6BKK
Influenza A M2 transmembrane domain bound to amantadine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
| E | 0015078 | molecular_function | proton transmembrane transporter activity |
| E | 0033644 | cellular_component | host cell membrane |
| E | 0055036 | cellular_component | virion membrane |
| E | 1902600 | biological_process | proton transmembrane transport |
| F | 0015078 | molecular_function | proton transmembrane transporter activity |
| F | 0033644 | cellular_component | host cell membrane |
| F | 0055036 | cellular_component | virion membrane |
| F | 1902600 | biological_process | proton transmembrane transport |
| G | 0015078 | molecular_function | proton transmembrane transporter activity |
| G | 0033644 | cellular_component | host cell membrane |
| G | 0055036 | cellular_component | virion membrane |
| G | 1902600 | biological_process | proton transmembrane transport |
| H | 0015078 | molecular_function | proton transmembrane transporter activity |
| H | 0033644 | cellular_component | host cell membrane |
| H | 0055036 | cellular_component | virion membrane |
| H | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue 308 B 101 |
| Chain | Residue |
| A | SER31 |
| B | ALA30 |
| B | SER31 |
| C | SER31 |
| D | SER31 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 101 |
| Chain | Residue |
| A | SER23 |
| B | SER23 |
| C | SER23 |
| D | SER23 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL E 101 |
| Chain | Residue |
| E | SER23 |
| F | SER23 |
| G | SER23 |
| H | SER23 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue 308 F 101 |
| Chain | Residue |
| E | SER31 |
| E | HOH204 |
| F | ALA30 |
| F | SER31 |
| G | SER31 |
| G | HOH104 |
| H | SER31 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide ACE B 21 and SER B 22 |
| Chain | Residue |
| A | SER22 |
| A | ASP24 |
| B | SER23 |
| B | HOH202 |
| C | ACE21 |
| C | SER22 |
| C | HOH201 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ACE C 21 and SER C 22 |
| Chain | Residue |
| B | SER22 |
| B | SER23 |
| B | HOH202 |
| C | SER23 |
| C | HOH201 |
| D | SER22 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE F 21 and SER F 22 |
| Chain | Residue |
| C | PRO25 |
| C | HOH204 |
| E | SER22 |
| F | SER23 |
| F | HOH205 |
| G | ACE21 |
| G | SER22 |
| G | HOH101 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE G 21 and SER G 22 |
| Chain | Residue |
| C | ASP24 |
| D | SER22 |
| F | SER22 |
| F | SER23 |
| G | SER23 |
| G | HOH101 |
| G | HOH106 |
| H | SER22 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ACE H 21 and SER H 22 |
| Chain | Residue |
| E | SER22 |
| G | SER22 |
| G | SER23 |
| G | HOH101 |
| H | SER23 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER23-LEU43 | |
| B | SER23-LEU43 | |
| C | SER23-LEU43 | |
| D | SER23-LEU43 | |
| E | SER23-LEU43 | |
| F | SER23-LEU43 | |
| G | SER23-LEU43 | |
| H | SER23-LEU43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | HIS37 | |
| B | HIS37 | |
| C | HIS37 | |
| D | HIS37 | |
| E | HIS37 | |
| F | HIS37 | |
| G | HIS37 | |
| H | HIS37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | TRP41 | |
| B | TRP41 | |
| C | TRP41 | |
| D | TRP41 | |
| E | TRP41 | |
| F | TRP41 | |
| G | TRP41 | |
| H | TRP41 |
