6BNI
Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and Adenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLY249 |
| A | GLY516 |
| A | HOH877 |
| A | HOH1022 |
| A | ALA250 |
| A | GLU273 |
| A | ARG295 |
| A | GLU311 |
| A | TYR313 |
| A | ASN467 |
| A | TYR469 |
| A | GLU471 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue ADN A 602 |
| Chain | Residue |
| A | ASN293 |
| A | GLU297 |
| A | THR302 |
| A | HIS303 |
| A | ASN304 |
| A | PHE307 |
| A | ALA309 |
| A | GLU464 |
| A | LEU465 |
| A | GLY520 |
| A | ARG523 |
| A | ILE534 |
| A | HOH956 |
| A | HOH1022 |
| A | HOH1038 |
| A | HOH1128 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | ARG253 |
| A | ARG253 |
| A | HOH808 |
| A | HOH808 |
| A | HOH975 |
| B | ASN260 |
| B | ASN260 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | GLU297 |
| A | GLY298 |
| A | ASP300 |
| A | HIS303 |
| A | HOH1055 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | GLY89 |
| A | ILE91 |
| A | LYS164 |
| A | PHE171 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | ARG227 |
| A | ILE290 |
| A | HOH1117 |
| B | ARG227 |
| B | GLU237 |
| B | EDO607 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | MET242 |
| A | GLY291 |
| A | LYS292 |
| A | HOH843 |
| B | MET242 |
| B | GLY291 |
| B | LYS292 |
| B | HOH850 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | ILE246 |
| A | LEU274 |
| A | TYR275 |
| A | GLN278 |
| A | ASP500 |
| A | THR502 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | PRO441 |
| A | ARG455 |
| A | ASN467 |
| A | HOH954 |
| A | HOH1041 |
| A | HOH1080 |
| A | HOH1109 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | THR424 |
| A | THR427 |
| A | LEU461 |
| A | HOH1252 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| A | ASN85 |
| A | HIS446 |
| A | ARG447 |
| A | GLU448 |
| A | PRO450 |
| A | HOH897 |
| A | HOH1035 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 612 |
| Chain | Residue |
| A | THR361 |
| A | HOH1113 |
| A | HOH1217 |
| A | HOH1250 |
| B | HOH1138 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | HOH932 |
| B | GLY249 |
| B | ALA250 |
| B | GLU273 |
| B | ARG295 |
| B | GLU311 |
| B | TYR313 |
| B | ASN467 |
| B | TYR469 |
| B | GLU471 |
| B | GLY516 |
| B | HOH836 |
| B | HOH888 |
| site_id | AD5 |
| Number of Residues | 16 |
| Details | binding site for residue ADN B 602 |
| Chain | Residue |
| B | ASN293 |
| B | GLU297 |
| B | THR302 |
| B | HIS303 |
| B | ASN304 |
| B | PHE307 |
| B | ALA309 |
| B | GLU464 |
| B | LEU465 |
| B | GLY520 |
| B | ARG523 |
| B | ILE534 |
| B | HOH864 |
| B | HOH915 |
| B | HOH932 |
| B | HOH1053 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| A | LYS59 |
| A | PHE65 |
| B | TRP445 |
| B | GLN477 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | GLU297 |
| B | GLY298 |
| B | ASP300 |
| B | HIS303 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| B | HIS446 |
| B | ARG447 |
| B | GLU448 |
| B | LYS449 |
| B | PRO450 |
| B | HOH902 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 606 |
| Chain | Residue |
| B | LYS82 |
| B | TYR83 |
| B | VAL86 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 607 |
| Chain | Residue |
| A | ARG227 |
| A | GLU237 |
| A | EDO606 |
| B | ARG227 |
| B | ILE290 |
| B | HOH1110 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 608 |
| Chain | Residue |
| B | THR424 |
| B | THR427 |
| B | LEU461 |
| B | HOH997 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 609 |
| Chain | Residue |
| B | ILE246 |
| B | LEU274 |
| B | TYR275 |
| B | GLN278 |
| B | ASP500 |
| B | THR502 |
| B | PHE503 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 610 |
| Chain | Residue |
| B | TYR247 |
| B | GLY248 |
| B | ARG269 |
| B | ILE270 |
| B | ALA271 |
| B | HOH899 |
| B | HOH911 |
