6BOL
Crystal structure of mutant 2-methylcitrate synthase mcsAG419A from Aspergillus fumigatus.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019629 | biological_process | propionate catabolic process, 2-methylcitrate cycle |
| A | 0036440 | molecular_function | citrate synthase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| A | 0050440 | molecular_function | 2-methylcitrate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019629 | biological_process | propionate catabolic process, 2-methylcitrate cycle |
| B | 0036440 | molecular_function | citrate synthase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0050440 | molecular_function | 2-methylcitrate synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 501 |
| Chain | Residue |
| A | ARG344 |
| B | GLY189 |
| B | LEU190 |
| B | SER191 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue OAA A 501 |
| Chain | Residue |
| A | LYS46 |
| A | LEU49 |
| A | HIS95 |
| B | LEU461 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue OAA A 502 |
| Chain | Residue |
| A | LYS192 |
| A | ALA193 |
| A | HOH660 |
| A | ARG47 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 503 |
| Chain | Residue |
| A | LYS54 |
| A | GLN421 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 504 |
| Chain | Residue |
| A | HIS269 |
| A | ASN273 |
| A | HIS305 |
| A | HIS351 |
| A | HOH606 |
| A | HOH616 |
| B | ARG454 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | ASP34 |
| A | LEU35 |
| A | HOH662 |
Functional Information from PROSITE/UniProt
| site_id | PS00480 |
| Number of Residues | 13 |
| Details | CITRATE_SYNTHASE Citrate synthase signature. GYGHgVl.RkpDPR |
| Chain | Residue | Details |
| B | GLY348-ARG360 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"O34002","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"31141475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
