6BC3

Cryo X-ray structure of sisomicin bound AAC-VIa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008080	molecular_function	N-acetyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046353	molecular_function	aminoglycoside 3-N-acetyltransferase activity
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue COA A 301

Chain	Residue
A	ARG28
A	ALA118
A	PHE122
A	ALA180
A	ASP183
A	ALA184
A	THR186
A	SIS302
A	HOH411
A	HOH416
A	HOH450
A	HIS44
A	HOH472
A	HOH491
A	HOH505
A	VAL45
A	SER46
A	LEU47
A	ARG48
A	PHE77
A	PHE116
A	GLY117

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site_id	AC2
Number of Residues	15
Details	binding site for residue SIS A 302

Chain	Residue
A	SER79
A	TYR85
A	GLU86
A	TYR113
A	PHE116
A	ASP136
A	TYR159
A	ASP183
A	HIS189
A	SER225
A	ASN226
A	COA301
A	HOH452
A	HOH453
A	HOH529

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