganic cation transmembrane transport
C0098719biological_processsodium ion import across plasma membrane
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
C0099604molecular_functionligand-gated calcium channel activity
C1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
C1904179biological_processpositive regulation of adipose tissue development
C1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
D0000166molecular_functionnucleotide binding
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0002407biological_processdendritic cell chemotaxis
D0002724biological_processregulation of T cell cytokine production
D0005216molecular_functionmonoatomic ion channel activity
D0005227molecular_functioncalcium-activated cation channel activity
D0005262molecular_functioncalcium channel activity
D0005272molecular_functionsodium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005654cellular_componentnucleoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008284biological_processpositive regulation of cell population proliferation
D0010460biological_processpositive regulation of heart rate
D0016020cellular_componentmembrane
D0016925biological_processprotein sumoylation
D0019722biological_processcalcium-mediated signaling
D0030502biological_processnegative regulation of bone mineralization
D0034220biological_processmonoatomic ion transmembrane transport
D0034706cellular_componentsodium channel complex
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0043025cellular_componentneuronal cell body
D0045600biological_processpositive regulation of fat cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045907biological_processpositive regulation of vasoconstriction
D0046872molecular_functionmetal ion binding
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071318biological_processcellular response to ATP
D0086045biological_processmembrane depolarization during AV node cell action potential
D0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
D0086048biological_processmembrane depolarization during bundle of His cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0098662biological_processinorganic cation transmembrane transport
D0098719biological_processsodium ion import across plasma membrane
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
D0099604molecular_functionligand-gated calcium channel activity
D1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
D1904179biological_processpositive regulation of adipose tissue development
D1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues492
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581
ChainResidueDetails
APHE783-VAL803
BLEU887-PHE910
BPHE931-LEU951
BVAL1020-ILE1040
CPHE783-VAL803
CLEU815-GLY835
CTRP864-THR884
CLEU887-PHE910
CPHE931-LEU951
CVAL1020-ILE1040
DPHE783-VAL803
ALEU815-GLY835
DLEU815-GLY835
DTRP864-THR884
DLEU887-PHE910
DPHE931-LEU951
DVAL1020-ILE1040
ATRP864-THR884
ALEU887-PHE910
APHE931-LEU951
AVAL1020-ILE1040
BPHE783-VAL803
BLEU815-GLY835
BTRP864-THR884

site_idSWS_FT_FI2
Number of Residues224
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581
ChainResidueDetails
AASP804-GLU814
CPRO885-GLY886
CLEU952-LEU963
CVAL985-LEU1019
DASP804-GLU814
DPRO885-GLY886
DLEU952-LEU963
DVAL985-LEU1019
APRO885-GLY886
ALEU952-LEU963
AVAL985-LEU1019
BASP804-GLU814
BPRO885-GLY886
BLEU952-LEU963
BVAL985-LEU1019
CASP804-GLU814

site_idSWS_FT_FI3
Number of Residues184
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581
ChainResidueDetails
AGLY836-SER863
ATHR911-VAL930
BGLY836-SER863
BTHR911-VAL930
CGLY836-SER863
CTHR911-VAL930
DGLY836-SER863
DTHR911-VAL930

site_idSWS_FT_FI4
Number of Residues80
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581
ChainResidueDetails
AARG964-ASP984
BARG964-ASP984
CARG964-ASP984
DARG964-ASP984

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7TN37
ChainResidueDetails
AARG171
BARG171
CARG171
DARG171

site_idSWS_FT_FI6
Number of Residues8
DetailsBINDING: in other chain => ECO:0000250|UniProtKB:Q7TN37
ChainResidueDetails
AARG421
AGLY448
BARG421
BGLY448
CARG421
CGLY448
DARG421
DGLY448

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0007744|PDB:6BQV
ChainResidueDetails
AGLU828
DGLU828
DGLN831
DASN865
AGLN831
AASN865
BGLU828
BGLN831
BASN865
CGLU828
CGLN831
CASN865

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:29217581, ECO:0007744|PDB:6BQV
ChainResidueDetails
AASP868
BASP868
CASP868
DASP868

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000305|PubMed:15590641
ChainResidueDetails
ASER1145
ASER1152
BSER1145
BSER1152
CSER1145
CSER1152
DSER1145
DSER1152

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29217581
ChainResidueDetails
AASN992
BASN992
CASN992
DASN992

218853

PDB entries from 2024-04-24

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