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6BOM

Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004108molecular_functioncitrate (Si)-synthase activity
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006099biological_processtricarboxylic acid cycle
A0016740molecular_functiontransferase activity
A0019629biological_processpropionate catabolic process, 2-methylcitrate cycle
A0036440molecular_functioncitrate synthase activity
A0042802molecular_functionidentical protein binding
A0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
A0050440molecular_function2-methylcitrate synthase activity
B0004108molecular_functioncitrate (Si)-synthase activity
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006099biological_processtricarboxylic acid cycle
B0016740molecular_functiontransferase activity
B0019629biological_processpropionate catabolic process, 2-methylcitrate cycle
B0036440molecular_functioncitrate synthase activity
B0042802molecular_functionidentical protein binding
B0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
B0050440molecular_function2-methylcitrate synthase activity
C0004108molecular_functioncitrate (Si)-synthase activity
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006099biological_processtricarboxylic acid cycle
C0016740molecular_functiontransferase activity
C0019629biological_processpropionate catabolic process, 2-methylcitrate cycle
C0036440molecular_functioncitrate synthase activity
C0042802molecular_functionidentical protein binding
C0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
C0050440molecular_function2-methylcitrate synthase activity
D0004108molecular_functioncitrate (Si)-synthase activity
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006099biological_processtricarboxylic acid cycle
D0016740molecular_functiontransferase activity
D0019629biological_processpropionate catabolic process, 2-methylcitrate cycle
D0036440molecular_functioncitrate synthase activity
D0042802molecular_functionidentical protein binding
D0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
D0050440molecular_function2-methylcitrate synthase activity
E0004108molecular_functioncitrate (Si)-synthase activity
E0005739cellular_componentmitochondrion
E0005759cellular_componentmitochondrial matrix
E0006099biological_processtricarboxylic acid cycle
E0016740molecular_functiontransferase activity
E0019629biological_processpropionate catabolic process, 2-methylcitrate cycle
E0036440molecular_functioncitrate synthase activity
E0042802molecular_functionidentical protein binding
E0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
E0050440molecular_function2-methylcitrate synthase activity
F0004108molecular_functioncitrate (Si)-synthase activity
F0005739cellular_componentmitochondrion
F0005759cellular_componentmitochondrial matrix
F0006099biological_processtricarboxylic acid cycle
F0016740molecular_functiontransferase activity
F0019629biological_processpropionate catabolic process, 2-methylcitrate cycle
F0036440molecular_functioncitrate synthase activity
F0042802molecular_functionidentical protein binding
F0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
F0050440molecular_function2-methylcitrate synthase activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue TRS B 501
ChainResidue
BPRO33
BASP34
BTHR37
BHOH732
BHOH776
BHOH778
DLYS157
DPHE159
DHOH535

Functional Information from PROSITE/UniProt
site_idPS00480
Number of Residues13
DetailsCITRATE_SYNTHASE Citrate synthase signature. GYGHgVl.RkpDPR
ChainResidueDetails
AGLY348-ARG360

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:O34002
ChainResidueDetails
AHIS305
DHIS305
DHIS351
DASP408
EHIS305
EHIS351
EASP408
FHIS305
FHIS351
FASP408
AHIS351
AASP408
BHIS305
BHIS351
BASP408
CHIS305
CHIS351
CASP408

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:I6Y9Q3
ChainResidueDetails
AHIS269
DHIS269
DARG360
DARG434
EHIS269
EARG360
EARG434
FHIS269
FARG360
FARG434
AARG360
AARG434
BHIS269
BARG360
BARG434
CHIS269
CARG360
CARG434

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O34002
ChainResidueDetails
AVAL345
BVAL345
CVAL345
DVAL345
EVAL345
FVAL345

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PDB entries from 2024-07-31

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