6BI1

Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with (2R)-2-amino-3-(benzyloxy)propan-1-ol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0047975	molecular_function	guanosine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue DMS A 301

Chain	Residue
A	ASN95
A	ALA99
A	ARG103
A	VAL148
A	VAL150
A	HOH459

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site_id	AC2
Number of Residues	5
Details	binding site for residue DMS A 302

Chain	Residue
A	HIS232
A	HOH424
A	PRO162
A	ASP163
A	CYS231

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site_id	AC3
Number of Residues	5
Details	binding site for residue DMS A 303

Chain	Residue
A	LEU118
A	TYR202
A	HIS259
A	VAL262
A	DMS304

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site_id	AC4
Number of Residues	8
Details	binding site for residue DMS A 304

Chain	Residue
A	SER35
A	ARG86
A	HIS88
A	ASN117
A	LEU118
A	SER222
A	DMS303
A	HOH524

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site_id	AC5
Number of Residues	2
Details	binding site for residue DMS A 305

Chain	Residue
A	PRO285
A	HOH407

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site_id	AC6
Number of Residues	4
Details	binding site for residue DMS A 306

Chain	Residue
A	GLU156
A	VAL255
A	HOH405
A	HOH628

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site_id	AC7
Number of Residues	4
Details	binding site for residue DMS A 307

Chain	Residue
A	ASP155
A	GLU156
A	HOH615
A	HOH664

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site_id	AC8
Number of Residues	8
Details	binding site for residue SEM A 308

Chain	Residue
A	ASN54
A	ASN183
A	PHE185
A	LEU272
A	MET275
A	TRP276
A	HOH453
A	HOH469

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