6BIB
1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue DW7 A 201 |
| Chain | Residue |
| A | HIS30 |
| A | ALA158 |
| A | ALA159 |
| A | ALA160 |
| A | LYS162 |
| A | HOH307 |
| A | HOH323 |
| A | HOH332 |
| A | GLU54 |
| A | ARG108 |
| A | GLN110 |
| A | THR134 |
| A | ILE135 |
| A | PRO136 |
| A | CYS139 |
| A | HIS157 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue DW7 B 201 |
| Chain | Residue |
| B | GLY15 |
| B | TRP16 |
| B | HIS30 |
| B | VAL31 |
| B | GLU54 |
| B | ILE109 |
| B | GLN110 |
| B | VAL114 |
| B | THR134 |
| B | ILE135 |
| B | PRO136 |
| B | GLY137 |
| B | ASP138 |
| B | GLY140 |
| B | ALA141 |
| B | HIS157 |
| B | ALA158 |
| B | ALA159 |
| B | ALA160 |
| B | THR161 |
| B | LYS162 |
| B | HOH320 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454 |
| Chain | Residue | Details |
| A | HIS30 | |
| A | GLU54 | |
| A | CYS139 | |
| B | HIS30 | |
| B | GLU54 | |
| B | CYS139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190 |
| Chain | Residue | Details |
| A | GLU181 | |
| B | GLU181 |
