6BH2
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR (R)-N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)pyrrolidin-3-yl)cyclopropanecarboxamide (Compound N54)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 601 |
| Chain | Residue |
| A | HIS483 |
| A | GLU485 |
| A | HIS571 |
| A | 90V604 |
| A | HOH734 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | HIS487 |
| A | TRP488 |
| A | HOH706 |
| A | HOH711 |
| A | HOH846 |
| A | MET380 |
| A | PRO381 |
| A | GLU485 |
| A | ASP486 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | ASP412 |
| A | TYR472 |
| A | PHE480 |
| A | 90V604 |
| A | HOH725 |
| A | HOH730 |
| A | HOH743 |
| A | HOH784 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue 90V A 604 |
| Chain | Residue |
| A | TYR409 |
| A | TYR472 |
| A | SER479 |
| A | PHE480 |
| A | HIS483 |
| A | GLU485 |
| A | SER491 |
| A | ASN493 |
| A | LYS501 |
| A | TRP503 |
| A | HIS571 |
| A | ASN575 |
| A | VAL584 |
| A | ASN585 |
| A | MN601 |
| A | GOL603 |
| A | HOH734 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | ASN556 |
| A | HOH709 |
| A | HOH715 |
| A | HOH745 |
| A | HOH771 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | VAL21 |
| A | SER528 |
| A | GLN529 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | PHE70 |
| A | THR71 |
| A | HOH794 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | LYS467 |
| A | VAL468 |
| A | TRP470 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | PRO17 |
| A | PRO551 |
| A | VAL552 |
| A | HOH707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"GSGFP motif","evidences":[{"source":"UniProtKB","id":"Q3UXZ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
