6BGJ

Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
A	0005247	molecular_function	voltage-gated chloride channel activity
A	0005254	molecular_function	chloride channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0009897	cellular_component	external side of plasma membrane
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034605	biological_process	cellular response to heat
A	0034707	cellular_component	chloride channel complex
A	0042391	biological_process	regulation of membrane potential
A	0042734	cellular_component	presynaptic membrane
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042995	cellular_component	cell projection
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0046983	molecular_function	protein dimerization activity
A	0050965	biological_process	detection of temperature stimulus involved in sensory perception of pain
A	0050966	biological_process	detection of mechanical stimulus involved in sensory perception of pain
A	0051649	biological_process	establishment of localization in cell
A	0060438	biological_process	trachea development
A	0070254	biological_process	mucus secretion
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0106091	biological_process	glial cell projection elongation
A	1902476	biological_process	chloride transmembrane transport
B	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
B	0005247	molecular_function	voltage-gated chloride channel activity
B	0005254	molecular_function	chloride channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0009897	cellular_component	external side of plasma membrane
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034605	biological_process	cellular response to heat
B	0034707	cellular_component	chloride channel complex
B	0042391	biological_process	regulation of membrane potential
B	0042734	cellular_component	presynaptic membrane
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042995	cellular_component	cell projection
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0046983	molecular_function	protein dimerization activity
B	0050965	biological_process	detection of temperature stimulus involved in sensory perception of pain
B	0050966	biological_process	detection of mechanical stimulus involved in sensory perception of pain
B	0051649	biological_process	establishment of localization in cell
B	0060438	biological_process	trachea development
B	0070254	biological_process	mucus secretion
B	0098793	cellular_component	presynapse
B	0098978	cellular_component	glutamatergic synapse
B	0106091	biological_process	glial cell projection elongation
B	1902476	biological_process	chloride transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA A 1001

Chain	Residue
A	GLU701
A	GLU730
A	ASP734

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CA B 1001

Chain	Residue
B	GLU701
B	GLU730
B	ASP734

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29236684","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236691","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	212
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29236684","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236691","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	66
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29236684","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236691","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33378669","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29236691","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Unlikely to bind calcium but may play an important structural role","evidences":[{"source":"PubMed","id":"33378669","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---