Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6BCJ

cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002407biological_processdendritic cell chemotaxis
A0002724biological_processregulation of T cell cytokine production
A0005216molecular_functionmonoatomic ion channel activity
A0005227molecular_functioncalcium-activated cation channel activity
A0005244molecular_functionvoltage-gated monoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007616biological_processlong-term memory
A0008284biological_processpositive regulation of cell population proliferation
A0010460biological_processpositive regulation of heart rate
A0016020cellular_componentmembrane
A0016925biological_processprotein sumoylation
A0019722biological_processcalcium-mediated signaling
A0030502biological_processnegative regulation of bone mineralization
A0034220biological_processmonoatomic ion transmembrane transport
A0034706cellular_componentsodium channel complex
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042391biological_processregulation of membrane potential
A0043025cellular_componentneuronal cell body
A0045600biological_processpositive regulation of fat cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071318biological_processcellular response to ATP
A0086045biological_processmembrane depolarization during AV node cell action potential
A0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
A0086048biological_processmembrane depolarization during bundle of His cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0098662biological_processinorganic cation transmembrane transport
A0098719biological_processsodium ion import across plasma membrane
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
A0099604molecular_functionligand-gated calcium channel activity
A1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
A1904179biological_processpositive regulation of adipose tissue development
A1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
B0002250biological_processadaptive immune response
B0002407biological_processdendritic cell chemotaxis
B0002724biological_processregulation of T cell cytokine production
B0005216molecular_functionmonoatomic ion channel activity
B0005227molecular_functioncalcium-activated cation channel activity
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007616biological_processlong-term memory
B0008284biological_processpositive regulation of cell population proliferation
B0010460biological_processpositive regulation of heart rate
B0016020cellular_componentmembrane
B0016925biological_processprotein sumoylation
B0019722biological_processcalcium-mediated signaling
B0030502biological_processnegative regulation of bone mineralization
B0034220biological_processmonoatomic ion transmembrane transport
B0034706cellular_componentsodium channel complex
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042391biological_processregulation of membrane potential
B0043025cellular_componentneuronal cell body
B0045600biological_processpositive regulation of fat cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071318biological_processcellular response to ATP
B0086045biological_processmembrane depolarization during AV node cell action potential
B0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
B0086048biological_processmembrane depolarization during bundle of His cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0098662biological_processinorganic cation transmembrane transport
B0098719biological_processsodium ion import across plasma membrane
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
B0099604molecular_functionligand-gated calcium channel activity
B1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
B1904179biological_processpositive regulation of adipose tissue development
B1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
C0002250biological_processadaptive immune response
C0002407biological_processdendritic cell chemotaxis
C0002724biological_processregulation of T cell cytokine production
C0005216molecular_functionmonoatomic ion channel activity
C0005227molecular_functioncalcium-activated cation channel activity
C0005244molecular_functionvoltage-gated monoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005654cellular_componentnucleoplasm
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007616biological_processlong-term memory
C0008284biological_processpositive regulation of cell population proliferation
C0010460biological_processpositive regulation of heart rate
C0016020cellular_componentmembrane
C0016925biological_processprotein sumoylation
C0019722biological_processcalcium-mediated signaling
C0030502biological_processnegative regulation of bone mineralization
C0034220biological_processmonoatomic ion transmembrane transport
C0034706cellular_componentsodium channel complex
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0042391biological_processregulation of membrane potential
C0043025cellular_componentneuronal cell body
C0045600biological_processpositive regulation of fat cell differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045907biological_processpositive regulation of vasoconstriction
C0046872molecular_functionmetal ion binding
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071318biological_processcellular response to ATP
C0086045biological_processmembrane depolarization during AV node cell action potential
C0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
C0086048biological_processmembrane depolarization during bundle of His cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0098662biological_processinorganic cation transmembrane transport
C0098719biological_processsodium ion import across plasma membrane
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
C0099604molecular_functionligand-gated calcium channel activity
C1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
C1904179biological_processpositive regulation of adipose tissue development
C1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
D0002250biological_processadaptive immune response
D0002407biological_processdendritic cell chemotaxis
D0002724biological_processregulation of T cell cytokine production
D0005216molecular_functionmonoatomic ion channel activity
D0005227molecular_functioncalcium-activated cation channel activity
D0005244molecular_functionvoltage-gated monoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005654cellular_componentnucleoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007616biological_processlong-term memory
D0008284biological_processpositive regulation of cell population proliferation
D0010460biological_processpositive regulation of heart rate
D0016020cellular_componentmembrane
D0016925biological_processprotein sumoylation
D0019722biological_processcalcium-mediated signaling
D0030502biological_processnegative regulation of bone mineralization
D0034220biological_processmonoatomic ion transmembrane transport
D0034706cellular_componentsodium channel complex
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0042391biological_processregulation of membrane potential
D0043025cellular_componentneuronal cell body
D0045600biological_processpositive regulation of fat cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045907biological_processpositive regulation of vasoconstriction
D0046872molecular_functionmetal ion binding
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071318biological_processcellular response to ATP
D0086045biological_processmembrane depolarization during AV node cell action potential
D0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
D0086048biological_processmembrane depolarization during bundle of His cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0098662biological_processinorganic cation transmembrane transport
D0098719biological_processsodium ion import across plasma membrane
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
D0099604molecular_functionligand-gated calcium channel activity
D1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
D1904179biological_processpositive regulation of adipose tissue development
D1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue NA A 1301
ChainResidue
ANA1302

site_idAC2
Number of Residues1
Detailsbinding site for residue NA A 1302
ChainResidue
ANA1301

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3996
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29211714
ChainResidueDetails
BMET1-ALA778
CGLY832-THR859
CTHR907-VAL926
CALA1037-ASP1213
DMET1-ALA778
DGLY832-THR859
DTHR907-VAL926
DALA1037-ASP1213
BGLY832-THR859
BTHR907-VAL926
BALA1037-ASP1213
AMET1-ALA778
AGLY832-THR859
ATHR907-VAL926
AALA1037-ASP1213
CMET1-ALA778

site_idSWS_FT_FI2
Number of Residues492
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:29211714
ChainResidueDetails
BPHE779-VAL799
ALEU883-PHE906
APHE927-ILE947
AVAL1016-ILE1036
CPHE779-VAL799
CLEU811-GLY831
CTRP860-THR880
CLEU883-PHE906
CPHE927-ILE947
CVAL1016-ILE1036
DPHE779-VAL799
BLEU811-GLY831
DLEU811-GLY831
DTRP860-THR880
DLEU883-PHE906
DPHE927-ILE947
DVAL1016-ILE1036
BTRP860-THR880
BLEU883-PHE906
BPHE927-ILE947
BVAL1016-ILE1036
APHE779-VAL799
ALEU811-GLY831
ATRP860-THR880

site_idSWS_FT_FI3
Number of Residues224
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29211714
ChainResidueDetails
BASP800-GLU810
CPRO881-GLY882
CLEU948-LEU959
CVAL981-LEU1015
DASP800-GLU810
DPRO881-GLY882
DLEU948-LEU959
DVAL981-LEU1015
BPRO881-GLY882
BLEU948-LEU959
BVAL981-LEU1015
AASP800-GLU810
APRO881-GLY882
ALEU948-LEU959
AVAL981-LEU1015
CASP800-GLU810

site_idSWS_FT_FI4
Number of Residues80
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:29211714
ChainResidueDetails
BARG960-ASP980
AARG960-ASP980
CARG960-ASP980
DARG960-ASP980

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:29211714, ECO:0007744|PDB:6BCO, ECO:0007744|PDB:6BCQ
ChainResidueDetails
BARG172
AARG172
CARG172
DARG172

site_idSWS_FT_FI6
Number of Residues8
DetailsBINDING: in other chain => ECO:0000269|PubMed:29211714, ECO:0007744|PDB:6BCO, ECO:0007744|PDB:6BCQ
ChainResidueDetails
BARG422
BGLY449
AARG422
AGLY449
CARG422
CGLY449
DARG422
DGLY449

site_idSWS_FT_FI7
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q8TD43
ChainResidueDetails
BGLU824
CGLN827
CASN861
CASP864
DGLU824
DGLN827
DASN861
DASP864
BGLN827
BASN861
BASP864
AGLU824
AGLN827
AASN861
AASP864
CGLU824

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9ESQ5
ChainResidueDetails
BSER527
ASER527
CSER527
DSER527

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER538
ASER538
CSER538
DSER538

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q8TD43
ChainResidueDetails
BSER1144
BSER1151
ASER1144
ASER1151
CSER1144
CSER1151
DSER1144
DSER1151

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon