6BC3
Cryo X-ray structure of sisomicin bound AAC-VIa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue COA A 301 |
| Chain | Residue |
| A | ARG28 |
| A | ALA118 |
| A | PHE122 |
| A | ALA180 |
| A | ASP183 |
| A | ALA184 |
| A | THR186 |
| A | SIS302 |
| A | HOH411 |
| A | HOH416 |
| A | HOH450 |
| A | HIS44 |
| A | HOH472 |
| A | HOH491 |
| A | HOH505 |
| A | VAL45 |
| A | SER46 |
| A | LEU47 |
| A | ARG48 |
| A | PHE77 |
| A | PHE116 |
| A | GLY117 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue SIS A 302 |
| Chain | Residue |
| A | SER79 |
| A | TYR85 |
| A | GLU86 |
| A | TYR113 |
| A | PHE116 |
| A | ASP136 |
| A | TYR159 |
| A | ASP183 |
| A | HIS189 |
| A | SER225 |
| A | ASN226 |
| A | COA301 |
| A | HOH452 |
| A | HOH453 |
| A | HOH529 |
