Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6BCL

cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002407biological_processdendritic cell chemotaxis
A0002724biological_processregulation of T cell cytokine production
A0005216molecular_functionmonoatomic ion channel activity
A0005227molecular_functioncalcium-activated cation channel activity
A0005244molecular_functionvoltage-gated monoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008284biological_processpositive regulation of cell population proliferation
A0010460biological_processpositive regulation of heart rate
A0016020cellular_componentmembrane
A0016925biological_processprotein sumoylation
A0019722biological_processcalcium-mediated signaling
A0030502biological_processnegative regulation of bone mineralization
A0034220biological_processmonoatomic ion transmembrane transport
A0034706cellular_componentsodium channel complex
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042391biological_processregulation of membrane potential
A0043025cellular_componentneuronal cell body
A0045600biological_processpositive regulation of fat cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071318biological_processcellular response to ATP
A0086045biological_processmembrane depolarization during AV node cell action potential
A0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
A0086048biological_processmembrane depolarization during bundle of His cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0098662biological_processinorganic cation transmembrane transport
A0098719biological_processsodium ion import across plasma membrane
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
A1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
A1904179biological_processpositive regulation of adipose tissue development
A1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
B0002250biological_processadaptive immune response
B0002407biological_processdendritic cell chemotaxis
B0002724biological_processregulation of T cell cytokine production
B0005216molecular_functionmonoatomic ion channel activity
B0005227molecular_functioncalcium-activated cation channel activity
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008284biological_processpositive regulation of cell population proliferation
B0010460biological_processpositive regulation of heart rate
B0016020cellular_componentmembrane
B0016925biological_processprotein sumoylation
B0019722biological_processcalcium-mediated signaling
B0030502biological_processnegative regulation of bone mineralization
B0034220biological_processmonoatomic ion transmembrane transport
B0034706cellular_componentsodium channel complex
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042391biological_processregulation of membrane potential
B0043025cellular_componentneuronal cell body
B0045600biological_processpositive regulation of fat cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071318biological_processcellular response to ATP
B0086045biological_processmembrane depolarization during AV node cell action potential
B0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
B0086048biological_processmembrane depolarization during bundle of His cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0098662biological_processinorganic cation transmembrane transport
B0098719biological_processsodium ion import across plasma membrane
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
B1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
B1904179biological_processpositive regulation of adipose tissue development
B1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
C0002250biological_processadaptive immune response
C0002407biological_processdendritic cell chemotaxis
C0002724biological_processregulation of T cell cytokine production
C0005216molecular_functionmonoatomic ion channel activity
C0005227molecular_functioncalcium-activated cation channel activity
C0005244molecular_functionvoltage-gated monoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005654cellular_componentnucleoplasm
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008284biological_processpositive regulation of cell population proliferation
C0010460biological_processpositive regulation of heart rate
C0016020cellular_componentmembrane
C0016925biological_processprotein sumoylation
C0019722biological_processcalcium-mediated signaling
C0030502biological_processnegative regulation of bone mineralization
C0034220biological_processmonoatomic ion transmembrane transport
C0034706cellular_componentsodium channel complex
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0042391biological_processregulation of membrane potential
C0043025cellular_componentneuronal cell body
C0045600biological_processpositive regulation of fat cell differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045907biological_processpositive regulation of vasoconstriction
C0046872molecular_functionmetal ion binding
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071318biological_processcellular response to ATP
C0086045biological_processmembrane depolarization during AV node cell action potential
C0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
C0086048biological_processmembrane depolarization during bundle of His cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0098662biological_processinorganic cation transmembrane transport
C0098719biological_processsodium ion import across plasma membrane
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
C1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
C1904179biological_processpositive regulation of adipose tissue development
C1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
D0002250biological_processadaptive immune response
D0002407biological_processdendritic cell chemotaxis
D0002724biological_processregulation of T cell cytokine production
D0005216molecular_functionmonoatomic ion channel activity
D0005227molecular_functioncalcium-activated cation channel activity
D0005244molecular_functionvoltage-gated monoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005654cellular_componentnucleoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008284biological_processpositive regulation of cell population proliferation
D0010460biological_processpositive regulation of heart rate
D0016020cellular_componentmembrane
D0016925biological_processprotein sumoylation
D0019722biological_processcalcium-mediated signaling
D0030502biological_processnegative regulation of bone mineralization
D0034220biological_processmonoatomic ion transmembrane transport
D0034706cellular_componentsodium channel complex
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0042391biological_processregulation of membrane potential
D0043025cellular_componentneuronal cell body
D0045600biological_processpositive regulation of fat cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045907biological_processpositive regulation of vasoconstriction
D0046872molecular_functionmetal ion binding
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071318biological_processcellular response to ATP
D0086045biological_processmembrane depolarization during AV node cell action potential
D0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
D0086048biological_processmembrane depolarization during bundle of His cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0098662biological_processinorganic cation transmembrane transport
D0098719biological_processsodium ion import across plasma membrane
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
D1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
D1904179biological_processpositive regulation of adipose tissue development
D1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3996
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29211714
ChainResidueDetails
BMET1-ALA778
CGLY832-THR859
CTHR907-VAL926
CALA1037-ASP1213
DMET1-ALA778
DGLY832-THR859
DTHR907-VAL926
DALA1037-ASP1213
BGLY832-THR859
BTHR907-VAL926
BALA1037-ASP1213
AMET1-ALA778
AGLY832-THR859
ATHR907-VAL926
AALA1037-ASP1213
CMET1-ALA778

site_idSWS_FT_FI2
Number of Residues492
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:29211714
ChainResidueDetails
BPHE779-VAL799
ALEU883-PHE906
APHE927-ILE947
AVAL1016-ILE1036
CPHE779-VAL799
CLEU811-GLY831
CTRP860-THR880
CLEU883-PHE906
CPHE927-ILE947
CVAL1016-ILE1036
DPHE779-VAL799
BLEU811-GLY831
DLEU811-GLY831
DTRP860-THR880
DLEU883-PHE906
DPHE927-ILE947
DVAL1016-ILE1036
BTRP860-THR880
BLEU883-PHE906
BPHE927-ILE947
BVAL1016-ILE1036
APHE779-VAL799
ALEU811-GLY831
ATRP860-THR880

site_idSWS_FT_FI3
Number of Residues224
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29211714
ChainResidueDetails
BASP800-GLU810
CPRO881-GLY882
CLEU948-LEU959
CVAL981-LEU1015
DASP800-GLU810
DPRO881-GLY882
DLEU948-LEU959
DVAL981-LEU1015
BPRO881-GLY882
BLEU948-LEU959
BVAL981-LEU1015
AASP800-GLU810
APRO881-GLY882
ALEU948-LEU959
AVAL981-LEU1015
CASP800-GLU810

site_idSWS_FT_FI4
Number of Residues80
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:29211714
ChainResidueDetails
BARG960-ASP980
AARG960-ASP980
CARG960-ASP980
DARG960-ASP980

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:29211714, ECO:0007744|PDB:6BCO, ECO:0007744|PDB:6BCQ
ChainResidueDetails
BARG172
AARG172
CARG172
DARG172

site_idSWS_FT_FI6
Number of Residues40
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q8TD43
ChainResidueDetails
BARG215
BASP864
AARG215
ALEU226
AASP271
AALA393
AASP396
AGLU397
AGLU824
AGLN827
AASN861
BLEU226
AASP864
CARG215
CLEU226
CASP271
CALA393
CASP396
CGLU397
CGLU824
CGLN827
CASN861
BASP271
CASP864
DARG215
DLEU226
DASP271
DALA393
DASP396
DGLU397
DGLU824
DGLN827
DASN861
BALA393
DASP864
BASP396
BGLU397
BGLU824
BGLN827
BASN861

site_idSWS_FT_FI7
Number of Residues8
DetailsBINDING: in other chain => ECO:0000269|PubMed:29211714, ECO:0007744|PDB:6BCO, ECO:0007744|PDB:6BCQ
ChainResidueDetails
BARG422
BGLY449
AARG422
AGLY449
CARG422
CGLY449
DARG422
DGLY449

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9ESQ5
ChainResidueDetails
BSER527
ASER527
CSER527
DSER527

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER538
ASER538
CSER538
DSER538

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q8TD43
ChainResidueDetails
BSER1144
BSER1151
ASER1144
ASER1151
CSER1144
CSER1151
DSER1144
DSER1151

225946

PDB entries from 2024-10-09

PDB statisticsPDBj update infoContact PDBjnumon