6BJ7

Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 4-chloro-6-methylpyrimidin-2-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0047975	molecular_function	guanosine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue DMS A 301

Chain	Residue
A	ASN95
A	ALA99
A	ARG103
A	VAL148
A	VAL150
A	HOH424
A	HOH465

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site_id	AC2
Number of Residues	4
Details	binding site for residue DMS A 302

Chain	Residue
A	CYS231
A	HIS232
A	PRO162
A	ASP163

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site_id	AC3
Number of Residues	3
Details	binding site for residue DMS A 303

Chain	Residue
A	ARG111
A	PRO285
A	HOH455

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site_id	AC4
Number of Residues	4
Details	binding site for residue DMS A 304

Chain	Residue
A	SER35
A	PHE161
A	TYR202
A	HIS259

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site_id	AC5
Number of Residues	7
Details	binding site for residue DMS A 305

Chain	Residue
A	GLY34
A	SER35
A	ARG86
A	HIS88
A	ASN117
A	LEU118
A	SER222

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site_id	AC6
Number of Residues	10
Details	binding site for residue DU7 A 306

Chain	Residue
A	ALA119
A	GLY120
A	TYR202
A	GLU203
A	GLY220
A	MET221
A	ASN245
A	SER247
A	VAL262
A	HOH436

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