6BOB

Cryo-EM structure of rat TRPV6* in nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	488
Details	TRANSMEM: Helical => ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326

Chain	Residue	Details
A	TYR327-VAL347
A	LEU385-PHE407
A	PRO423-ARG442
A	GLU449-ALA468
A	LEU489-PHE511
A	ILE556-MET576
B	TYR327-VAL347
B	LEU385-PHE407
B	PRO423-ARG442
B	GLU449-ALA468
B	LEU489-PHE511
B	ILE556-MET576
C	TYR327-VAL347
C	LEU385-PHE407
C	PRO423-ARG442
C	GLU449-ALA468
C	LEU489-PHE511
C	ILE556-MET576
D	TYR327-VAL347
D	LEU385-PHE407
D	PRO423-ARG442
D	GLU449-ALA468
D	LEU489-PHE511
D	ILE556-MET576

---

site_id	SWS_FT_FI2
Number of Residues	252
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326

Chain	Residue	Details
A	TYR348-ARG384
A	LEU443-GLY448
A	GLN512-ASP524
A	ASN545-SER555
B	TYR348-ARG384
B	LEU443-GLY448
B	GLN512-ASP524
B	ASN545-SER555
C	TYR348-ARG384
C	LEU443-GLY448
C	GLN512-ASP524
C	ASN545-SER555
D	TYR348-ARG384
D	LEU443-GLY448
D	GLN512-ASP524
D	ASN545-SER555

---

site_id	SWS_FT_FI3
Number of Residues	132
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326

Chain	Residue	Details
A	ARG408-GLY422
A	ARG469-ASP488
B	ARG408-GLY422
B	ARG469-ASP488
C	ARG408-GLY422
C	ARG469-ASP488
D	ARG408-GLY422
D	ARG469-ASP488

---

site_id	SWS_FT_FI4
Number of Residues	76
Details	INTRAMEM: Pore-forming => ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326

Chain	Residue	Details
A	TYR525-ALA544
B	TYR525-ALA544
C	TYR525-ALA544
D	TYR525-ALA544

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27296226, ECO:0007744|PDB:5IWK, ECO:0007744|PDB:5IWP

Chain	Residue	Details
A	ASP541
B	ASP541
C	ASP541
D	ASP541

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:17197020

Chain	Residue	Details
A	TYR161
A	TYR162
B	TYR161
B	TYR162
C	TYR161
C	TYR162
D	TYR161
D	TYR162

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN357
B	ASN357
C	ASN357
D	ASN357

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