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6BE1

Cryo-EM structure of serotonin receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007210biological_processserotonin receptor signaling pathway
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0022850molecular_functionserotonin-gated monoatomic cation channel activity
A0032154cellular_componentcleavage furrow
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0051378molecular_functionserotonin binding
A0098662biological_processinorganic cation transmembrane transport
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A0140227biological_processserotonin-gated cation-selective signaling pathway
A1904602cellular_componentserotonin-activated cation-selective channel complex
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007210biological_processserotonin receptor signaling pathway
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0022850molecular_functionserotonin-gated monoatomic cation channel activity
B0032154cellular_componentcleavage furrow
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051378molecular_functionserotonin binding
B0098662biological_processinorganic cation transmembrane transport
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B0140227biological_processserotonin-gated cation-selective signaling pathway
B1904602cellular_componentserotonin-activated cation-selective channel complex
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007210biological_processserotonin receptor signaling pathway
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0022850molecular_functionserotonin-gated monoatomic cation channel activity
C0032154cellular_componentcleavage furrow
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0051378molecular_functionserotonin binding
C0098662biological_processinorganic cation transmembrane transport
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C0140227biological_processserotonin-gated cation-selective signaling pathway
C1904602cellular_componentserotonin-activated cation-selective channel complex
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0007210biological_processserotonin receptor signaling pathway
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0022850molecular_functionserotonin-gated monoatomic cation channel activity
D0032154cellular_componentcleavage furrow
D0034220biological_processmonoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051378molecular_functionserotonin binding
D0098662biological_processinorganic cation transmembrane transport
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D0140227biological_processserotonin-gated cation-selective signaling pathway
D1904602cellular_componentserotonin-activated cation-selective channel complex
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0007210biological_processserotonin receptor signaling pathway
E0015276molecular_functionligand-gated monoatomic ion channel activity
E0016020cellular_componentmembrane
E0022850molecular_functionserotonin-gated monoatomic cation channel activity
E0032154cellular_componentcleavage furrow
E0034220biological_processmonoatomic ion transmembrane transport
E0042802molecular_functionidentical protein binding
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051378molecular_functionserotonin binding
E0098662biological_processinorganic cation transmembrane transport
E0099505biological_processregulation of presynaptic membrane potential
E0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E0140227biological_processserotonin-gated cation-selective signaling pathway
E1904602cellular_componentserotonin-activated cation-selective channel complex
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC
ChainResidueDetails
ACYS135-CYS149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues130
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
APRO220-PRO246
BPRO220-PRO246
CPRO220-PRO246
DPRO220-PRO246
EPRO220-PRO246

site_idSWS_FT_FI2
Number of Residues715
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25119048
ChainResidueDetails
AASP247-ARG251
EGLU300-ARG439
AGLU300-ARG439
BASP247-ARG251
BGLU300-ARG439
CASP247-ARG251
CGLU300-ARG439
DASP247-ARG251
DGLU300-ARG439
EASP247-ARG251

site_idSWS_FT_FI3
Number of Residues90
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AVAL252-SER270
BVAL252-SER270
CVAL252-SER270
DVAL252-SER270
EVAL252-SER270

site_idSWS_FT_FI4
Number of Residues55
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:25119048
ChainResidueDetails
AASP271-THR280
EHIS460-SER462
AHIS460-SER462
BASP271-THR280
BHIS460-SER462
CASP271-THR280
CHIS460-SER462
DASP271-THR280
DHIS460-SER462
EASP271-THR280

site_idSWS_FT_FI5
Number of Residues90
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
APRO281-ALA299
BPRO281-ALA299
CPRO281-ALA299
DPRO281-ALA299
EPRO281-ALA299

site_idSWS_FT_FI6
Number of Residues95
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AILE440-TRP459
BILE440-TRP459
CILE440-TRP459
DILE440-TRP459
EILE440-TRP459

site_idSWS_FT_FI7
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN82
DASN82
DASN148
DASN164
EASN82
EASN148
EASN164
AASN148
AASN164
BASN82
BASN148
BASN164
CASN82
CASN148
CASN164

227344

PDB entries from 2024-11-13

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