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6BH4

LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 5-(1-(tert-butyl)-1H-pyrazol-4-yl)-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (Compound N75/CPI-48)

Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue DQS A 601
ChainResidue
AARG73
AHIS483
AASN493
ALYS501
ATRP503
AHIS571
AASN575
AMN602
AHOH714
AHOH726
AHOH736
ATYR409
AHOH797
AGLY410
AALA411
AASP412
ATYR472
ASER478
ASER479
APHE480

site_idAC2
Number of Residues6
Detailsbinding site for residue MN A 602
ChainResidue
AHIS483
AGLU485
AHIS571
ADQS601
AHOH714
AHOH726

site_idAC3
Number of Residues4
Detailsbinding site for residue EDO A 603
ChainResidue
ALYS45
AARG73
AASP412
AHIS509

site_idAC4
Number of Residues5
Detailsbinding site for residue EDO A 604
ChainResidue
AHIS383
AVAL385
ATHR387
AGLU499
APRO500

site_idAC5
Number of Residues2
Detailsbinding site for residue EDO A 605
ChainResidue
ASER25
ATRP26

site_idAC6
Number of Residues2
Detailsbinding site for residue EDO A 606
ChainResidue
APRO53
AHOH711

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO A 607
ChainResidue
AVAL398
AILE539
AMET540
AASN541
AHOH733

site_idAC8
Number of Residues5
Detailsbinding site for residue EDO A 608
ChainResidue
ATRP470
ATYR472
AGLU485
AVAL584
AASN585

site_idAC9
Number of Residues3
Detailsbinding site for residue EDO A 609
ChainResidue
AGLN356
AVAL358
AMET384

site_idAD1
Number of Residues7
Detailsbinding site for residue GOL A 610
ChainResidue
AASN379
AMET380
AGLU485
AASP486
AHIS487
ATRP488
AHOH761

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues50
DetailsZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228
ChainResidueDetails
ATYR409
ASER491
AASN493
ALYS501

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454
ChainResidueDetails
AHIS483
AHIS571

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454
ChainResidueDetails
AGLU485

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER464

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALEU451

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PDB entries from 2024-11-20

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