6BKK

Influenza A M2 transmembrane domain bound to amantadine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015078	molecular_function	proton transmembrane transporter activity
A	0033644	cellular_component	host cell membrane
A	0055036	cellular_component	virion membrane
A	1902600	biological_process	proton transmembrane transport
B	0015078	molecular_function	proton transmembrane transporter activity
B	0033644	cellular_component	host cell membrane
B	0055036	cellular_component	virion membrane
B	1902600	biological_process	proton transmembrane transport
C	0015078	molecular_function	proton transmembrane transporter activity
C	0033644	cellular_component	host cell membrane
C	0055036	cellular_component	virion membrane
C	1902600	biological_process	proton transmembrane transport
D	0015078	molecular_function	proton transmembrane transporter activity
D	0033644	cellular_component	host cell membrane
D	0055036	cellular_component	virion membrane
D	1902600	biological_process	proton transmembrane transport
E	0015078	molecular_function	proton transmembrane transporter activity
E	0033644	cellular_component	host cell membrane
E	0055036	cellular_component	virion membrane
E	1902600	biological_process	proton transmembrane transport
F	0015078	molecular_function	proton transmembrane transporter activity
F	0033644	cellular_component	host cell membrane
F	0055036	cellular_component	virion membrane
F	1902600	biological_process	proton transmembrane transport
G	0015078	molecular_function	proton transmembrane transporter activity
G	0033644	cellular_component	host cell membrane
G	0055036	cellular_component	virion membrane
G	1902600	biological_process	proton transmembrane transport
H	0015078	molecular_function	proton transmembrane transporter activity
H	0033644	cellular_component	host cell membrane
H	0055036	cellular_component	virion membrane
H	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue 308 B 101

Chain	Residue
A	SER31
B	ALA30
B	SER31
C	SER31
D	SER31

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL C 101

Chain	Residue
A	SER23
B	SER23
C	SER23
D	SER23

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL E 101

Chain	Residue
E	SER23
F	SER23
G	SER23
H	SER23

---

site_id	AC4
Number of Residues	7
Details	binding site for residue 308 F 101

Chain	Residue
E	SER31
E	HOH204
F	ALA30
F	SER31
G	SER31
G	HOH104
H	SER31

---

site_id	AC5
Number of Residues	7
Details	binding site for Di-peptide ACE B 21 and SER B 22

Chain	Residue
A	SER22
A	ASP24
B	SER23
B	HOH202
C	ACE21
C	SER22
C	HOH201

---

site_id	AC6
Number of Residues	6
Details	binding site for Di-peptide ACE C 21 and SER C 22

Chain	Residue
B	SER22
B	SER23
B	HOH202
C	SER23
C	HOH201
D	SER22

---

site_id	AC7
Number of Residues	8
Details	binding site for Di-peptide ACE F 21 and SER F 22

Chain	Residue
C	PRO25
C	HOH204
E	SER22
F	SER23
F	HOH205
G	ACE21
G	SER22
G	HOH101

---

site_id	AC8
Number of Residues	8
Details	binding site for Di-peptide ACE G 21 and SER G 22

Chain	Residue
C	ASP24
D	SER22
F	SER22
F	SER23
G	SER23
G	HOH101
G	HOH106
H	SER22

---

site_id	AC9
Number of Residues	5
Details	binding site for Di-peptide ACE H 21 and SER H 22

Chain	Residue
E	SER22
G	SER22
G	SER23
G	HOH101
H	SER23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Site: {"description":"Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Seems to be involved in pH gating","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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