6BII
Crystal Structure of Pyrococcus yayanosii Glyoxylate Hydroxypyruvate Reductase in complex with NADP and malonate (re-refinement of 5AOW)
Replaces: 5AOWFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0047964 | molecular_function | glyoxylate reductase (NADH) activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0047964 | molecular_function | glyoxylate reductase (NADH) activity |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 39 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | VAL76 |
| A | SER182 |
| A | LYS184 |
| A | ALA211 |
| A | VAL212 |
| A | PRO213 |
| A | GLU217 |
| A | THR218 |
| A | VAL239 |
| A | ALA240 |
| A | ARG241 |
| A | THR104 |
| A | ASP265 |
| A | HIS288 |
| A | GLY290 |
| A | SER291 |
| A | MLI402 |
| A | HOH521 |
| A | HOH531 |
| A | HOH566 |
| A | HOH574 |
| A | HOH577 |
| A | GLY157 |
| A | HOH580 |
| A | HOH597 |
| A | HOH604 |
| A | HOH605 |
| A | HOH614 |
| A | HOH620 |
| A | HOH623 |
| A | HOH673 |
| A | HOH676 |
| A | HOH687 |
| A | PHE158 |
| A | GLY159 |
| A | ARG160 |
| A | ILE161 |
| A | ALA180 |
| A | ARG181 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue MLI A 402 |
| Chain | Residue |
| A | LEU53 |
| A | ALA75 |
| A | VAL76 |
| A | GLY77 |
| A | LEU100 |
| A | ARG241 |
| A | HIS288 |
| A | NAP401 |
| A | HOH516 |
| A | HOH673 |
| B | TRP138 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | TYR78 |
| A | ASN95 |
| A | ARG160 |
| A | HOH570 |
| A | HOH574 |
| A | HOH657 |
| A | HOH716 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | HIS30 |
| A | GLU31 |
| A | HIS32 |
| A | HOH690 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | GLN163 |
| A | LYS184 |
| A | PRO185 |
| A | GLU186 |
| A | ALA187 |
| A | HOH727 |
| site_id | AC6 |
| Number of Residues | 37 |
| Details | binding site for residue NAP B 401 |
| Chain | Residue |
| B | HOH615 |
| B | HOH631 |
| B | HOH638 |
| B | HOH641 |
| B | HOH663 |
| B | VAL76 |
| B | THR104 |
| B | GLY157 |
| B | PHE158 |
| B | GLY159 |
| B | ARG160 |
| B | ILE161 |
| B | ALA180 |
| B | ARG181 |
| B | SER182 |
| B | LYS184 |
| B | ALA211 |
| B | VAL212 |
| B | PRO213 |
| B | THR218 |
| B | VAL239 |
| B | ALA240 |
| B | ARG241 |
| B | ASP265 |
| B | HIS288 |
| B | GLY290 |
| B | SER291 |
| B | MLI402 |
| B | HOH529 |
| B | HOH550 |
| B | HOH551 |
| B | HOH561 |
| B | HOH566 |
| B | HOH574 |
| B | HOH593 |
| B | HOH596 |
| B | HOH614 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue MLI B 402 |
| Chain | Residue |
| A | TRP138 |
| B | LEU53 |
| B | ALA75 |
| B | VAL76 |
| B | GLY77 |
| B | LEU100 |
| B | ARG241 |
| B | HIS288 |
| B | NAP401 |
| B | HOH503 |
| B | HOH615 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | TYR78 |
| B | ASN95 |
| B | ARG160 |
| B | HOH540 |
| B | HOH561 |
| B | HOH569 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | LYS184 |
| B | PRO185 |
| B | GLU186 |
| B | ALA187 |
| B | HOH553 |
| B | HOH685 |
Functional Information from PROSITE/UniProt
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKpTaVLVNvARGkVVD |
| Chain | Residue | Details |
| A | MET230-ASP246 |
