6BJ8
TCR55 in complex with Pep20/HLA-B35
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001913 | biological_process | T cell mediated cytotoxicity |
| B | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| B | 0002237 | biological_process | response to molecule of bacterial origin |
| B | 0002376 | biological_process | immune system process |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0002726 | biological_process | positive regulation of T cell cytokine production |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006955 | biological_process | immune response |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007611 | biological_process | learning or memory |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0010038 | biological_process | response to metal ion |
| B | 0010977 | biological_process | negative regulation of neuron projection development |
| B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031905 | cellular_component | early endosome lumen |
| B | 0033077 | biological_process | T cell differentiation in thymus |
| B | 0033572 | biological_process | transferrin transport |
| B | 0034756 | biological_process | regulation of iron ion transport |
| B | 0034757 | biological_process | negative regulation of iron ion transport |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042026 | biological_process | protein refolding |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0045646 | biological_process | regulation of erythrocyte differentiation |
| B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| B | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0050768 | biological_process | negative regulation of neurogenesis |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0071283 | biological_process | cellular response to iron(III) ion |
| B | 0071316 | biological_process | cellular response to nicotine |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1990000 | biological_process | amyloid fibril formation |
| B | 1990712 | cellular_component | HFE-transferrin receptor complex |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| H | 0002376 | biological_process | immune system process |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0042101 | cellular_component | T cell receptor complex |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | GLN54 |
| A | GLY56 |
| A | PRO57 |
| A | HOH457 |
| A | HOH505 |
| D | ASN22 |
| D | LYS68 |
| D | ALA75 |
| D | HOH421 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | THR31 |
| A | THR178 |
| A | ASP183 |
| A | TYR209 |
| A | ARG239 |
| A | HOH435 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ARG6 |
| A | PHE8 |
| A | ASP29 |
| A | ASP30 |
| A | HOH405 |
| A | HOH478 |
| B | HOH206 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | TYR84 |
| A | TYR85 |
| A | THR138 |
| A | ARG219 |
| A | ASP220 |
| A | GLU222 |
| A | HOH411 |
| A | HOH507 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | GLU166 |
| A | ARG170 |
| A | HOH475 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | HIS191 |
| A | PRO193 |
| A | ALA199 |
| A | SER251 |
| A | GLU254 |
| A | HOH453 |
| H | ASP226 |
| H | ALA228 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | ARG44 |
| A | THR45 |
| A | GLU46 |
| A | PRO47 |
| A | TRP60 |
| D | HOH499 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | ARG6 |
| A | HIS113 |
| A | GLN115 |
| A | HOH405 |
| A | HOH423 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | ARG97 |
| A | ASP114 |
| A | TRP147 |
| A | VAL152 |
| A | HOH403 |
| A | HOH483 |
| C | LEU3 |
| C | ASP6 |
| C | ALA7 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 310 |
| Chain | Residue |
| A | ARG111 |
| A | GLY112 |
| A | HIS113 |
| A | ASP114 |
| A | GLN115 |
| A | LEU126 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 311 |
| Chain | Residue |
| A | TRP204 |
| A | ARG234 |
| A | TRP244 |
| A | HOH474 |
| B | VAL9 |
| B | ASP96 |
| B | GOL101 |
| B | GOL103 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 101 |
| Chain | Residue |
| A | TRP204 |
| A | LEU206 |
| A | ARG234 |
| A | GLN242 |
| A | PO4311 |
| B | TYR10 |
| B | SER11 |
| B | HIS13 |
| B | PRO14 |
| B | HOH223 |
| B | HOH229 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 102 |
| Chain | Residue |
| A | ILE23 |
| A | ASP37 |
| B | ASP53 |
| B | LEU54 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 103 |
| Chain | Residue |
| A | PO4311 |
| B | GLN8 |
| B | VAL9 |
| B | VAL93 |
| B | LYS94 |
| B | ASP96 |
| B | HOH214 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| D | SER31 |
| D | TYR32 |
| D | GLY96 |
| D | GLN99 |
| D | HOH404 |
| D | HOH439 |
| D | HOH497 |
| D | HOH515 |
| A | GLN155 |
| C | GLU5 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| D | ASN114 |
| D | GLN116 |
| D | ASN117 |
| D | PHE170 |
| D | LYS171 |
| D | HOH413 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| A | GLU154 |
| A | ARG157 |
| D | ASP54 |
| D | GLU55 |
| D | GLN56 |
| D | HOH403 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 304 |
| Chain | Residue |
| D | VAL102 |
| D | PHE103 |
| D | HOH416 |
| D | HOH432 |
| H | LEU43 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 D 305 |
| Chain | Residue |
| D | MET165 |
| D | ARG166 |
| D | SER167 |
| D | HOH408 |
| D | HOH464 |
| D | HOH466 |
| H | SER168 |
| H | GLY169 |
| H | ARG195 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 D 306 |
| Chain | Residue |
| A | PRO50 |
| A | ARG239 |
| D | GLN2 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL H 301 |
| Chain | Residue |
| D | LYS100 |
| H | TYR47 |
| H | TYR48 |
| H | HOH495 |
| H | HOH516 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue GOL H 302 |
| Chain | Residue |
| H | TYR47 |
| H | SER49 |
| H | SER51 |
| H | GLY53 |
| H | THR54 |
| H | ARG68 |
| H | HOH413 |
| H | HOH424 |
| H | HOH433 |
| H | HOH447 |
| site_id | AE5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL H 303 |
| Chain | Residue |
| H | PRO39 |
| H | SER87 |
| H | ARG110 |
| H | LEU111 |
| H | THR112 |
| H | ASP153 |
| H | HIS154 |
| H | HOH459 |
| H | HOH470 |
| H | HOH541 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL H 304 |
| Chain | Residue |
| H | ASP116 |
| H | LYS118 |
| H | GLU222 |
| H | TRP223 |
| H | THR224 |
| H | GLN225 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL H 305 |
| Chain | Residue |
| H | VAL12 |
| H | GLN17 |
| H | LEU117 |
| H | SER218 |
| H | ASP221 |
| H | HOH490 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL H 306 |
| Chain | Residue |
| D | ASP127 |
| D | SER128 |
| D | LYS129 |
| D | HOH414 |
| H | VAL127 |
| H | GLU129 |
| H | GLU238 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL H 307 |
| Chain | Residue |
| H | PRO8 |
| H | LYS9 |
| H | PHE10 |
| H | TYR215 |
| H | HOH405 |
| H | HOH492 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL H 308 |
| Chain | Residue |
| A | ASN86 |
| A | HOH501 |
| H | ILE234 |
| H | VAL235 |
| H | SER236 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL H 309 |
| Chain | Residue |
| H | SER18 |
| H | THR20 |
| H | ARG77 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL H 310 |
| Chain | Residue |
| H | ASN162 |
| H | GLY163 |
| H | HIS207 |
| H | ARG209 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 H 311 |
| Chain | Residue |
| H | LYS164 |
| H | VAL166 |
| H | HIS167 |
| H | SER168 |
| H | HOH443 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH |
| Chain | Residue | Details |
| A | TYR257-HIS263 | |
| B | TYR78-HIS84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 |
| Chain | Residue | Details |
| B | GLN2 | |
| A | TYR84 | |
| A | THR143 | |
| A | LYS146 | |
| A | VAL152 | |
| A | TYR159 | |
| A | TYR171 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443 |
| Chain | Residue | Details |
| B | ILE1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 |
| Chain | Residue | Details |
| B | LYS19 | |
| B | LYS41 | |
| B | LYS48 | |
| B | LYS58 | |
| B | LYS91 | |
| B | LYS94 |
